Patents Assigned to Infinity Pharmaceuticals, Inc.
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7566706
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: July 28, 2009
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Publication number: 20080306127
    Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: November 15, 2006
    Publication date: December 11, 2008
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo Castro, Edward Holson, Brian Hopkins, Nii Koney, Daniel Snyder, Thomas Tibbitts
  • Cyclopamine analogues and methods of use thereof
    Patent number: 7407967
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: August 5, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7375217
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: May 20, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7361647
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 22, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Patent number: 7282493
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 16, 2007
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina T. Georges Evangelinos, Louis Grenier, Roger H. Pak, James R. Porter, James L. Wright
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Publication number: 20070161690
    Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: November 15, 2006
    Publication date: July 12, 2007
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo Castro, Edward Holson, Brian Hopkins, Nii Koney, Daniel Snyder, Thomas Tibbitts
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Publication number: 20070155705
    Abstract: The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: December 15, 2006
    Publication date: July 5, 2007
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo Castro, Michael Grogan, Edward Holson, Brian Hopkins, Nii Koney, Stephane Peluso, Daniel Snyder
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Publication number: 20060025460
    Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: June 17, 2005
    Publication date: February 2, 2006
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo Castro, Wei Deng, Kristopher Depew, Michael Foley, Christian Fritz, Asimina Georges Evangelinos, Michael Grogan, Nafeeza Hafeez, Edward Holson, Brian Hopkins, Nii Koney, Tao Liu, David Mann, Lisa Marcaurelle, Daniel Snyder, Dennis Underwood, Andrew Wylie, Lin-Chen Yu, Linping Zhang
  • Isoxazolidine compounds for treatment of bacterial infections
    Publication number: 20060020004
    Abstract: The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.
    Type: Application
    Filed: June 17, 2005
    Publication date: January 26, 2006
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Burton Christensen, Michael Foley, Asimina Georges Evangelinos, Tao Liu, James Porter, Amy Ripka, Linping Zhang
  • Analogs of benzoquinone-containing ansamycins and methods of use thereof
    Publication number: 20060019941
    Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
    Type: Application
    Filed: July 13, 2005
    Publication date: January 26, 2006
    Applicant: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yun Gao, Asimina Evangelinos, Louis Grenier, Roger Pak, James Porter, James Wright