Patents Assigned to Intezyne Technologies, Inc.
  • PEGYLATED POLYPLEXES FOR POLYNUCLEOTIDE DELIVERY
    Publication number: 20130344117
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 26, 2013
    Applicant: INTEZYNE TECHNOLOGIES, INC
    Inventors: Janni Mirosevich, Kevin N. Sill, Gregoire Cardoen
  • Poly(ethylene glycol) containing chemically disparate endgroups
    Patent number: 8609857
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: December 17, 2013
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin Sill, Habib Skaff
  • Multi-block copolymers for the preparation of stabilized micelles
    Patent number: 8609146
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: December 17, 2013
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Habib Skaff
  • POLYMERIC MICELLES FOR POLYNUCLEOTIDE ENCAPSULATION
    Publication number: 20130266617
    Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.
    Type: Application
    Filed: August 21, 2012
    Publication date: October 10, 2013
    Applicant: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff
  • POLYMERIC MICELLES FOR DRUG DELIVERY
    Publication number: 20130195987
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
    Type: Application
    Filed: December 19, 2012
    Publication date: August 1, 2013
    Applicant: INTEZYNE TECHNOLOGIES, INC.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff, Rebecca Breitenkamp
  • POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY
    Publication number: 20130178600
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Application
    Filed: August 31, 2012
    Publication date: July 11, 2013
    Applicant: INTEZYNE TECHNOLOGIES, INC.
    Inventor: Kevin Sill
  • Compositions comprising polymeric micelles for drug delivery
    Patent number: 8299128
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: October 30, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Habib Skaff, Kurt Breitenkamp, Rebecca Breitenkamp
  • Polymeric micelles for polynucleotide encapsulation
    Patent number: 8287910
    Abstract: The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: October 16, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Gregoire Cardoen, Kevin N. Sill, Habib Skaff
  • Synthesis of hybrid block copolymers and uses thereof
    Patent number: 8268936
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: September 18, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill
  • Azide functionalized peptide targeting groups
    Patent number: 8263663
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: September 11, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Habib Skaff, Kurt Breitenkamp, Rebecca Breitenkamp
  • Polymeric micelles for drug delivery
    Patent number: 8263665
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: September 11, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Habib Skaff, Kurt Breitenkamp, Rebecca Breitenkamp
  • POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS
    Publication number: 20120226050
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Application
    Filed: May 14, 2012
    Publication date: September 6, 2012
    Applicant: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
  • Encapsulated contrast agents
    Patent number: 8258190
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: September 4, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Habib Skaff, Kurt Breitenkamp, Kevin N. Sill
  • Heterobifunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
    Patent number: 8212083
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: July 3, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff
  • Poly(ethylene glycol) containing chemically disparate endgroups
    Patent number: 8207353
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: June 26, 2012
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin N. Sill, Habib Skaff, Kurt Breitenkamp
  • Covalent modification of metal surfaces
    Patent number: 8066824
    Abstract: The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: November 29, 2011
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Rebecca Breitenkamp, Kevin N. Sill, Habib Skaff
  • CONTROLLED POLYPLEX ASSEMBLY
    Publication number: 20110256227
    Abstract: The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, polyplexes comprising polycations, polyanions, and polynucleotides are provided. The invention further provides methods of making and using said polyplexes.
    Type: Application
    Filed: April 14, 2011
    Publication date: October 20, 2011
    Applicant: Intezyne Technologies, Inc.
    Inventors: Janni Mirosevich, Kevin N. Sill
  • POLY(ETHYLENE GLYCOL) DERIVATIVES FOR METAL-FREE CLICK CHEMISTRY
    Publication number: 20110224383
    Abstract: The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.
    Type: Application
    Filed: March 11, 2011
    Publication date: September 15, 2011
    Applicant: INTEZYNE TECHNOLOGIES, INC.
    Inventors: Kevin N. Sill, Gregoire Cardoen
  • AZIDE FUNCTIONALIZED PEPTIDE TARGETING GROUPS
    Publication number: 20110092668
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
    Type: Application
    Filed: December 7, 2010
    Publication date: April 21, 2011
    Applicant: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff, Rebecca Breitenkamp
  • COMPOSITIONS COMPRISING POLYMERIC MICELLES FOR DRUG DELIVERY
    Publication number: 20110091534
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
    Type: Application
    Filed: December 7, 2010
    Publication date: April 21, 2011
    Applicant: Intezyne Technologies, Inc.
    Inventors: Kurt Breitenkamp, Kevin N. Sill, Habib Skaff, Rebecca Breitenkamp