Patents Assigned to Incyte Genomics, Inc.
-
Publication number: 20030166859Abstract: The present invention provides a human growth factor receptor binding protein (GRBP) and polynucleotides which encode GRBP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing GRBP and for treating disorders associated with expression of GRBP.Type: ApplicationFiled: June 28, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Anthony P. Diegidio
-
Publication number: 20030165905Abstract: Methods are provide for modifying a solid support, such as a glass slide, by silylating with an agent having the formula H2N—(CH2)n—SiX3 where n is between 1 and 10, and X is independently chosen from OMe, OEt, Cl, Br, or I, then activating with a crosslinking reagent, followed by reacting with an amine-containing polymer. The support can optionally be reacted with a crosslinking reagent again. The support thus modified may be used to make arrays and microarrays where a plurality of targets are stably associated with the support and arranged in a defined manner.Type: ApplicationFiled: July 1, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Lyle J. Arnold, Samuel P. Sawan, Paul H. Lee
-
Publication number: 20030166136Abstract: The present invention provides a new human C-type lectin (CTL-1)) and polynucleotides which encode CTL-1. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of CTL-1.Type: ApplicationFiled: June 24, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Purvi Shah
-
Publication number: 20030166231Abstract: The present invention provides a human RNA binding protein (HRNABP) and polynucleotides which identify and encode HRNABP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRNABP and a method for producing HRNABP. The invention also provides for antagonists or antibodies specifically binding HRNABP, and their use, in the prevention and treatment of diseases associated with expression of HRNABP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRNABP for the treatment of diseases associated with the expression of HRNABP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRNABP.Type: ApplicationFiled: May 31, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Surya K. Goli
-
Publication number: 20030166246Abstract: The invention provides human aspartic proteases (NHAP) and polynucleotides which identify and encode NHAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NHAP.Type: ApplicationFiled: June 25, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Hong Xu, Sandra A. Bruno, Laura A. Elsenboss, Michael Fogliano, Victoria L. Cohan, Olga Bandman
-
Publication number: 20030166216Abstract: The invention provides a human checkpoint kinase (hChk1) and polynucleotides which identify and encode hChk1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of hChk1.Type: ApplicationFiled: May 6, 2002Publication date: September 4, 2003Applicant: Incyte Genomics, Inc.Inventors: Stephen Green, Andrea Georgina King, Olga Bandman, Susan G. Stuart
-
Patent number: 6613529Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids, undergoing a reaction. The apparatus comprises a means for creating a bubble within the film of fluid, and moving the bubble in the fluid, thereby mixing the fluid.Type: GrantFiled: July 15, 2002Date of Patent: September 2, 2003Assignee: Incyte Genomics Inc.Inventors: Tod Bedilion, Loren Titsworth, Erik Bjeldanes, Douglas Gilliland, Lyle Arnold
-
Patent number: 6611828Abstract: Disclosed are methods, media and systems for graphically displaying computer-based biomolecular sequence information. Generally, biomolecular sequence information may be graphically depicted in a variety of different forms in accordance with the present invention. The sequence information may be composed of nucleotide or amino acid sequence information or both. The graphical depictions may be in several different formats providing different information relating to the sequences, and may be displayed in one or more screens of a computer user interface.Type: GrantFiled: February 2, 2001Date of Patent: August 26, 2003Assignee: Incyte Genomics, Inc.Inventors: Alex George Koleszar, Jeanette Schmidt, Megan E. Grether
-
Publication number: 20030152989Abstract: The present invention provides a novel human integral membrane (IMP-2) and polynucleotides which identify and encode IMP-2. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding IMP-2 and a method for producing IMP-2. The invention also provides for agonists, antibodies, or antagonists specifically binding IMP-2, and their use, in the prevention and treatment of diseases associated with expression of IMP-2. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding IMP-2 for the treatment of diseases associated with the expression of IMP-2. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding IMP-2.Type: ApplicationFiled: February 11, 2003Publication date: August 14, 2003Applicant: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Surya K. Goli
-
