Patents Assigned to Instrumentation Laboratory Company
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Publication number: 20200191636Abstract: A fluid aspiration probe apparatus for automatic fluid testing equipment includes a pair of electrodes mounted on a distal probe tip. The electrodes are coupled to an impedance measurement apparatus via conductive pathways along the probe. The impedance measurements and probe tip height are monitored as the probe tip is lowered into a fluid sample. Boundaries between layers of fluid in the container are detected by recognizing sudden changes in the impedance measurements and heights of the boundaries are determined by tracking the position of probe tip when the sudden changes of impedance occur.Type: ApplicationFiled: December 17, 2018Publication date: June 18, 2020Applicant: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Patent number: 10648907Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: May 3, 2019Date of Patent: May 12, 2020Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20200103395Abstract: An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.Type: ApplicationFiled: October 2, 2019Publication date: April 2, 2020Applicant: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Patent number: 10585021Abstract: Described is an automated reagent mixing container for separately storing and automatically mixing together at least two stored reagent components.Type: GrantFiled: August 11, 2016Date of Patent: March 10, 2020Assignee: Instrumentation Laboratory CompanyInventors: Gert Blankenstein, Hansong Zeng
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Patent number: 10578605Abstract: An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel.Type: GrantFiled: December 5, 2018Date of Patent: March 3, 2020Assignee: Instrumentation Laboratory CompanyInventors: Gregory M. Colella, Henry D. Huang, Anthony F. Kuklo, Jr., Dimitri Shishkin, Maria Figueroa, James A. Mawhirt
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Patent number: 10564095Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.Type: GrantFiled: April 18, 2019Date of Patent: February 18, 2020Assignee: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Publication number: 20200047183Abstract: Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Applicant: Instrumentation Laboratory CompanyInventors: Gert Blankenstein, Hansong Zeng
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Patent number: 10456787Abstract: Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.Type: GrantFiled: August 11, 2016Date of Patent: October 29, 2019Assignee: Instrumentation Laboratory CompanyInventors: Gert Blankenstein, Hansong Zeng
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Publication number: 20190293551Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.Type: ApplicationFiled: April 18, 2019Publication date: September 26, 2019Applicant: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Publication number: 20190257750Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: ApplicationFiled: May 3, 2019Publication date: August 22, 2019Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20190234931Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: ApplicationFiled: April 12, 2019Publication date: August 1, 2019Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Patent number: 10324025Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.Type: GrantFiled: May 4, 2018Date of Patent: June 18, 2019Assignee: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Patent number: 10302559Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: December 6, 2018Date of Patent: May 28, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Patent number: 10288600Abstract: Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.Type: GrantFiled: May 15, 2017Date of Patent: May 14, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Gert Blankenstein, Josef Kerimo, Hansong Zeng
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Patent number: 10288556Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.Type: GrantFiled: September 1, 2017Date of Patent: May 14, 2019Assignee: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo
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Publication number: 20190107486Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: ApplicationFiled: December 6, 2018Publication date: April 11, 2019Applicant: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Patent number: 10180419Abstract: An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel.Type: GrantFiled: August 5, 2013Date of Patent: January 15, 2019Assignee: Instrumentation Laboratory CompanyInventors: Gregory M. Colella, Henry D. Huang, Anthony F. Kuklo, Jr., Dimitri Shishkin, Maria Figueroa, James A. Mawhirt
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Patent number: 10168278Abstract: An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.Type: GrantFiled: October 5, 2017Date of Patent: January 1, 2019Assignee: Instrumentation Laboratory CompanyInventors: Ethan Schonbrun, Lara Adib, Gert Blankenstein
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Publication number: 20180345235Abstract: A linear actuator member applies a vertical force to a vessel or to a holding apparatus in which a vessel is contained. A linear to angular motion constraining member such as a cage structure having a helical track translates linearly directed force and motion applied by the linear actuator member into a combined linear and rotational motion of the vessel. The combined vertical and rotational motion of the vessel in response to the vertical force is repeatable according to a predefined agitation pattern for mixing components in the vessel.Type: ApplicationFiled: May 16, 2018Publication date: December 6, 2018Applicant: Instrumentation Laboratory CompanyInventor: Renen Bassik
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Publication number: 20180252633Abstract: A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member made from an optically clear material and a second plate member made from an optically clear material and opposing the first plate member. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal. The floating seal surrounds a fluid chamber that retains a sample of body fluid for optical measurement. The fluid chamber may be opened for flushing by separating the first plate member from the second plate member. During measurements the fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member.Type: ApplicationFiled: May 4, 2018Publication date: September 6, 2018Applicant: Instrumentation Laboratory CompanyInventors: Brian Joseph Bosy, Josef Kerimo