Abstract: The present invention relates to enaminocarbonyl compounds with the formula I. The present invention also relates to the use of compounds with the formula I for the modification of the taste of a product and/or preparation for oral administration.
Type:
Grant
Filed:
February 2, 2010
Date of Patent:
September 30, 2014
Assignee:
Instytut Chemii Organicznej, Polska Akademia Nauk
Abstract: The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.
Type:
Grant
Filed:
September 18, 2009
Date of Patent:
September 24, 2013
Assignee:
Instytut Chemii Organicznej, Polska Akademia Nauk
Inventors:
Zofia Lipkowska, Piotr Polcyn, Andrzej Wojciech Lipkowski
Abstract: The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.
Type:
Application
Filed:
September 18, 2009
Publication date:
June 23, 2011
Applicant:
Instytut Chemii Organicznej Polska Akademia Nauk
Inventors:
Zofia Lipkowska, Piotr Polcyn, Andrzej Wojciech Lipkowski
Abstract: The invention relates to the lovastatin esterase enzyme immobilized on a solid support insoluble in water, the enzyme being covalently bound to a solid support activated with an at least difunctional coupling reagent, the immobilized lovastatin esterase exhibiting at least 5 times higher the hydrolytic activity towards lovastatin and salts thereof, in the presence of simvastatin and/or salts thereof, than towards simvastatin and salts thereof.
Type:
Application
Filed:
November 18, 2008
Publication date:
September 23, 2010
Applicant:
INSTYTUT CHEMII ORGANICZNEJ, POLSKA AKADEMIA NAUK
Inventors:
Ryszard Ostaszewski, Dominik Koszelewski, Waldemar Kurek, Dorota Patralska