Patents Assigned to Infigen, Inc.
  • Immune response replication in cloned animals
    Publication number: 20040055025
    Abstract: The present invention provides a method and materials for reproducing an immune response of a mammal against one or more antigens of interest. The method preferably involves cloning a founder mammal and producing an immune response in the clone that is substantially identical to the immune response of the founder animal to the antigen or antigens of interest. Accordingly, a source of valuable antibodies can be maintained despite the death or illness of the antibody producing animal.
    Type: Application
    Filed: January 30, 2003
    Publication date: March 18, 2004
    Applicant: Infigen, Inc.
    Inventors: Erik J. Forsberg, Gregory H. Leno, Jeffrey Betthauser, Kenneth Eilertsen, Michael D. Bishop
  • Method of cloning porcine animals
    Patent number: 6700037
    Abstract: The present invention relates to materials and methods for cloning porcine animals. The invention relates in part to totipotent cells useful for cloning porcine animals, porcine embryos produced from such cells by employing nuclear transfer techniques, and porcine animals that arise from such cells and embryos.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: March 2, 2004
    Assignee: Infigen, Inc.
    Inventors: Philip Damiani, Jeffrey M. Betthauser, Erik J. Forsberg, Michael D. Bishop
  • In vitro activation of mammalian oocytes
    Patent number: 6680199
    Abstract: A process of parthenogenic activation of mammalian oocytes which includes increasing intercellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducing Ca2+free cation, such as ionomycin, to the oocyte and then preventing phosphorylation of the cellular proteins within the oocyte by adding a serine-threonine kinase inhibitor, such as 6-dimethylaminopurine (DMAP).
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: January 20, 2004
    Assignee: Infigen, Inc.
    Inventors: Joan L. Susko-Parrish, David L. Northey, M. Lorraine Leibfried-Rutledge, Steven L. Stice
  • Method of cloning animals
    Patent number: 6603059
    Abstract: The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using nuclear transfer techniques, animals that arise from these cells and embryos, and materials, methods, and processes for establishing such cells, embryos, and animals.
    Type: Grant
    Filed: October 16, 2000
    Date of Patent: August 5, 2003
    Assignee: Infigen, Inc.
    Inventors: Nikolai S. Strelchenko, Jeffrey M. Betthauser, Gail L. Jurgella, Marvin M. Pace, Michael D. Bishop
  • Method of cloning animals
    Publication number: 20030070186
    Abstract: The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using nuclear transfer techniques, animals that arise from these cells and embryos, and materials, methods, and processes for establishing such cells, embryos, and animals.
    Type: Application
    Filed: May 22, 2002
    Publication date: April 10, 2003
    Applicant: Infigen, Inc.
    Inventors: Nikolai S. Strelchenko, Jeffrey M. Betthauser, Gail L. Jurgella, Marvin M. Pace, Michael D. Bishop
  • Method of producing a polypeptide in an ungulate
    Patent number: 6395958
    Abstract: The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using nuclear transfer techniques, animals that arise from these cells and embryos, and materials, methods, and processes for establishing such cells, embryos, and animals.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: May 28, 2002
    Assignee: Infigen, Inc.
    Inventors: Nikolai S. Strelchenko, Jeffrey M. Betthauser, Gail L. Jurgella, Marvin M. Pace, Michael D. Bishop
  • Method of cloning porcine animals
    Patent number: 6258998
    Abstract: The present invention relates to materials and methods for cloning porcine animals. The invention relates in part to totipotent cells useful for cloning porcine animals, porcine embryos produced from such cells by employing nuclear transfer techniques, and porcine animals that arise from such cells and embryos.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: July 10, 2001
    Assignee: Infigen, Inc.
    Inventors: Philip Damiani, Jeffrey M. Betthauser, Erik J. Forsberg, Michael D. Bishop
  • Parthenogenic oocyte activation
    Patent number: 6194202
    Abstract: A process of parthenogenic activation of mammalian oocytes which includes increasing intracellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducing Ca2+ free cation, such as ionomycin, to the oocyte and then preventing phosphorylation of the cellular proteins within the oocyte by adding a serine-threonine kinase inhibitor, such as 6-dimethylaminopurine (DMAP).
    Type: Grant
    Filed: March 4, 1996
    Date of Patent: February 27, 2001
    Assignee: Infigen, Inc.
    Inventors: Joan L. Susko-Parrish, David L. Northey, M. Lorraine Leibfried-Rutledge, Steven L. Stice
  • Culture of totipotent embryonic inner cells mass cells and production of bovine animals
    Patent number: 6107543
    Abstract: The use of totipotent embryonic stem cells to provide substantially identical cells for embryo cloning techniques is described. The method includes the culture of loose suspensions of inner cell mass cells of bovine animals to retrieve large populations of stem cells. The invention also describes the use of stem cells in various genetic manipulation techniques.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: August 22, 2000
    Assignee: Infigen, Inc.
    Inventors: Michelle M. Sims, Neal L. First
  • Parthenogenic oocyte activation
    Patent number: 6077710
    Abstract: A process of parthenogenic activation of mammalian oocytes which includes increasing intracellular levels of divalent cations in the oocyte; and reducing phosphorylation of cellular proteins in the oocyte. One method of accomplishing this is by introducing Ca.sup.2+ free cation, such as ionomycin, to the oocyte and then preventing phosphorylation of the cellular proteins within the oocyte by adding a serine-threonine kinase inhibitor, such as 6-dimethylaminopurine (DMAP).
    Type: Grant
    Filed: October 21, 1998
    Date of Patent: June 20, 2000
    Assignee: Infigen, Inc.
    Inventors: Joan L. Susko-Parrish, David L. Northey, M. Lorraine Leibfried-Rutledge, Steven L. Stice
  • Method of cloning bovines using reprogrammed non-embryonic bovine cells
    Patent number: 6011197
    Abstract: The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using nuclear transfer techniques, animals that arise from these cells and embryos, and materials, methods, and processes for establishing such cells, embryos, and animals.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: January 4, 2000
    Assignee: Infigen, Inc.
    Inventors: Nikolai S. Strelchenko, Jeffrey M. Betthauser, Gail L. Jurgella, Marvin M. Pace, Michael D. Bishop