Patents Assigned to Institute for OneWorld Health
  • Compounds, compositions and methods comprising pyrazole derivatives
    Patent number: 8343976
    Abstract: The present invention relates to compounds, compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas Ia, Ib, IIa, and IIb) or compositions comprising these compounds, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: January 1, 2013
    Assignee: Institute for OneWorld Health
    Inventors: Stephen David Penrose, Kevin James Doyle
  • Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
    Patent number: 8283351
    Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of the functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a cyclic or acyclic hydrazine derivative including those of formulas II or III: or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: October 9, 2012
    Assignee: Institute for OneWorld Health
    Inventors: Michael Geoffrey Neil Russell, Huw David Vater, Jacqueline Anne Macritchie, Kevin James Doyle, David Brown, Joanne Peach
  • Compounds, compositions and methods comprising isoxazole derivatives
    Patent number: 8236838
    Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: August 7, 2012
    Assignee: Institute for OneWorld Health
    Inventors: Graham Peter Jones, Kevin James Doyle
  • Compounds, compositions and methods comprising oxadiazole derivatives
    Patent number: 8207205
    Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: June 26, 2012
    Assignee: Institute for OneWorld Health
    Inventors: Graham Peter Jones, Kevin James Doyle
  • COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES
    Publication number: 20110237528
    Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formulas (I), (IA), (IB), (II), and (III)) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.
    Type: Application
    Filed: September 16, 2009
    Publication date: September 29, 2011
    Applicant: INSTITUTE FOR ONEWORLD HEALTH
    Inventors: Graham Peter Jones, Kevin James Doyle
  • Transgenic amorpha-4, 11-diene synthesis
    Patent number: 7541172
    Abstract: The present invention relates to an isolated DNA sequence encoding a polypeptide having the biological activity of amorpha-4,11-diene synthase. This DNA sequence can be used for the transformation of bacteria, yeasts and plants for the production of amorpha-4,11-diene, a specific precursor in the synthesis of artemisinin, in the respective organisms. The invention also relates to these organisms.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: June 2, 2009
    Assignee: Institute for OneWorld Health
    Inventors: Thorvald Eelco Wallaart, Hendrik Jan Bouwmeester