Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Type:
Grant
Filed:
July 13, 2011
Date of Patent:
November 11, 2014
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
Alice A. Jacobs, Boris Nikolic, Vineet Gupta
Abstract: Described herein are oligonucleotides useful for detecting, isolating, amplifying, quantitating, monitoring, screening and sequencing GBS genes and methods of using the described oligonucleotides.
Type:
Grant
Filed:
March 19, 2012
Date of Patent:
November 4, 2014
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
Damien Slater, Chesley Leslin, Juan Anzola, David Dolinger, Alice A. Jacobs
Abstract: Described herein are primers and probes useful for the detection, screening, isolation and sequencing of MRSA, MSSA, Staphylococci markers, MR-CoNS and the antibiotic resistance gene mecA.
Type:
Application
Filed:
March 3, 2014
Publication date:
September 11, 2014
Applicant:
Intelligent Medical Devices, Inc.
Inventors:
Heinz Reiske, Chunyang Zheng, James R . Hully, David L. Dolinger, Alice A. Jacobs, Phillip T. Moen, JR., Chesley M. Leslin, Juan Anzola, Damien Slater
Abstract: Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B, 2009 influenza A/H1N1, and a 2009 influenza A/H1N1 RNA sequence mutation associated with oseltamivir resistance.
Type:
Grant
Filed:
September 21, 2010
Date of Patent:
June 24, 2014
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
James R. Hully, David L. Dolinger, Alice A. Jacobs, Damien Slater, Heather L. B. Kiefer, Chesley Leslin, Juan Manuel Anzola
Abstract: Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza A, influenza B and RSV viruses.
Type:
Application
Filed:
October 25, 2013
Publication date:
May 8, 2014
Applicant:
Intelligent Medical Devices, Inc.
Inventors:
Sean Bradley, Paul Labrousse, Chesley Leslin, Damien Slater, James R. Hully, Alice A. Jacobs, Heather Kiefer, Juan Anzola
Abstract: Described herein are primers and probes useful for the detection, screening, isolation and sequencing of MRSA, MSSA, Staphylococci markers, and the antibiotic resistance gene mecA.
Type:
Application
Filed:
September 3, 2010
Publication date:
December 15, 2011
Applicant:
Intelligent Medical Devices, Inc.
Inventors:
Heinz R. Reiske, Chunyang Zheng, David L. Dolinger, Alice A. Jacobs, Philip T. Moen, Chesley Leslin, Juan Manuel Anzola, James R. Hully
Abstract: Described herein are primers and probes useful for detecting, screening, isolating, and sequencing of the vancomycin resistance genes and vancomycin resistant Enterococci and methods of using the described primers and probes.
Type:
Application
Filed:
September 3, 2010
Publication date:
August 18, 2011
Applicant:
INTELLIGENT MEDICAL DEVICES, INC.
Inventors:
Heinz R. Reiske, David L. Dolinger, Alice A. Jacobs, Juan Manuel Anzola
Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Type:
Grant
Filed:
November 9, 2009
Date of Patent:
August 16, 2011
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
Alice A. Jacobs, Boris Nikolic, Vineet Gupta
Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Type:
Grant
Filed:
April 8, 2005
Date of Patent:
November 24, 2009
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
Alice A. Jacobs, Vineet Gupta, Boris Nikolic
Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Type:
Grant
Filed:
March 8, 2006
Date of Patent:
July 28, 2009
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
Alice A. Jacobs, Vineet Gupta, Boris Nikolic
Abstract: The invention provides methods for designing polynucleotide primers and probes that are optimized for hybridizing to a plurality of target nucleic acid variants by employing scoring and/or ranking steps that provide a positive or negative preference or “weight” to certain nucleotides in a candidate nucleic acid sequence. The particular scoring or ranking steps performed depend upon the intended use for the primer and/or probe, the particular target sequence, and the number of variants of that target sequence. The methods of the invention provide optimal primer and probe sequences because they hybridize to more target nucleic acid variants than primers and probes in the prior art.
Type:
Application
Filed:
November 29, 2006
Publication date:
November 8, 2007
Applicant:
Intelligent Medical Devices, Inc.
Inventors:
James Hully, Gilead Kedem, Raymond Lauer
Abstract: A system and method for determining an in vivo property of a tissue or blood is described. The in vivo property may be a hematocrit value, a hemoglobin concentration, or a combination thereof. The system can automatically determine a location of a subcutaneous blood vessel. Based on the automatically determined location, the system illuminates the blood vessel with a light beam and detects light resulting from the illumination. The system determines the in vivo property based on the detected light. Alternatively, or in combination, the system displays an image corresponding to a spatial relationship between a subcutaneous blood vessel and a light beam. Based on the image, an operator can adjust the light beam with respect to the blood vessel to have a selected spatial relationship. The system determines an in vivo property based on the illumination of the blood vessel when the light beam has the selected spatial relationship.
Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Type:
Application
Filed:
March 8, 2006
Publication date:
October 26, 2006
Applicant:
Intelligent Medical Devices, Inc.
Inventors:
Alice Jacobs, Vineet Gupta, Boris Nikolic
Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
Type:
Grant
Filed:
November 27, 2001
Date of Patent:
June 14, 2005
Assignee:
Intelligent Medical Devices, Inc.
Inventors:
Alice A. Jacobs, Vineet Gupta, Boris Nikolic