Patents Assigned to IRIS International, Inc.
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Patent number: 10060846Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Parrticles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: GrantFiled: July 10, 2017Date of Patent: August 28, 2018Assignee: Iris International, Inc.Inventors: Bart J. Wanders, Gregory A. Farrell, Thomas H. Adams, Warren Groner, Xiaodong Zhao, Brett Jordan, Jack Cremins, Carol Quon
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Publication number: 20180149576Abstract: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer. In one aspect, this disclosure relates to a particle imaging system comprising a flowcell through which a sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis of samples. Other compositions, methods and features of this disclosure are disclosed herein.Type: ApplicationFiled: January 25, 2018Publication date: May 31, 2018Applicant: Iris International, Inc.Inventors: Bart J. Wanders, Thomas H. Adams, Gregory A. Farrell, Warren Groner, Xiaodong Zhao
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Publication number: 20180143182Abstract: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.Type: ApplicationFiled: November 21, 2017Publication date: May 24, 2018Applicant: Iris International, Inc.Inventors: Bart J. Wanders, Eric Chapoulaud, Brett Jordan
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Patent number: 9939356Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents and one or more permeabilizing agents, optionally including one or more fixing agents and other components. The particle contrast agent composition can include Crystal Violet, 5PD-Lytic, and Proclin 300.Type: GrantFiled: April 25, 2016Date of Patent: April 10, 2018Assignee: Iris International, Inc.Inventor: Jack Cremins
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Patent number: 9910037Abstract: The present disclosure relates to compositions, methods, and kits for the rapid detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using vancomycin—PVA backbone complexes to capture and/or concentrate microorganisms in an aqueous sample, such as gram positive and/or gram negative bacteria in solution.Type: GrantFiled: March 13, 2014Date of Patent: March 6, 2018Assignee: Iris International, Inc.Inventors: Edward Jablonski, Carl Hulle
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Patent number: 9909973Abstract: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer. In one aspect, this disclosure relates to a particle imaging system comprising a flowcell through which a sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis of samples. Other compositions, methods and features of this disclosure are disclosed herein.Type: GrantFiled: February 19, 2016Date of Patent: March 6, 2018Assignee: Iris International, Inc.Inventors: Bart J. Wanders, Thomas H. Adams, Gregory A. Farrell, Warren Groner, Xiaodong Zhao
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Patent number: 9857361Abstract: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis. A contrast pattern for autofocusing is provided on the flowcell. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Cell or particle images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.Type: GrantFiled: March 17, 2014Date of Patent: January 2, 2018Assignee: IRIS International, Inc.Inventors: Bart J. Wanders, Eric Chapoulaud, Brett Jordan
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Publication number: 20170370820Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Parrticles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: ApplicationFiled: July 10, 2017Publication date: December 28, 2017Applicant: Iris International, Inc.Inventors: Bart J. Wanders, Gregory A. Farrell, Thomas H. Adams, Warren Groner, Xiaodong Zhao, Brett Jordan, Jack Cremins, Carol Quon
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Patent number: 9766237Abstract: The present disclosure relates to compositions, methods, and kits for the detection, separation and/or isolation of microorganisms. Specifically, the disclosure relates to compositions, methods, and kits for using polylysine-coated particles to capture microorganisms such as bacteria.Type: GrantFiled: March 13, 2014Date of Patent: September 19, 2017Assignee: Iris International, Inc.Inventors: Edward Jablonski, Carl Hulle
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Patent number: 9746412Abstract: The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel.Type: GrantFiled: November 26, 2014Date of Patent: August 29, 2017Assignee: Iris International, Inc.Inventor: Yong Qin Chen
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Patent number: 9702806Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: GrantFiled: March 18, 2014Date of Patent: July 11, 2017Assignee: Iris International, Inc.Inventors: Bart J. Wanders, Gregory A. Farrell, Thomas H. Adams, Warren Groner, Xiaodong Zhao, Brett Jordan, Jack Cremins, Carol Quon
