Patents Assigned to Instillo GmbH
  • Publication number: 20190030497
    Abstract: The invention relates to a method for preparing emulsions. In order to create a new method for preparing emulsions, in which homogenous oil droplets as small as possible can be generated with an energy input as low as possible, it is proposed in the scope of the invention, that at least two liquid streams of liquids that cannot be intermixed with one another are pumped through separate openings with defined diameters, in order to achieve flow velocity of the liquid streams of more than 10 m/sec., and in that the liquid streams collide at a collision point in a space, wherein the resulting emulsion is discharged from the space through an outlet. By the collision of the liquid streams with high flow velocities, in which a plate-shaped collision plate is formed in the collision point, a homogenous emulsion having an oil droplet size of less than 1 ?m is achieved due to the kinetic energy, which is accordingly very stable as well. No further energy input, such as shear forces, is required to that end.
    Type: Application
    Filed: January 25, 2017
    Publication date: January 31, 2019
    Applicant: Instillo GmbH
    Inventors: Bernd BAUMSTUEMMLER, Hermann SCHIRRA, Akif Emre TUERELI
  • Patent number: 9901893
    Abstract: The invention relates to an apparatus and method for the production of dispersions and solids by way of controlled precipitation, co-precipitation and self-organization processes in a microjet reactor, a jet of solvent containing at least one target molecule and a jet of nonsolvent colliding with each other, at specified pressures and flow rates, at a collision point in the reactor chamber of the microjet reactor, and the microjet reactor having a gas inlet for introducing gas into the reactor chamber and an educt outlet for discharging the educts in a stream of gas. This results in very rapid precipitation, co-precipitation or a chemical reaction, during the course of which micro- or nanoparticles form.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: February 27, 2018
    Assignee: Instillo GmbH
    Inventors: Bernd Penth, Felix Penth, Bernd Baumstuemmler, Akif Emre Tuereli
  • Publication number: 20160051956
    Abstract: The invention relates to an apparatus and method for the production of dispersions and solids by way of controlled precipitation, co-precipitation and self-organisation processes in a microjet reactor, a jet of solvent containing at least one target molecule and a jet of nonsolvent colliding with each other, at specified pressures and flow rates, at a collision point in the reactor chamber of the microjet reactor, and the microjet reactor having a gas inlet for introducing gas into the reactor chamber and an educt outlet for discharging the educts in a stream of gas. This results in very rapid precipitation, co-precipitation or a chemical reaction, during the course of which micro- or nanoparticles form.
    Type: Application
    Filed: March 28, 2014
    Publication date: February 25, 2016
    Applicant: Instillo GmbH
    Inventors: Bernd PENTH, Felix PENTH, Bernd BAUMSTUEMMLER, Akif Emre TUERELI
  • Patent number: 8852644
    Abstract: The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: October 7, 2014
    Assignee: Instillo GmbH
    Inventors: Bernd Baumstuemmler, Bernd Penth, Felix Penth, Akif Emre Tuereli
  • Patent number: 8697131
    Abstract: Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: April 15, 2014
    Assignee: Instillo GmbH
    Inventors: Akif Emre Tuereli, Bernd Penth, Peter Langguth, Bernd Baumstuemmler