Abstract: The invention provides a process for the synthesis of a polycarbonate, the process comprising the step of reacting carbon dioxide with at least one epoxide in the presence of a catalyst of formula (I) and a chain transfer agent. The invention also provides a polymerization system for the copolymerization of carbon dioxide and at least one epoxide comprising a catalyst of formula (I) and a chain transfer agent, polycarbonates produced by the inventive process, a block copolymer comprising a polycarbonate produced by the inventive process, and a method of producing the block copolymer. The invention also relates to novel catalysts of formula (III).

Abstract: Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.

Abstract: A device able to generate electrical power through relative rotational motion of first (370, 380) and second (200, 230) principal components around an axis of rotation (220); wherein: the first and second principal components comprise an arrangement of piezoelectric elements (380) and permanent magnets (230, 370) such that the interaction between these magnets and piezoelectric elements, in use, makes it possible to generate electricity; and wherein: the second principal component (200, 230) comprises a centre of mass offset from the axis of relative rotation (220) such that the response of the second principal component (200, 230) to either gravitational or inertial forces is a relative rotation of the second principal component (200, 230) in relation to the first principal component (370, 380); the first principal component (370, 380) being fixedly attached to the moving host structure (100).

Abstract: Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.

Abstract: The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerising carbon dioxide and an epoxide.

Abstract: Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the ?-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake.

Abstract: The present invention provides a regenerative fuel cell comprising a reversible hydrogen gas anode, in an anode compartment and a reversible cathode in a cathode compartment, wherein the redox reaction at the cathode is selected from formula (i), formula (ii) and formula (iii).

Abstract: A flow control device for a turbocharger (100) includes a flow restrictor (102) with a variable position for variably restricting flow in a turbocharger inlet. A controller (312) controls the position of the flow restrictor based on sensed pressure (300) in the turbocharger inlet (301).

Abstract: A method is provided of forming a part from sheet steel. The method comprises the steps of (a) heating the sheet to a temperature at which austenitisation occurs; and (b) forming the sheet between dies into the part, father cooling the formed sheet. There is an additional step between (a) and (b) of applying cooling means to the sheet.

Abstract: Peptide analogs of peptide YY (PYY), compositions comprising them, and methods of using those analogs or compositions for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as diabetes and obesity, and for reduction in appetite, reduction in food intake or reduction of calorie intake in a subject, are provided herein.

Abstract: Improved integrally skinned asymmetric membranes for organic solvent nanofiltration, and their methods of preparation and use are disclosed. Membranes are formed from polyimides by phase inversion and are then crosslinked by addition of amine crosslinking agents that react with the imide groups of the polyimide, creating amide bonds. These stabilize the membranes and allow solvent nanofiltration to be maintained even in the solvents from which the membranes were formed by phase inversion.

Abstract: A method of controlling operation of a froth floatation cell for separating substances comprises introducing gas into liquid in the cell, creating a froth controlling gas flow rate into the cell in order to maximize gas recovery for the cell.

Abstract: A method and system for rendering a captured image of a scene is disclosed which provide see-through vision through the rendered image, for example of an augmented reality object rendered behind the scene, by assigning pixel transparency values in dependence upon captured image pixels. The method and system preserve some structure of the scene in the rendered image without requiring a model of the scene.

Abstract: A method for depositing one or more organic layers onto a substrate, which includes: transferring the one or more layers from a depositing surface of a stamp to the substrate by bringing the layer coated depositing surface of the stamp into contact with the substrate, and the use of either or both of the steps of: (i) contacting the polymer with a plasticizer; and (ii) heating the substrate and/or stamp, in order to create favorable conditions for conformal contact and uniform layer transfer.

Abstract: A method for aiding in selecting or adjusting a dose of TSPO imaging or therapeutic agent for use with a subject, the method comprising the step of determining the subject's genotype for TSPO rs6971. A TSPO imaging or therapeutic agent for use in TSPO imaging or therapy in a subject, wherein the subject is a subject whose genotype at TSPO polymorphism position rs6971 is determined. The subject's genotype for TSPO may be taken into account when assessing the results of the TSPO imaging, for example normalising the subject's determined measure of binding of the TSPO agent to take account of the subject's determined genotype. The subject's genotype for TSPO may be taken into account when choosing the TSPO agent and/or the dose of TSPO agent. The subject may be a subject who has been determined to have genotype CC or CT at TSPO polymorphism position rs6971, for example when using a TSPO agent that binds with higher affinity to Aia147TSPO than to Thr147TSPO.

Abstract: A method of manufacturing a multi-material gear is disclosed. The method comprises the steps of (a) heating a first pre-form element of a first material to a temperature at which the first material can be formed; (b) heating a second pre-form element of a second material to a temperature at which the second material can be formed; and (c) forming the first and second pre-form elements in a die at least towards the shape of the gear, thereby providing bonding between the elements.

Abstract: An apparatus for obtaining EEG data includes a signal processing component for receiving EEG signals from each of a plurality of electrodes and a data output component. The signal processing component is arranged to convert respective EEG signals in real time to a reduced data set and provide the reduced data set to the data output component.

Abstract: Among the fewer than 10 proteins primarily secreted by the species Lactobacillus plantarum, there is one of 30 kDa that contains an internal fragment without cleavage sites for the most important intestinal proteases and characterized by having a serine and threonine content of at least 50%. The genetic information encoded in this fragment, designated ST peptide, has been used for producing and purifying said peptide, thus making it possible to conduct various tests in vitro. To summarize, the ST peptide is considered to promote the process of immunologic ignorance of our gastrointestinal immune system toward the commensal bacteria of our gastrointestinal tract, thus favoring the mechanisms of oral tolerance. Therefore the ST peptide could be used in immunotherapy, especially in the context of certain autoimmune diseases and certain inflammatory diseases.

Abstract: A method of generating an image data set, describing an object, as the object moves in a scanning space, comprises: a) performing a plurality of scans of the scanning space each scan being arranged to generate a set of samples, each sample including a sample value of at least one parameter associated with a respective point in the scanning space, the plurality of scans generating sample sets relating to a plurality of different parameters; b) determining a mapping for each of the samples from the scanning space into an object space which is fixed relative to the object; and c) determining object space values for each of the parameters at each of a plurality of points in the object space.

Abstract: An apparatus and method for ultrasonic non-destructive testing provides an elongate strip of ultrasound transmissive material coupled at a proximal end to an object under test. The elongate strip has a transverse cross-section with a width and thickness giving an aspect ratio greater than unity and matched to the ultrasonic transducer such that excitation induces a substantially non-dispersive ultrasonic signal to propagate along the elongate strip to the proximal end and to enter the object under test. These non-dispersive pulses are particularly suited for time-of-flight measurements, thickness measurements, crack measurements and the like. The elongate strip helps to separate the transducer from a potentially hostile environment associated with the object under test. The elongate strip also has a large area of contact with the object under test allowing efficient transmission of energy into the object under test.