Abstract: New derivatives of theophylline are described, which have the general formula: ##STR1## in which R is selected from the group consisting of 2'-(1'-oxy-1', 3'-dithiolanyl), 2'-(1', 3'-dithiolanyl) and 2'-(1',3'-dithianyl), possibly substituted in position 4'. The derivatives have high antibronchospastic, antitussive and mucolytic activities.
Abstract: A new compound of the general formula I: ##STR1## obtained from the ursodeoxycholic acid, soluble in water and its pharmaceutical compositions.
Abstract: Compounds of the following general formula ##STR1## wherein: X and Y are different from each other and represent --CH.sub.2 -- or an oxygen atom; R represents a radical selected from hydroxy, bromo, acetoxy, pyrrolidino, morpholino, piperazino and piperazino substituted at the position 4 by a carbethoxy, benzyl, phenyl, halophenyl, methoxyphenyl or trifluoromethylphenyl group, or when X is --CH.sub.2 -- and Y is an oxygen atom, R may represent also chloro; methods for their preparation; pharmaceutical compositions containing them. The compounds possess a remarkable antitussive activity.
Abstract: Pharmaceutical compositions are described which exhibit anti-ulcer activity. They contain as the active ingredient an effective amount of 5-methoxy-2-methyl-3-indolylacetohydroxamic acid of formula I ##STR1## The compositions are suitable for oral administration. The compositions are particularly useful for treatment of ulcers caused by other pharmaceuticals such as pharmaceuticals of the steroid type, but not limited to pharmaceuticals of the steroid type.
Abstract: A pharmaceutical composition with anti-bronchospasmodic and anti-tussive activity which contains an effective amount of the compound of formula ##STR1## together with at least one pharmaceutically acceptable carrier or diluent. The composition may be administered orally, parenterally, rectally or by means of an aerosol.
Abstract: A process for the preparation of indole-3-acetohydroxamic acids having the formula: ##STR1## wherein R is a hydrogen atom or a p-chlorobenzoyl, benzyl or an allyl radical, in which the corresponding 2-methyl-5-methoxyindole-3-acetaldehyde is reacted with benzenesulfohydroxylamine in the presence of aqueous sodium hydroxide at from 0.degree. C. to 4.degree. C. at a pH less than 8, to form the sodium salt of the required acid. The required acid is liberated by the addition of hydrochloric acid and precipitated by the addition of water. The required acid in which R is a hydrogen atom may alternatively be prepared by debenzoylation of the acid in which R is the p-chlorobenzoyl radical.