Abstract: An analgesic and a delivery agent are combined in a pharmaceutical composition such that, on introduction into the nasal cavity of a patient to be treated, the analgesic may be delivered to the bloodstream to produce within 30 minutes a therapeutic plasma concentration, Cther, of 0.2 ng/ml or greater which is maintained for a duration Tmaint of at least 2 hours. The analgesic may be an opioid analgesic or a non-steroidal anti-inflammatory drug.
Type:
Application
Filed:
May 14, 2007
Publication date:
October 4, 2007
Applicants:
IONIX PHARMACEUTICALS LIMITED, ARCHIMEDES DEVELOPMENT LIMITED
Inventors:
Phillip Birch, Ann Hayes, Peter Watts, Jonathan Castile
Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.
Type:
Grant
Filed:
July 26, 2002
Date of Patent:
September 26, 2006
Assignee:
Ionix Pharmaceuticals Limited
Inventors:
John Nicholas Wood, Armen Norakovitch Akopian
Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.
Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.
Type:
Application
Filed:
July 26, 2002
Publication date:
September 18, 2003
Applicant:
IONIX PHARMACEUTICALS LIMITED
Inventors:
John Nicholas Wood, Armen Norakovitch Akopian
Abstract: The present invention relates to a novel 1,957 amino acid tetrodotoxin-insensitive voltage-gated sodium channel specifically located in mammalian sensory neurons. Nucleic acid sequences coding for the novel sodium channel, vectors, host cells and methods of identifying modulators of the novel sodium channel for use in treatment of pain are also provided.
Type:
Grant
Filed:
June 24, 1996
Date of Patent:
September 17, 2002
Assignee:
Ionix Pharmaceuticals Limited
Inventors:
John Nicholas Wood, Armen Norakovitch Akopian