Abstract: A compact, mobile communicating carrying case for the transport and storage of temperature-sensitive materials. The carrying case regulates to temperature presets that can be altered real time directly or remotely. Cryogenic temperature control is provided by use of a low boiling point liquid coolant, like liquid nitrogen or air that accelerates in a multicore cooling system. A microprocessor-controlled double function solenoid acting as a valve and sensor, temperature sensors, and several mechanical one way release valves regulate the cooling system. Peripheral integrated modules collect, send, receive and display information on the case and on smart devices about location, core temperature, the carrier and the nature of the enclosed material. The carrying case provides a compact laser-etched sterile working area, in addition to a set of basic instruments, needed for procedures using the biological materials.