Abstract: A color control system for maintaining the color of a printed page of a printing press constant, within the context of the human perceptual color space system optimizes the settings of a plurality of ink keys in a printing press in accordance with a test image and a reference image. The test and reference images comprise a plurality of ink key zones corresponding to the plurality of ink keys, each ink key zone including a plurality of regions of interest (ROIs). The system includes a unit for imaging an area of the printed page in generating the reference and test images, a unit for extracting color information based on actual image colors from the test image, a unit for measuring color deviations with reference to the reference image, and a unit for analyzing and comparing global features of regions of interest (ROIs) that cover substantially the color gamut of the test image against like features of the reference image.