Abstract: Dermatological and cosmetic compositions having high endermicity and antiageing activity and high stability are herein described consisting of: 1) emulsifying and self-emulsifying agents, having o/w activity formed by a mixture containing (as % w/w); 1') polyethylene glycol mono- or distearate 0.5-5.0%; 2') polyglycol esters of saturated or unsaturated C.sub.14 -C.sub.20 fatty acids 1.0-10.0%; 3') cetyl alcohol and optionally other higher alcohols, comprising free or esterified sterols 1.0'16.0%; 2) sodium versenate and antioxidant agents 0.1-5.0%; 3) anti-mould and bacteriostatic agents 0.05-0.1%; 4) active ingredients 1-30%; 5) purified water F.U. q.s. to 100%.

Abstract: Compounds of formula (I) ##STR1## in which A is (CH.sub.2).sub.n in which n is 1-10, preferably 3 or 5, and R is the acyl group from a known anti-inflammatory agent, exhibit high anti-inflammatory activity. The mechanism of action is novel because they do not release the anti-inflammatory agent in the body but exhibit an activity superior to the activity of the known anti-inflammatory agent. The compounds are also active in combating bone calcium loss.

Abstract: The present invention concerns a compound of formula (I) ##STR1## wherein: X is selected from H and OH;R is a residue which, linked to the ##STR2## group, forms an amino acid; the enantiomers and racemic mixtures thereof; and the pharmaceutically acceptable salts thereof.The invention further concerns a pharmaceutical composition which comprises the above compound or salts thereof and the use of the compound for treating an articular pathology.

Abstract: 4,5-Dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid dicarbonates and urethanes having therapeutic activities, a process for the preparation thereof and pharmaceutical compositions containing them.

Abstract: This application describes 3-arylalkyl esters of 4,5-dihydro-9,10-dioxo-2-anthracenecarboxylic acid and a process for making them. Also described is a method of using the compounds in the treatment of arthritis.

Abstract: A process for the preparation of undenaturated triple helix collagen, starting form animal tendons or cutis, by extraction with diluted organic acids, precipitation with salts, optional gelation and/or lyophilization, tangential filtration.The obtained collagen shows favorable purity characteristics, is not allergenic and more effective in the healing processes than collagens obtained by known methods.

Abstract: This invention relates to pharmaceutical compositions for the treatment of arthrosis by intraarticular administration of the compositions diluted in a suitable aqueous or lyophilized carrier, comprising an effective amount of diphosphonates and amino acids, specifically aminocarboxylic acids, added thereto as stabilizers. The invention also relates to a therapeutic method for the treatment of arthrosis by intraarticular administration of the compositions into the body of human beings and animals.

Abstract: A method for the preparation of tablets slowly releasing the active principle, characterized in that (I) during the granulation step a solution in organic solvents of a polymer insoluble in biological juices is sprayed on a mixture containing an active principle, slightly swelling polymers and usual excipients; (II) the granulated obtained in this way is added with a highly hydroswelling colloidal polymer; (III) a solution, in organic solvents, of an entero-soluble polymer, is sprayed on the granulate; (IV) the resulting granulate is submitted to compression; (V) the obtained tablets are hardened by washing with organic solvents; and (VI) they are then optionally coated.

Abstract: Hydrosoluble pharmaceutical compositions containing, as the active principal, salts of (-)cis-1,2-epoxypropylphosphonic acid with aminoacids such as arginine, ornithine, lysine, cysteine, and the like, characterized by containing a hydrophyllic organic base.

Abstract: The invention concerns a process for the preparation of diphosphonic acids starting from carboxylic acids, a phosphorus trihalide and orthophosphorous acid, without solvents, using particular molar ratios and conditions so as to keep the reaction mixture fluid and carrying out the hydrolysis only with boiling water.

Abstract: Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl.sub.2 MDP.

Abstract: A pharmaceutical composition for the treatment of osteopathias is described which contains an effective amount of the active ingredient 6-amino-1-hydroxyhexane-1,1-diphosphonic acid or a pharmaceutically acceptable salt, ester, or a chelation complex with copper and inert carriers. The compositions are suitable for oral or systemic administration or topical application.