Patents Assigned to Institut National de la Recherche Agronomique (Inra)
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Patent number: 11717543Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.Type: GrantFiled: June 22, 2020Date of Patent: August 8, 2023Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, ECOLE D'INGENIEURS DE PURPANInventors: Philippe Langella, Sylvie Miquel, Rebeca Martin Rosique, Luis Bermudez Humaran, Muriel Thomas, Harry Sokol, Frédéric Carvalho, Vassilia Theodorou
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Patent number: 11498942Abstract: The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.Type: GrantFiled: December 20, 2017Date of Patent: November 15, 2022Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTUREInventors: John P. Bannantine, Gilles Etienne, Sylvie Bay, Franck Biet
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Patent number: 11484569Abstract: The invention concerns a Reg3? polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for use in the protection of oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide and their use. The inventors have shown that an increase in the concentration of the h Reg3? lectin into the gastrointestinal tract (GIT) lumen of hReg3?-transgenic mice induced significant changes in the composition of the gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3? exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and in particular the ROS scavenging activity, in particular, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that h Reg3?-transgenic mice resist better to DSS-induced colitis after antibiotherapy.Type: GrantFiled: July 13, 2018Date of Patent: November 1, 2022Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), UNIVERSITÉ PARIS-SUDInventors: Joël Dore, Jamila Faivre, Nicolas Moniaux, Christian Brechot, Marion Darnaud
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Publication number: 20220295840Abstract: A modulated protein composition is described with improved flavor properties over a vegetable protein. Methods of making a modulated protein composition including the use of a volatile modulating yeast culture to ferment a vegetable protein to produce the modulated protein composition are described. Also disclosed are a fermented vegetable composition made from a modulated protein composition, and ingredients and foods including a fermented vegetable composition or a modulated protein composition.Type: ApplicationFiled: July 31, 2019Publication date: September 22, 2022Applicants: SODIMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT DES SCIENCES ET INDUSTRIES DU VIVANT ET DE L'ENVIRONNEMENTInventors: Sébastien Fraud, Cynthia El Youssef, Pascal Bonnarme, Sophie Landaud-Liautaud, Sandra Helinck
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Patent number: 11445671Abstract: The present invention concerns an isolated polynucleotide responsible of haploid induction in maize plants and related processes. Additionally, the invention relates to plants that have been genetically transformed with the polynucleotide of the invention. The invention also relates to a process for screening a mutant plant population for enhanced haploid induction by using said isolated polynucleotide. The invention further relates to molecular markers associated with haploid induction in maize plants and their use in quality control for inducer lines.Type: GrantFiled: May 6, 2016Date of Patent: September 20, 2022Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), LIMAGRAIN EUROPE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Jean-Pierre Martinant, Jordi Comadran, Jean-Baptiste Laffaire, Peter Rogowsky, Thomas Widiez
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Patent number: 11341594Abstract: Apparatus to acquire an image of roots of a plant located in a target rhizotron. The apparatus includes: a turntable having a rotation axis and intended to support the target rhizotron; a lightening device; a first camera having an optical axis substantially oriented toward the rotation axis; a focus sensor arranged so as to provide a measure at least one parameter of the first camera; a control module, configured to receive the measure, compare the measure to comparison data, and inform an operator accordingly, the comparison data comprising data related to reference rhizotrons different than the target rhizotron, and/or data related to one or several previously acquired images of the target rhizotron.Type: GrantFiled: May 29, 2018Date of Patent: May 24, 2022Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INOVIAFLOWInventors: Christophe Salon, Christian Jeudy, Christophe Baussart, Fédéric Chazallet, Mickael Lamboeuf, Julien Martinet
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Publication number: 20210077574Abstract: The present invention relates to a phycocyanin composition for use in inhibiting bone resorption in humans or animals.Type: ApplicationFiled: June 5, 2018Publication date: March 18, 2021Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)Inventors: Véronique COXAM, Marie-Jeanne DAVICCO, Laurent LEOTOING, Fabien WAUQUIER
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Patent number: 10918678Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.Type: GrantFiled: January 23, 2017Date of Patent: February 16, 2021Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARISInventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
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Patent number: 10837030Abstract: The invention relates to a method for propagating yeast, for use in the production of a fermentation product from lignocellulosic biomass, including the steps that consist of: a. providing a reactor; b. placing in contact in said reactor: a population of yeasts capable of metabolising pentoses and hexoses, with 0.2 to 2.0 g of yeast solids per kg of prepared complete medium, raw marc from the pretreatment of the lignocellulosic biomass, with a solids content (MS) of 8% to 15%, nutrients, and cellulases, with 5 to 15 mg of proteins per gram of MS; and c. incubating the mixture at a temperature of 25° C. to 38° C., preferably 28° C. to 33° C., in microaerobiosis, in which the saccharification of the raw marc and the growth of the yeast are carried out simultaneously.Type: GrantFiled: May 26, 2016Date of Patent: November 17, 2020Assignees: LESAFFRE ET COMPAGNIE, AGRO INDUSTRIE RECHERCHES ET DEVELOPPEMENTS A.R.D., INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRAInventor: Flora Ghisoni
