Abstract: The present invention relates generally to the field of bacteriology. More particularly, the present invention provides methods and compositions for increasing the effectiveness of existing antibacterial agents and methods of overcoming bacterial resistance. Specifically, the invention provides methods of enhancing the action of an antibacterial agent by use of an antibiotic potentiator. Compositions of antibiotic potentiators including an acyl hydrazide, an oxy amide, and an 8-hydroxy quinoline also are disclosed.
Type:
Application
Filed:
March 23, 2001
Publication date:
December 4, 2003
Applicant:
Influx, Inc.
Inventors:
Penelope N. Markham, Debbie C. Mulhearn, Ekaterina A. Klyachko, Alexander A. Neyfakh, David Crich, Mohamed-Rami Jaber, Michael E. Johnson
Abstract: The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically, the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.
Type:
Application
Filed:
March 26, 2002
Publication date:
July 3, 2003
Applicant:
Influx, Inc.
Inventors:
Penelope N. Markham, Debbie C. Mulhearn, Alexander A. Neyfakh, David Crich, Mohamad-Rami Jaber, Michael E. Johnson
Abstract: The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically, the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.
Type:
Grant
Filed:
August 17, 2000
Date of Patent:
March 26, 2002
Assignee:
Influx, Inc.
Inventors:
Penelope N. Markham, Debbie C. Mulhearn, Alexander A. Neyfakh, David Crich, Mohamad-Rami Jaber, Michael E. Johnson
Abstract: The present invention relates generally to the fields of bacteriology and mycology. More particularly, the present invention provides novel inhibitors of multidrug transport proteins that may be used in combination with existing antibacterial agent and/or antifungal agents to increase the toxic effects of the antimicrobial agents. More specifically the present invention provides methods and compositions for enhancing the antibacterial action of fluoroquinolones by administering fluoroquinolones in combination with an inhibitor of multidrug transporters and of enhancing the antifungal action of azole antifungal agents by administering an azole antifungal agent in combination with an inhibitor of multidrug transporters. Compositions comprising indole, urea, quinoline or aromatic amide based inhibitors also are disclosed.
Type:
Grant
Filed:
December 2, 1999
Date of Patent:
December 4, 2001
Assignee:
Influx, Inc.
Inventors:
Penelope N. Markham, Debbie C. Mulhearn, Alexander A. Neyfakh, David Crich, Mohamad-Rami Jaber, Michael E. Johnson
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