Abstract: The invention relates to molecules having Formula (100): wherein ————— represents a bond present or absent; Ar is a substituted or unsubstituted benzene or pyridine ring; V is a C or N atom, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-4-thiazolidinedione, isoxazolidinedione, 2,4-imidazolidinedione, [1,2,4]-oxadiazolidine-3,5-dione or 2-thioxo-4-imidazolidinedione residue; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
March 8, 2002
Date of Patent:
September 4, 2007
Assignees:
Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease
Type:
Grant
Filed:
August 24, 2005
Date of Patent:
June 5, 2007
Assignees:
Incyte San Diego, Inc., Ortho McNeil Pharmaceutical Inc.
Inventors:
Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul, David P. M. Pleynet, Lyle W. Spruce
Abstract: The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis.
Type:
Grant
Filed:
March 6, 2003
Date of Patent:
March 27, 2007
Assignees:
Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
Inventors:
Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul Giachino, Karine Jakubowicz-Jaillardon, Jianhua Guo, Richard M. Fine, Lyle W. Spruce, James W. Zapf
Abstract: The invention relates to certain heterocyclic compounds useful for the treatment of cancer and other diseases, having the Formula (I): wherein: (a) m is an integer 0 or 1; (b) R12 is an alkyl, a substituted alkyl, a cycloalkyl, a substituted cycloalkyl, a heterocyclic, a substituted heterocyclic, a heteroaryl, a substituted heteroaryl, an aryl or a substituted aryl residue; (c) Ar3 is an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (d) Ar4 is an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl residue; (e) R5 is hydrogen, hydroxy, alkyl or substituted alkyl; (f) ----- represents a bond present or absent; and (g) W, X, Y and Z are independently or together —C(O)—, C(S), S, O, or NH; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
March 7, 2002
Date of Patent:
December 26, 2006
Assignee:
Incyte San Diego
Inventors:
Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul, David P.M. Pleynet, Lyle W. Spruce, Torsten R. Wiemann, Jason B. Ibarra
Abstract: The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.
Type:
Grant
Filed:
March 6, 2003
Date of Patent:
September 5, 2006
Assignees:
Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
Inventors:
Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul Giachino, Karine Jakubowicz-Jaillardon, Jianhua Guo, Mohamed Boudjelal, James W. Zapf
Abstract: The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia:
Type:
Grant
Filed:
November 15, 2002
Date of Patent:
July 4, 2006
Assignees:
Incyte San Diego Incorporated, Ortho McNeil Pharmaceutical Inc.
Inventors:
Magnus Pfahl, Catherine Tachdjian, Lyle W. Spruce, Hussien A. Al-Shamma, Mohamed Boudjelal, Andrea N. Fanjul, Torsten R. Wiemann, David P. M. Pleynet
Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
Type:
Grant
Filed:
July 19, 2004
Date of Patent:
December 13, 2005
Assignees:
Incyte San Diego Inc., Ortho McNeil Pharmaceutical Inc.
Inventors:
Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul, David P. M. Pleynet, Lyle W. Spruce
Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
Type:
Grant
Filed:
December 31, 2002
Date of Patent:
July 20, 2004
Assignee:
Incyte San Diego
Inventors:
Magnus Pfahl, Catherine Tachdjian, Hussien A. Al-Shamma, Andrea Fanjul, David P. M. Pleynet, Lyle W. Spruce