Patents Assigned to Institute of MacroMolecular Chemistry
  • Publication number: 20230381112
    Abstract: An amphiphilic block copolymer having any one of the formulas D-S—H, S(D)-H, S—H(D), D-S—H—S, D-S—H—S-D, S(D)-H—S, S(D)-H—S(D) or S—H(D)-S is disclosed. S is a hydrophilic block; H is a hydrophobic block; D is a drug molecule; ( ) denotes that the group is bonded directly or indirectly as a side chain or as part of a side chain group to the adjacent group; and the hyphen, “-” (or sometimes “-”), denotes that each of the adjacent S, H or D are linked either directly to one another or indirectly to one another via a linker, additionally wherein the hydrophilic block comprises a first hydrophilic monomer and the hydrophobic block comprises a first hydrophobic monomer and a second hydrophobic monomer.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 30, 2023
    Applicants: Vaccitech North America, Inc., Institute of Macromolecular Chemistry
    Inventors: Geoffrey Martin Lynn, David Robert Wilson, Ellen Wang, Kyle James Fergie, Lucie Woldrichová, Ladislav Androvic, Richard Laga
  • Publication number: 20230026627
    Abstract: A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.
    Type: Application
    Filed: April 16, 2020
    Publication date: January 26, 2023
    Applicants: Vaccitech North America, Inc., Institute of Macromolecular Chemistry, The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Geoffrey Lynn, Yaling Zhu, Jacob Holechek, David Wilson, Joe Francica, Richard Laga, Gabriela Muzíková
  • Patent number: 8241402
    Abstract: A method of separation of hydrogen from gas mixtures consisting in that a gas mixture (3) with any hydrogen content is introduced into a closed space (4), in which a polymer foam (1) containing non-communicating pores (2) is placed. Due to the fact that the hydrogen partial pressure in pores (2) of the polymer foam (1) is lower, hydrogen penetrates into the pores. Hence, the gas mixture (3) leaving the closed space (4) is deficient in the hydrogen. The inlet of the gas mixture (3) into the closed space (4) can be interrupted at the time when the leaving mixture has the same composition as the introduced gas mixture (3) or earlier. Then the pressure in the closed space (4) is decreased and, due to the leveling of its partial pressure, hydrogen is released from the polymer foam (1) and can be received for further use. Its concentration is higher than in the starting gas mixture (3).
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: August 14, 2012
    Assignee: Institute of Macromolecular Chemistry AS CR, V.V.I.
    Inventor: Zbynek Pientka
  • Patent number: 6610284
    Abstract: A preparation for prevention and healing of inflammation affections comprising in an amount of 0.1 to 99.9% by weight derivatives of sterically hindered amines selected from the group consisting of: soluble polymers or copolymers prepared by radical polymerization in the presence of 0.01 to 10% by weight, of initiators prepared:in a polymerization mixture comprising individually or in combination an aliphatic amine monomer of the general formula (A), soluble polymers or copolymers prepared by radical polymerization in the presence of 0.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: August 26, 2003
    Assignee: Institute of MacroMolecular Chemistry
    Inventors: Ji{haeck over (r)}í Labský, Ji{haeck over (r)}í Vacík, Pavel Ho{haeck over (s)}ek
  • Patent number: 6590061
    Abstract: Functionalized homopolymers and copolymers of &agr;-amino acids of the general formula 1, wherein X is oxygen or sulphur; R1 could be alkyl, alkenyl, substituted alkyl, aryl or substituted aryl; structure [A]n represents a poly(amino acid) chain based on &agr;-amino acids or their derivatives with protected functional groups, wherein n could be in the range of 1-500; Y is either OH, or a structure of the formula 2, wherein R2 is H or an amino-acid residue, or a structure of the formula 3, wherein Z and Z′ are either NH or O; R3 is a chemical structure selected from alkyls, substituted alkyls, aryls, substituted aryls, or a polymer selected from a group comprising poly(ethylene oxide), poly(propylene oxide) and polybutadiene; P is hydrogen or an acyl group derived from a carboxylic acid selected from the group including alkanoic acids, succinic acid, maleic acid, acrylic acid, phthalic acids and cyclohexane dicarboxylic acids, or it is an acyl selected from a group consisting of compounds accor
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: July 8, 2003
    Assignee: Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic
    Inventors: Frantisek Rypacek, Milan Dvorak, Dana Kubies, Ludka Machova
  • Patent number: 5244673
    Abstract: A medicamentous form or composition with antiexudation, antiphlogistic, and antimicrobial effects in an aqueous or ointment base, suitable above all as an ophthalmologic, otolaryngologic, or dermatologic drug contains inhibitors of proteases such as aprotinin, soybean trypsine inhibitor, and elastatinal either single or in combination. The composition may further comprise steroidal or. The composition may further include steroidal or nonsteroidal antiphlogistics and/or antibiotics.
    Type: Grant
    Filed: September 26, 1990
    Date of Patent: September 14, 1993
    Assignee: Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic
    Inventors: Jitka Gejkova, Jiri Vacik, Zdenek Lojda