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Patent number: 10736925Abstract: The present invention relates to a method of selecting or identifying probiotic strains capable of acting on the absorption of water in the colon, and use thereof as medicinal products in the treatment and/or prevention of diarrhea. The invention relates in particular to the strain of Bacillus subtilis CU1 for use in the treatment and/or prevention of diarrhea.Type: GrantFiled: October 10, 2018Date of Patent: August 11, 2020Assignees: LESAFFRE ET COMPAGNIE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA, ECOLE NATIONALE SUPERIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE (BORDEAUX SCIENCES AGRO)Inventors: Marie Khuong Huu, Jean Fioramonti, Maria Urdaci
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Patent number: 10723999Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.Type: GrantFiled: December 19, 2014Date of Patent: July 28, 2020Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYONInventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
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Patent number: 10695403Abstract: The present invention relates to an FGF19 polypeptide for use in increasing muscle fiber size in the treatment of muscle atrophy in a mammal.Type: GrantFiled: June 24, 2016Date of Patent: June 30, 2020Assignees: Universite Claude Bernard Lyon, Institut National de la Recherche Agronomique (INRA), Institut National de la Santè et de la Recherche Médicale (INSERM), Bergen Teknologioverforing ASInventors: Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Jérome Ruzzin
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Publication number: 20200188533Abstract: A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.Type: ApplicationFiled: December 26, 2019Publication date: June 18, 2020Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Pierre FAFOURNOUX
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Publication number: 20200157591Abstract: Celluloses, notably nanocelluloses, and more particularly processes for manufacturing cellulose fibers and for defibrillating cellulose-based substrates. Most particularly, processes for defibrillating cellulose-based substrates and manufacturing celluloses, in particular nanocelluloses (NC), using a new family of fungal lytic polysaccharide monooxygenases (LPMOs).Type: ApplicationFiled: July 31, 2018Publication date: May 21, 2020Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)Inventors: Bernard CATHALA, Jean-Guy BERRIN, Ana VILLARES, Céline MOREAU
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Patent number: 10519463Abstract: Plants of the Cucurbitaceae family and seeds of such plants with an androecious phenotype, whereas this sexual type is not natural in the plants, and the use of the plants and of the plant seeds of the invention. Moreover, the nucleic acid sequence responsible for androecy in the plants of the invention and on the polypeptide encoded by the nucleic acid sequence. Finally, methods of identifying the plants and the seeds.Type: GrantFiled: January 16, 2013Date of Patent: December 31, 2019Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), VILMORIN ET CIEInventors: Abdelhafid Bendahmane, Christelle Troadec, Adnane Boualem, Daniele Hosemans, Julie Fauve
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Publication number: 20190381115Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.Type: ApplicationFiled: November 13, 2015Publication date: December 19, 2019Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), ECOLE D'INGENIEURS DE PURPANInventors: Philippe LANGELLA, Sylvie MIQUEL, Rebeca MARTIN ROSIQUE, Luis BERMUDEZ HUMARAN, Muriel THOMAS, Harry SOKOL, Frédéric CARVALHO, Vassilia THEODOROU
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Publication number: 20190150338Abstract: A new apple tree named ‘Inobi’ notable for its attractive fruit, favorable organoleptic qualities and resistance to apple scab. Fruit of ‘Inobi’ is highly colored and has a long shelf life.Type: ApplicationFiled: November 13, 2018Publication date: May 16, 2019Applicants: NOVADI SARL, Institut National de la Recherche Agronomique (INRA)Inventor: Christelle Pitiot
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Patent number: 10287326Abstract: Disclosed is a polypeptide including or consisting of the amino acid sequence SEQ id no:1, for use in the treatment or prevention of an inflammatory disease. It further encompasses a nucleic acid sequence encoding a polypeptide, a vector including a nucleic acid and a host cell including a nucleic acid sequence and/or a vector, for use in the treatment or prevention of an inflammatory disease. Also disclosed is a pharmaceutical composition or a food composition including a polypeptide, a nucleic acid sequence, a vector or a host cell and a pharmaceutically acceptable carrier or a dairy product, for the treatment of inflammatory disease. Additionally, a method for the screening of bacteria having immunomodulatory properties is disclosed.Type: GrantFiled: July 7, 2015Date of Patent: May 14, 2019Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT PASTEUR DE LILLE (IPL)Inventors: Gwenael Jan, Benoit Foligne, Helene Falentin, Stephanie-Marie Deutsch
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Publication number: 20190134224Abstract: A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.Type: ApplicationFiled: June 2, 2017Publication date: May 9, 2019Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Pierre FAFOURNOUX
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Patent number: PP31287Abstract: A new apple tree named ‘Inobi’ notable for its attractive fruit, favorable organoleptic qualities and resistance to apple scab. Fruit of ‘Inobi’ is highly colored and has a long shelf life.Type: GrantFiled: November 13, 2018Date of Patent: December 31, 2019Assignees: Novadi SARL, Institut National de la Recherche Agronomique (INRA)Inventors: Christelle Pitiot, François Laurens