Abstract: A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets.
Type:
Grant
Filed:
August 3, 2015
Date of Patent:
August 7, 2018
Assignees:
ETH ZURICH, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I
Inventors:
Vaclav Matousek, Petr Beier, Antonio Togni
Abstract: A hypervalent iodine of formula (I) or formula (II) wherein R is a nucleophile and a method for their production is described. Such compounds can be used for fluoroethylation of compounds carrying a reactive group. A preferred compound carrying a reactive group is cystein in any environment such as peptide targets.
Type:
Application
Filed:
August 3, 2015
Publication date:
August 17, 2017
Applicants:
ETH Zurich, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I
Inventors:
Vaclav MATOUSEK, Petr BEIER, Antonio TOGNI