Patents Assigned to Istituto Farmacologico Serono, S.P.A.
  • Genetic expression of somatostatin as hybrid polypeptide
    Patent number: 5268278
    Abstract: New plasmid vectors are described, containing the entire Trp regulatory system including promoter, operator, leader and attenuator, and methods for the expression of hybrid polypeptides in E. coli The hybrid polypeptides can contain the heterologous sequence of somatostatin.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: December 7, 1993
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventors: Umberto Canosi, Gabriele De Fazio, Stefano Villa, Silva Donini
  • Mixtures of FSH and LH from pig hypophyses in a definite ratio
    Patent number: 4959354
    Abstract: The mixturex of FSH ( follicle stimulating hormone) and LH ( luteinizing horomone) being extracted from pig hypophyses in a definite ratio, improve to an optimum level the induction of super-ovulation in bred animals.
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: September 25, 1990
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventor: Manlio Barbetti
  • Treatment of parasitic diseases with calf thymus extract
    Patent number: 4772588
    Abstract: A course of a parasitic, e.g. protozoal, infection is combated by administering to the host an immunomodulating effective amount of a calf thymus hormone extract.
    Type: Grant
    Filed: April 29, 1986
    Date of Patent: September 20, 1988
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventor: Giovanna Scioppacassi
  • Pharmaceutical composition containing a fibrinolytic agent and a diffusion factor, useful for the treatment of myocardial infarction
    Patent number: 4568543
    Abstract: The association of a fibrinolytic agent and of a diffusion factor has been shown very useful in the treatment of myocardial infarction. It has been shown that it is very useful to administer urokinase and hyaluronidase in the quantity ratio of at least 8 to 1, the quantity of each compound being expressed in the appropriate international units.
    Type: Grant
    Filed: November 8, 1984
    Date of Patent: February 4, 1986
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventors: Francesco Borrelli, Francesco Antonetti
  • Process for the extemporaneous preparation of liposomes
    Patent number: 4308166
    Abstract: The extemperaneous preparation of liposomes incorporating englobed therapeutically active substances is effected by introducing an aspirated phopholipid emulsion into a container containing the active substance as a dry powder or lyophilate.
    Type: Grant
    Filed: October 30, 1979
    Date of Patent: December 29, 1981
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventors: Enzo Marchetti, Umberto Bucciarelli
  • Radioimmunoassay method for human chorionic gonadotropin in the presence of luteinizing hormone
    Patent number: 3992514
    Abstract: A highly specific antiserum with respect to human chorionic gonadotropin (HCG) is prepared by absorbing anti-HCG-.beta.-subunit serum with HCG-.alpha.-subunit. Such antiserum is suitable for use in radioimmunoassay of HCG in the presence of luteinizing hormone.
    Type: Grant
    Filed: October 25, 1974
    Date of Patent: November 16, 1976
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventor: Pietro Donini
  • Process for preparing synthetic L-pyroglutamyl-L-histidyl-L-prolinamide
    Patent number: 3966700
    Abstract: Highly pure pyroglutamyl-histidyl-prolinamide is prepared by removing the protecting groups of the protected tripeptide by means of reductive deprotection with sodium in liquid ammonia followed by passing the crude deprotected tripeptide through a gel filtration means.
    Type: Grant
    Filed: September 27, 1974
    Date of Patent: June 29, 1976
    Assignee: Istituto Farmacologico Serono, S.P.A.
    Inventor: Gabriele Mattalia
  • Treatment of heart diseases
    Patent number: 3966915
    Abstract: Phosvitin, a phosphoprotein extracted from hen's egg yolk, has been found effective in the treatment of such heart diseases as myocardial diseases, coronary heart diseases and heart failure.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: June 29, 1976
    Assignee: Istituto Farmacologico Serono S.p.A.
    Inventor: Luciano Caprino