Patents Assigned to Intercardia, Inc.
  • Polyamine conjugates for treatment of infection
    Patent number: 6017906
    Abstract: The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of existing anti-infective agents by the co-administration of the compounds described herein.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: January 25, 2000
    Assignee: Intercardia, Inc.
    Inventors: Clifford S. Mintz, Natan A. Kogan, Ramesh Kakarla, Helena R. Axelrod, Michael J. Sofia
  • Process for the manufacture of 3-amino-substituted glycosylated bile acids
    Patent number: 5864022
    Abstract: The present invention relates to a process for the preparation and manufacture of 3-amino-substituted glycosylated bile acid derivatives. Intermediates and related compounds are also disclosed. In particular, the present invention permits the conversion of cholic acid esters to the 3-amino-7,12-bis(glucosyl)cholic acid esters via an azide intermediate. Conditions for the purification and isolation of the desired product is also disclosed to provide an overall manufacturing process suitable for large-scale production.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: January 26, 1999
    Assignee: Intercardia, Inc.
    Inventors: Anna K. Chen, Ramesh Kakarla, Dashan Liu, Michael J. Sofia, Thomas C. Zebovitz