Patents Assigned to Institute for Medical Informatics
  • Optimizing the initialization and convergence of active contours for segmentation of cell nuclei in histological sections
    Patent number: 8942441
    Abstract: A computer-implemented segmentation method is used to process an image representing a plurality of nuclei. The method is implemented in a computer having a processor and a physical memory. A set of instructions are provided to the processor the physical memory of the computer. The processor is configured by executing the set of instructions in the physical memory so as to automatically segment the image by: thresholding a grey-scale image to create a black and white image; identifying objects in the black and white image and removing objects failing to meet predetermined criteria; extracting objects; and applying an edge detector on the segmented image to identify the edges of the nuclei. Overlapping nuclei are split to improve results.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: January 27, 2015
    Assignee: Institute for Medical Informatics
    Inventors: Birgitte Nielsen, John Maddison, Havard Danielsen
  • Microscopy analysis technique
    Patent number: 8467590
    Abstract: A method and apparatus for the analysis of cell nuclei may use a system where images captured from a bright field microscope are analysed and information is retrieved that give quantitative information of the different type of chromatin within the cell nuclei for example Hetrochromatin and Euchromatin. The method is based on segmented cell nuclei. Quantitative information is determined related to the greyscale distribution of the different areas of the chromatin types and the object structure within these different areas.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: June 18, 2013
    Assignee: Institute for Medical Informatics
    Inventors: John Maddison, Havard Danielsen
  • Microscopy Analysis Technique
    Publication number: 20120114216
    Abstract: A method and apparatus for the analysis of cell nuclei may use a system where images captured from a bright field microscope are analysed and information is retrieved that give quantitative information of the different type of chromatin within the cell nuclei for example Hetrochromatin and Euchromatin. The method is based on segmented cell nuclei. Quantitative information is determined related to the greyscale distribution of the different areas of the chromatin types and the object structure within these different areas.
    Type: Application
    Filed: June 2, 2011
    Publication date: May 10, 2012
    Applicant: Institute for Medical Informatics
    Inventors: John MADDISON, Havard Danielsen
  • OPTIMIZING THE INITIALIZATION AND CONVERGENCE OF ACTIVE CONTOURS FOR SEGMENTATION OF CELL NUCLEI IN HISTOLOGICAL SECTIONS
    Publication number: 20110274336
    Abstract: A computer-implemented segmentation method is used to process an image representing a plurality of nuclei. The method is implemented in a computer having a processor and a physical memory. A set of instructions are provided to the processor the physical memory of the computer. The processor is configured by executing the set of instructions in the physical memory so as to automatically segment the image by: thresholding a grey-scale image to create a black and white image; identifying objects in the black and white image and removing objects failing to meet predetermined criteria; extracting objects; and applying an edge detector on the segmented image to identify the edges of the nuclei. Overlapping nuclei are split to improve results.
    Type: Application
    Filed: March 11, 2011
    Publication date: November 10, 2011
    Applicant: Institute for Medical Informatics
    Inventors: Birgitte Nielsen, John Maddison, Harvard Danielsen