Abstract: A method of forming a part from sheet metal alloy is provided, for example, forming a part from aluminium alloy. The method comprises heating (A) the sheet metal alloy to a temperature at which solution heat treatment of the alloy occurs and so as to achieve solution heat treatment. The sheet is cooled (B) at at least the critical cooling rate for the alloy and then placed between dies to form (C) it into or towards the part.

Abstract: A silicone modified lubricant includes a Group I, II, III, IV or V base oil in combination with a minor amount of a silicone oil. Further, the lubricant includes a dispersant such as a dispersant olefin copolymer which maintains the silicone oil dispersed in the base oil. The silicone oil reduces the surface tension of the lubricant thereby reducing power loss. Preferably the lubricant formation has a surface tension less than 28 mN/m, making it particularly suitable for dip lubrication systems.

Abstract: The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium (III) 2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N?-amido-methyl]-1,4,7,10- =tetra-azacyclododec-1-yl}-acetic acid), characterised in that the liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phospocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.

Abstract: The present disclosure relates generally to the assessment and treatment of vessels, including for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). For example, some embodiments of the present disclosure are suited for identifying the available intervention technique(s) suitable to achieve a desired outcome selected or input by a user. For example, in some implementations a method comprises receiving pressure measurements obtained by one or more intravascular pressure-sensing instruments positioned within a vessel of a patient; receiving an input from a user regarding a desired pressure value for the vessel of the patient; identifying an available treatment option based on the received pressure measurements and the desired pressure value; and outputting, to a display device, a screen display including a visual representation of the available treatment option. Related devices and systems are also described.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent. In some embodiments, the devices, systems, and methods of the present disclosure are configured to assess a vessel by automatically correcting for drift in the equipment utilized to obtain measurements related to the vessel.

Abstract: A compound for an infrared light sensing device may be represented by a particular chemical formula and may be included in an infrared light sensing device. An image sensor may include the infrared light sensing device, and an electronic device may include the image sensor.

Abstract: An ear examination tool comprises a handle and a speculum mount coupled to the handle. The speculum mount is configured for retaining a disposable speculum. An spacing element is coupled to the handle and extends from the handle. A smartphone mount is coupled to the spacing element, and the spacing element is configured to maintain an optical separation distance between the speculum mount and the smartphone mount. The tool enables a clear view of the ear canal while allowing access by, and manipulation of, a microsuction tool being inserted into the ear canal. The extensive optical and data processing functionality of a “smartphone” can be integrated at low cost into an ear examination tool to provide a substantially improved piece of equipment for assisting in ear examination and microsuction of the ear.

Abstract: A method of subsurface exploration includes generating a representation of a portional volume of the Earth from a seismic measurement of a physical parameter.

Abstract: A power compensator for compensating voltage at a location along a power transmission line, the compensator having a controller for controlling a voltage generated across the compensator, wherein the voltage is controlled to maintain a power transmission line voltage at a value dependent on the power transmission line location.

Abstract: A method of mapping a tissue characteristic in a tissue sample comprises gathering infrared absorption data from the sample at selected wavelengths, and determining, from the infrared absorption data, a first measure of the amount of power or energy absorbed attributable to an amide moiety and a second measure of the amount of power or energy absorbed attributable to a phosphate moiety. A ratio of the first measure and the second measure is used to establish a histological index. The histological index may be used to indicate a malignancy grade of tumour in the tissue.

Abstract: There is provided a regenerative fuel cell capable of operating in a power delivery mode in and in an energy storage mode. The cell may comprise a reversible hydrogen gas anode, in an anode compartment, a reversible cathode in a cathode compartment, and a membrane separating the anode compartment from the cathode compartment, which membrane is capable of selectively passing protons. an additive may be provided in the cathode compartment.

Abstract: The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.

Abstract: A method of use of an isolated polypeptide conjugated with a radionuclide, wherein the isolated polypeptide binds specifically to HER2, or a variant thereof is described. The method is for monitoring the response to HSP90 inhibition and comprises the use of the isolated polypeptide conjugated with 18F. The application also describes the use of an isolated polypeptide conjugated with 18F, wherein the isolated polypeptide binds specifically to HER2 or variants thereof, as an imaging agent to monitor uptake thereof to measure HSP90 inhibition.

Abstract: A prosthetic glenoid component (10) comprising a concave external bearing surface (12), a glenoid-contacting surface (14) opposite to the bearing surface, and a plurality of fixation elements (16) protruding from said glenoid-contacting surface (14) oppositely to said bearing surface (12) for location into a peripheral portion (104b) of a glenoid cavity (104) to secure the component to the scapula (102), wherein a central portion (15) of the glenoid-contacting surface (14) is free of fixation elements so as to preserve the integrity of the glenoid vault.

Abstract: The present invention related to identification of therapeutic agents of the treatment, diagnosis, and prevention of pulmonary hypertension.

Abstract: There is provided a light source arranged to output light at a first wavelength. The light source comprises a luminescent concentrator having a slab-shaped geometry. The luminescent concentrator comprises: an input port arranged to receive light and define a first area; an output port arranged to transmit light and define a second area which is smaller than the first area; and surfaces arranged to direct light inside the luminescent concentrator to the output port. The luminescent concentrator further comprises lumophores arranged to receive light at a second wavelength and emit light at the first wavelength; and a pump light supply coupled to the input port and arranged to illuminate the input port with light at the second wavelength.

Abstract: A fuel cell assembly is disclosed comprising a fuel cell electrode component and a reactant gas flow component ink bonded thereto. In one aspect direct bonding of a gas diffusion layer with a flow field is achieved allowing a simplified structural configuration. In another aspect improved component printing techniques reduce corrosion effects. In a further aspect flow fields are described providing reactant channels extending in both the horizontal and vertical directions, i.e. providing three dimensional flow. In a further aspect an improved wicking material allows wicking away and reactant humidification. In a further aspect improved mechanical fastenings and connectors are provided. In a further aspect improved humidification approaches are described. Further improved aspects are additionally disclosed.

Abstract: An implantable device for deployment inside a human or animal body, the device comprising at least one sensing component arranged to respond to an electrical signal having a known frequency band and at least one antenna comprising at least one antenna pole connected to the at least one sensing component, the antenna pole comprising at least one helical coil and a connecting stem.

Abstract: An implantable intravascular device for deployment inside a human or animal, the apparatus comprising a body of crystalline material and a membrane of crystalline material fixed to the body by a hermetic bond an assembly of components carried on said crystalline material and arranged for responding to electrical signals wherein the body and the membrane at least partially encapsulate the assembly.

Abstract: An implantable intravascular pressure sensor comprising a first transducer arranged to provide a pressure dependent signal in response to alternating electrical signals of a first frequency band, a second transducer arranged to provide a reference signal in response to alternating electrical signals of a second frequency band different from the first frequency band and an antenna coupling for sending and receiving said signals.