Abstract: Methods for producing improved anti-human thymocyte immunoglobulins from specific-pathogen-free animals are provided, without the need for an adsorption step on human tissues and the consequent drawbacks of such a step.
Abstract: Mean survival times of a functional transplant of solid organs in a patient are increased by administering to the patient an initial dosing of a therapeutically effective amounts of a monoclonal antibody directed against the human LFA-1 molecule in the two hours after grafting and then administering daily dosing during a period of approximately nine days.
Type:
Grant
Filed:
October 30, 1995
Date of Patent:
April 10, 2001
Assignee:
Imtix-Sangstat
Inventors:
Gilles Alberici, Pierre Caudrelier, Brigitte Le Mauff, Maryvonne Hourmant, Jean-Paul Soulillou