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Publication number: 20170076054Abstract: In some embodiments, a method is provided for returning medical data comprising a test result from a particle analyzer including receiving a clinical data query in an initial format from an input object. After receiving the clinical data query, transforming the clinical data query into multiple different query types, each different query type having a different format from the initial format, each different query type for querying a different medical database or object graph in memory. Querying the medical databases using one of the query types based on the medical database. In response to the querying, receiving the data sets from the medical databases including the test result from the particle analyzer. Once data sets are received, output at least some information from the data sets.Type: ApplicationFiled: August 17, 2016Publication date: March 16, 2017Applicant: IRIS International, Inc.Inventors: Jon F. Tindel, Jun Yang
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Publication number: 20170038291Abstract: The disclosed flow cytometer includes a wavelength division multiplexer (WDM). The WDM includes an extended light source providing light that forms an object, a collimating optical element that captures light from the extended light source and projects a magnified image of the object as a first light beam, and a first focusing optical element configured to focus the first light beam to a size smaller than the object of the extended light source to a first semiconductor detector. The disclosed flow cytometer further includes a composite microscope objective to direct light emitted by a particle in a flow channel in a viewing zone of the composite microscope to the extended light source, a fluidic system and a peristaltic pump configured to supply liquid sheath and liquid sample to the flow channel, and a laser diode system to illuminate the particle in the flow channel.Type: ApplicationFiled: October 21, 2016Publication date: February 9, 2017Applicant: IRIS INTERNATIONAL, INC.Inventor: Yong Qin Chen
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Patent number: 9470618Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.Type: GrantFiled: March 8, 2016Date of Patent: October 18, 2016Assignee: IRIS International, Inc.Inventors: Gregory A. Farrell, Bart J. Wanders, Thomas H. Adams, Warren Groner, Xiaodong Zhao
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Patent number: 9429524Abstract: Systems and methods for imaging a plurality of blood fluid samples or other types of samples include processing at least a portion of a sample to enhance imageability of certain particles in that portion and subsequently imaging the sample portion. In some instances, processing and imaging of various samples may be staged in a manner to optimize throughput of the system or method.Type: GrantFiled: October 17, 2014Date of Patent: August 30, 2016Assignee: Iris International, Inc.Inventor: Bart J. Wanders
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Patent number: 9322752Abstract: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer. In one aspect, this disclosure relates to a particle imaging system comprising a flowcell through which a sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis of samples. Other compositions, methods and features of this disclosure are disclosed herein.Type: GrantFiled: March 17, 2014Date of Patent: April 26, 2016Assignee: IRIS International, Inc.Inventors: Bart J. Wanders, Thomas H. Adams, Gregory A. Farrell, Warren Groner, Xiaodong Zhao
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Patent number: 9322753Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents and one or more permeabilizing agents, optionally including one or more fixing agents and other components. The particle contrast agent composition can include Crystal Violet, 5PD-Lytic, and Proclin 300.Type: GrantFiled: March 17, 2014Date of Patent: April 26, 2016Assignee: IRIS International, Inc.Inventor: Jack Cremins
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Patent number: 9316635Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.Type: GrantFiled: March 17, 2014Date of Patent: April 19, 2016Assignee: IRIS International, Inc.Inventors: Gregory A. Farrell, Bart J. Wanders, Thomas H. Adams, Warren Groner, Xiaodong Zhao
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Patent number: 9279750Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Crystal Violet, New Methylene Blue, Saponin, and Gluteraldehyde.Type: GrantFiled: March 17, 2014Date of Patent: March 8, 2016Assignee: Iris International, Inc.Inventors: Jack Cremins, Carol Quon
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Patent number: 9234890Abstract: The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogenous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention and for performing the methods of the invention are also provided.Type: GrantFiled: May 27, 2011Date of Patent: January 12, 2016Assignee: Iris International, Inc.Inventors: Thomas Adams, Edward Jablonski