Patents Assigned to Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.
  • 3?3?-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
    Patent number: 11766447
    Abstract: The present disclosure relates to 3?3?-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: September 26, 2023
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Petra Brehova, Milan Dejmek, Radim Nencka, Ondrej Pav, Michal Sala
  • 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR
    Publication number: 20220160746
    Abstract: The present disclosure relates to 3?3?-cyclic dinucleotides having a carbocyclic nucleotide and derivatives that can modulate the activity of the STING adaptor protein.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 26, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I
    Inventors: Gabriel BIRKUS, Petra BREHOVA, Milan DEJMEK, Radim NENCKA, Ondrej PAV, Michal SALA
  • 2'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF
    Publication number: 20220152078
    Abstract: The present disclosure relates to 2?3? cyclic phosphonate dinucleotides of Formula (I), the pharmaceutically acceptable salts, pharmaceutical composition and combinations of the substances and other medicaments or pharmaceuticals. The disclosure also relates to the compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 19, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel BIRKUS, Ondrej PAV, Ondrej KOSTOV, Petra BREHOVA, Martin Maxmilian KAISER, Ondrej SIMAK
  • 3'3'-CYCLIC DINUCLEOTIDES AND PRODRUGS THEREOF
    Publication number: 20220143061
    Abstract: The present disclosure relates to 3?3? cyclic phosphonate dinucleotides of general formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of the substances and other medicaments or pharmaceuticals. The disclosure also relates to compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases.
    Type: Application
    Filed: March 4, 2020
    Publication date: May 12, 2022
    Applicant: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel BIRKUS, Ondrej PAV, Petra BREHOVA, Ondrej SIMAK
  • 3?3?-cyclic dinucleotides
    Patent number: 11292812
    Abstract: The present invention relates to 3?3?-cyclic dinucleotides modified with a 3?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: April 5, 2022
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 2?3? cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
    Patent number: 11203610
    Abstract: The present disclosure relates to 2?3? cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: December 21, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • 2?3?-cyclic dinucleotides
    Patent number: 11149052
    Abstract: The present disclosure relates to 2?3?-cyclic dinucleotides modified with a 2?- or 3?-phosphonoalkyl bond and derivatives thereof, that can modulate the activity of the STING adaptor protein.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: October 19, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Ivan Rosenberg, Ondrej Simak
  • 3?3? cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
    Patent number: 10966999
    Abstract: Provided herein are the 3?3? cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 6, 2021
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Gabriel Birkus, Ondrej Pav, Tomas Jandusik, Ivan Rosenberg, Radim Nencka
  • 7-deazapurine nucleosides for therapeutic uses
    Patent number: 10294262
    Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: May 21, 2019
    Assignee: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • 7-deazapurine nucleosides for therapeutic uses
    Patent number: 9624257
    Abstract: The invention provides compounds of formula I: wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: April 18, 2017
    Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Substituted 7-deazapurine ribonucleosides for therapeutic uses
    Patent number: 9586986
    Abstract: Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as compositions which include such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: March 7, 2017
    Assignees: INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I., PALACKY UNIVERSITY IN OLOMOUC
    Inventors: Michal Hocek, Petr Naus, Olga Caletkova, Marian Hajduch, Petr Dzubak
  • NOVEL SUBSTITUTED 7-DEAZAPURINE RIBONUCLEOSIDES FOR THERAPEUTIC USES
    Publication number: 20160159844
    Abstract: Compounds of Formula I and a pharmaceutically acceptable salt thereof, an optical isomer thereof, or a mixture of optical isomers thereof, as well as compositions which include such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 9, 2016
    Applicants: Institute of Organic Chemistry and Biochemistry ASCR, v.v.i., Palacky University in Olomouc
    Inventors: Michal HOCEK, Petr NAUS, Olga CALETKOVA, Marian HAJDUCH, Petr DZUBAK
  • 6-oxopurine phosphoribosyltransferase inhibitors
    Patent number: 9200020
    Abstract: The invention relates to compounds which are useful as inhibitors of 6-oxopurine phosphoribosyltransferases such as hypoxanthine-guanine-(xanthine) phosphoribosyltransferase (HG(X)PRT).
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: December 1, 2015
    Assignees: THE UNIVERSITY OF QUEENSLAND, INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.
    Inventors: John De Jersey, Luke William Guddat, Dana Hockova, Dianne Therese Keough
  • NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES
    Publication number: 20150218201
    Abstract: The invention provides compounds of formula I, wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.
    Type: Application
    Filed: April 19, 2010
    Publication date: August 6, 2015
    Applicant: Institute of Organic Chemistry and Biochemistry ASCR, V.V.I.
    Inventors: Aurelie Bourderioux, Michal Hocek, Petr Naus
  • Cytostatic 7-deazapurine nucleosides
    Patent number: 8093226
    Abstract: The invention provides compounds of formula I: wherein R1 and R2 have any of the values defined in the specification and salts thereof, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: January 10, 2012
    Assignee: Institute of Organic Chemistry and Biochemistry of the ASCR, V.V.I.
    Inventors: Michal Hocek, Petr Naus