Abstract: A displaceable valved stopper is disclosed which partitions a conventional syringe into proximal and distal chambers to provide a multi-chamber, mixing syringe assembly. Also the valved stopper and a valve assembly are disclosed for use in a single conventional syringe to provide dual chamber mixing plus a disparate and sequentially dispensed flush. Incorporated in the valve assembly is another valved stopper and a separator which filters out gas from liquid being dispensed through the valve assembly. Each valved stopper is made as a single molded part which may be made from basic syringe plunger material. Also, each valved stopper may have a bi-state valve (e.g. a domed, slit valve). The separator is a single molded part which may be molded from basic syringe material. Each valve is actuated to a different state by differential pressure of a force greater than the associated valved stopper displacement force.

Abstract: A valve assembly is disclosed which partitions a conventional syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. Incorporated in the valve assembly is a valved stopper having a valve (e.g. a slit valve) and a separator which filters out gas from liquid being dispensed through the valve assembly. A syringe plunger communicates through fluid in the proximal chamber to force displacement of the valve assembly. The valve is actuated by differential pressure of a force greater than the valve assembly displacement force. The valve assembly may be made from two parts: (1) a valved stopper (may be molded from basic syringe plunger material); (2) a separator (may be injection molded from syringe barrel material).

Abstract: A valve assembly is disclosed which effectively partitions a syringe into proximal and distal chambers to provide a multi-chamber, sequentially dispensing syringe apparatus. The valve assembly may be effectively used with a variety of standard, currently available commercial syringes and pre-filled syringes. Incorporated in the valve assembly is a valved stopper having a valve (which may be a slit valve), an impact sensor which opens the valve upon impact between the valve assembly and internal distal end of the syringe and a gas separator which separates liquid from gas disposed in the proximal chamber to assure gas is not delivered therefrom. The valve assembly is displaced as a plunger of the syringe is displaced via communication through fluid in the proximal chamber of the syringe. The actuator has a latching feature which latches the valve to an open state after being opened by the impact sensor. The gas separator has a proximally disposed orifice which facilitates priming.