Abstract: Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.
Abstract: Methods, devices, and systems for performing a plurality of isoelectric focusing reactions in parallel are described. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.
Type:
Grant
Filed:
February 24, 2020
Date of Patent:
March 29, 2022
Assignee:
Intabio, LLC
Inventors:
Erik Gentalen, Eric Gwerder, Scott Mack
Abstract: Methods, devices, and systems for performing isoelectric focusing reactions are described. The systems or devices disclosed herein may comprise fixtures that have a membrane. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.
Type:
Grant
Filed:
December 16, 2020
Date of Patent:
January 18, 2022
Assignee:
INTABIO, LLC
Inventors:
Eric Gwerder, Scott Mack, Erik Gentalen, Luc Bousse, Don Wesley Arnold