Publication number: 20030148363Abstract: The invention provides human hydrolase-like molecules (HHLM) and polynucleotides which identify and encode HHLM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HHLM.Type: ApplicationFiled: February 5, 2003Publication date: August 7, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Preeti Lal, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Purvi Shah
-
Publication number: 20030143617Abstract: The present invention provides two ATP synthase subunits (designated individually as Asy-1 and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.Type: ApplicationFiled: January 21, 2003Publication date: July 31, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Jennifer L. Hillman, Surya K. Goli
-
Publication number: 20030143686Abstract: The invention provides human transferases (TRNFR) and polynucleotides which identify and encode TRNFR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRNFR.Type: ApplicationFiled: November 4, 2002Publication date: July 31, 2003Applicant: Incyte Genomics, Inc.Inventors: Preeti G. Lal, Y. Tom Tang, Henry Yue, Neil Burford, Ameena R. Gandhi, Bridget A. Warren, Monique G. Yao, Catherine M. Tribouley, Mariah R. Baughn, Ernestine A. Lee, April J.A. Hafalia, Yan Lu, Jennifer A. Griffin, Madhusudan M. Sanjanwala, Li Ding
-
Publication number: 20030143589Abstract: The invention provides human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.Type: ApplicationFiled: October 18, 2002Publication date: July 31, 2003Applicant: Incyte Genomics, Inc.Inventors: Mariah R. Baughn, Christopher M. Bruns, Debopriya Das, Li Ding, Vicki S. Elliott, Ameena R. Gandhi, April J.A. Hafalia, Liam Kearney, Farrah A. Khan, Preeti G. Lal, Ernestine A. Lee, Dyung Aina M. Lu, Yan Lu, Danniel B. Nguyen, Chandra S. Arvizu, Jayalaxmi Ramkumar, Huijun Z. Ring, Madhusudan M. Sanjanwala, Y. Tom Tang, Kavitha Thangavelu, Michael B. Thornton, Catherine M. Tribouley, Narinder K. Chawla, Yuming Xu, Junming Yang, Monique G. Yao, Henry Yue
-
Publication number: 20030143588Abstract: The invention provides human phosphodiesterases (HPDE) and polynucleotides which identify and encode HPDE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of HPDE.Type: ApplicationFiled: October 18, 2002Publication date: July 31, 2003Applicant: Incyte Genomics, Inc.Inventors: Michael B. Thornton, Li Ding, Chandra S. Arvizu, Monique G. Yao, Catherine M. Tribouley, Preeti G. Lal, April J. A. Hafalia, Mariah R. Baughn, Jayalaxmi Ramkumar, Yan Lu, Narinder K. Chawla
-
Publication number: 20030143622Abstract: The invention provides human RNA binding proteins (RNABP) and polynucleotides which identify and encode RNABP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RNABP.Type: ApplicationFiled: February 5, 2003Publication date: July 31, 2003Applicant: Incyte Genomics, Inc.Inventors: Olga Bandman, Y. Tom Tang, Neil C. Corley, Karl J. Guegler, Dyung Aina M. Lu, Mariah R. Baughn
-
Publication number: 20030143691Abstract: The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HTES.Type: ApplicationFiled: February 3, 2003Publication date: July 31, 2003Applicant: Incyte Genomics, Inc.Inventors: Preeti Lal, Karl J. Guegler, Neil C. Corley
-
Publication number: 20030138835Abstract: The invention provides a mammalian cDNA which encodes a mammalian MTSP. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly breast cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.Type: ApplicationFiled: January 21, 2003Publication date: July 24, 2003Applicant: Incyte Genomics, Inc.Inventors: Susan G. Stuart, Henry Yue, Mariah R. Baughn, David G. Streeter
-
Publication number: 20030139578Abstract: The invention provides a antibody that specifically binds human PDE8s and is used to diagnose, stage and treat prostate cancer.Type: ApplicationFiled: October 15, 2002Publication date: July 24, 2003Applicant: Incyte Genomics, Inc.Inventors: Janice K. Au-Young, Benjamin G. Cocks, Roger T. Coleman, Jeffrey J. Seilhamer, Douglas A. Fisher
-
Publication number: 20030135027Abstract: The invention provides a mammalian imidazoline receptor, its encoding cDNA and an antibody that specifically binds the protein; each of which is useful to diagnose, stage, treat or monitor the progression or treatment of cancer, hypertension, immune disorder or reproductive disorder.Type: ApplicationFiled: October 29, 2002Publication date: July 17, 2003Applicant: Incyte Genomics, Inc.Inventors: Preeti G. Lal, Y. Tom Tang, Mariah R. Baughn, Matthew R. Kaser
-
Publication number: 20030129176Abstract: The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in cardiovascular diseases. The combination and compositions can be used entirely or in part to diagnose, to stage, to treat, or to monitor the progression or treatment of disorders associated with atherosclerosis.Type: ApplicationFiled: August 14, 2002Publication date: July 10, 2003Applicant: Incyte Genomics, Inc.Inventors: Karen Anne Jones, Wayne Volkmuth, Michael G. Walker, Lynn E. Murry