Abstract: An aerosol generating device which is capable of generating an aerosol at an appropriate timing includes: a power source which supplies power in order to atomize an aerosol source and/or heat a flavor source; a sensor which outputs a measurement value for controlling the power supplied; and a controller which controls the power supplied on the basis of the measurement value. The controller controls a power supply amount from the power source to be a first value when the measured value is equal to or larger than a first threshold and smaller than a second threshold larger than the first threshold, and the power supply amount to be larger than the first value when the measured value is equal to or larger than the second threshold.

Abstract: Control device for aerosol inhalation device, includes operational amplifier including output terminal configured to generate voltage according to voltage applied to load configured to heat aerosol source and having correlation between temperature and electrical resistance value, control unit including input terminal and configured to perform processing based on voltage applied to the input terminal, and voltage dividing circuit configured to electrically connect the output terminal of the operational amplifier and the input terminal of the control unit. Power supply voltage of the operational amplifier is higher than power supply voltage of the control unit, and equals voltage applied to aerosol generation circuit including the load, and one of inverting input terminal and noninverting input terminal of the operational amplifier is electrically connected to the aerosol generation circuit.

Abstract: A power supply unit of an aerosol generation apparatus includes: a power supply capable of discharging to a load for generating an aerosol from an aerosol source; a controller configured to control the power supply; and a housing configured to house the power supply and the controller. The controller is configured to detect at least one of leakage of a liquid inside the housing and entering of a liquid into the housing.

Abstract: An oral tobacco product (1) has a pouch (2) made of a nonwoven fabric, a tobacco mixture containing tobacco particles made from tobacco materials as a major ingredient, enclosed in the pouch (2), and a water-repellent area (30) formed on an inner surface of the pouch (2) to account for 50% of the entire inner surface of the pouch, the water-repellent area preventing permeation of water.

Abstract: A gene silencing vector according to the present invention comprises a vector which includes a promoter, an enhancer sequence in the downstream of the promoter, and a gene encoding a potyvirus-origin coat protein in the downstream of the enhancer sequence, wherein in order to cause gene silencing of the specific target gene in a host plant, the vector is used with a specific target gene or a gene that is homologous to the target gene inserted in the vicinity of the gene encoding the coat protein.

Abstract: The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof.

Abstract: The present invention relates to a compound of the formula [1?] ? wherein R2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, —O—, —S— and the like, ring G is aryl, heterocyclic group and the like, R5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1?] as an active ingredient. The compound [1?] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1?] as a nociceptin antagonist or analgesic.

Abstract: The object of the present invention is to screen and identify a novel antimicrobial protein which can inhibit the growth of plant pathogenic microorganisms at a relatively low concentration such as Pyricularia oryzae and Rhizoctonia solani causative of two major diseases causing damage to rice crops and, further, to clone the gene of this protein. According to the present invention, an antimicrobial protein which can be obtained from a fraction of an aqueous extract of Lyophyllum shimeji precipitated by the ammonium sulfate precipitation method, has an antimicrobial activity at least against Rhizoctonia solani or Pyricularia oryzae, and shows the presence of components of about 70 kDa and/or about 65 kDa in molecular weight in the SDS-PAGE method. A gene encoding this protein and a method of using the same are provided.

Abstract: A goods arrangement system includes a goods storage arrangement apparatus 7000 capable of storing goods temporarily and discharging a specified number of goods at the same time. The goods storage arrangement apparatus 7000 consists of a gradient storage shelf 7774 made up of multiple gravity roller conveyors 7001, and arrangement conveyors 7002 associated with the stories of gravity roller conveyors. Unpackers 1000 and 2000 peel off outer flaps from each box (container) containing goods, and a flap opener 4000 opens up and down outer flaps on one of the sides of a box. A goods takeout apparatus 5000 takes out goods from a box. The taken-out goods are fed to the goods storage arrangement apparatus 7000 by a goods feeder 6000 based on a running cart 6034. In the goods storage arrangement apparatus 7000, the arrangement conveyors 6002 arrange multiple goods in a row substantially perpendicularly to the direction in which the arrangement conveyors run.

Abstract: A gene encoding an enzyme aqualysin I is disclosed. The gene of the present invention comprises a region encoding a signal peptide; a pro-region located downstream the signal peptide-encoding region; a region encoding aqualysin I, which is located downstream the pro-region; and a tail region of aqualysin I, which is located downstream the aqualysin I-encoding region. This invention also provides a recombinant vector comprising the gene, Escherichia coli transformed with the recombinant vector and a process of producing aqualysin I utilizing the Escherichia coli.

Abstract: A method of preparing (S)-.gamma.-hydroxymethyl-.alpha.,.beta.-butenolide includes the step of oxidizing a levoglucosenone with a peracid in an organic solvent. Peracetic acid, metha-chloroperbenzoic acid or magnesium monoperoxyphthalate hexahydrate can be used as the peracid. According to this method, an (S)-.gamma.-hydroxymethyl-.alpha.,.beta.-butenolide having high optical purity can be easily prepared from a levoglucosenone as a starting material at a high yield.