Abstract: The present invention relates to a method, a program, and a system for determining a formulation of a combination consisting of multiple candidate substrates of smell, taste, or somatic sensation and reproducing a smell, taste, or somatic sensation of a target substance, and a method for producing a mixture that reproduces a smell, taste, or somatic sensation of a target substance, from a combination consisting of multiple candidate substrates of smell, taste, or somatic sensation.

Abstract: A filtered smoking article includes a smoking body, a filter including a filter member and an air-permeable paper, and having a flavor capsule arranged therein, and a tipping paper. The flavor capsule includes a capsule body, and a colored content liquid containing a flavor component. The air-permeable paper is arranged to be opposed to a region in which the colored content liquid is released when the flavor capsule is crushed, and has an air permeability of 1,000 C.U. to 30,000 C.U. The tipping paper is impermeable to the colored content liquid, and includes at least three transparent parts. Each of the transparent parts is arranged to be opposed to the region in which the colored content liquid is released.

Abstract: Provided is a battery unit including: a power supply; a detector configured to detect an output voltage of the power supply; a connecting configured to be connectable with a load for atomizing an aerosol source or heating a flavor source; and a controller capable of executing a power supply mode in which electric power is supplied to the load from the power supply. The controller executes a specific control different from the supply of electric power to the load based on am amount of change in the output voltage per a predetermined time period in the power supply mode.

Abstract: A filtered smoking article includes an aerosol generation rod, a filter disposed at a downstream end of the aerosol generation rod, and tipping paper wrapped around a downstream end part of the aerosol generation rod and an outer circumferential surface of the filter and connecting the aerosol generation rod and the filter. The tipping paper is paper containing bleached pulp and unbleached pulp, and fibers of the unbleached pulp have a length of 1 mm to 4 mm and a thickness of 20 ?m to 70 ?m.

Abstract: An inhalation component generating device includes: a power supply; a load group including a load configured to evaporate or atomize an inhalation component source by power from the power supply; and a control circuit configured to be able to acquire a voltage value of the power supply. The control circuit performs: a process (al) of acquiring a closed circuit voltage value of the power supply in a closed circuit state in which the power supply and the load group are electrically connected; and a process (a2) of comparing the acquired closed circuit voltage value and a first reference voltage value, and determining that the power supply is in a small residual amount state in a case where the closed circuit voltage value is smaller than or is equal to or smaller than the reference voltage value.

Abstract: A flavor inhaler includes a heating element that atomizes an aerosol source and a supply member that has a discharge port for supplying the aerosol source to the heating element. The heating element has a porous structure, and is disposed apart from the discharge port.

Abstract: A battery unit for a favor inhaler includes a chargeable and dischargeable power supply, a connection part capable of electrically connecting to an external charger, and a controller configured to perform control regarding at least the power supply, wherein when an accumulated value of a connection time period to the charger exceeds a first predetermined time period, the controller determines that the power supply has been degraded.

Abstract: A power supply unit for an aerosol inhaler includes: a power supply able to discharge power to a load for generating an aerosol from an aerosol source; a connector able to be electrically connected to an external power supply; a control device configured to control at least one of charging and discharging of the power supply or configured to be able to convert power which is input from the connector into charging power for the power supply; and a zener diode provided between the connector and the control device so as to be connected in parallel with the control device. A maximum value of zener voltage of the zener diode is lower than a maximum operation guarantee voltage of the control device.

Abstract: To provide a control device for an aerosol inhalator capable of compensating changes in temperature of a heater due to inhalation. A control device for an aerosol inhalator includes a first sensor for obtaining a first value relating to a temperature of a load which atomizes an aerosol source stored in a reservoir or retained by an aerosol base using heat generated by supply of electric power, a second sensor configured to detect an inhalation, and a controller, wherein the controller is configured to determine, based on a second value based on the first value and a threshold, whether the aerosol source in the reservoir or the aerosol base is depleted or insufficient (850A), and correct at least one of the second value and the threshold when detecting the inhalation (840) and, in the determination, compare the second value and the threshold, at least one of the second value and the threshold being corrected (842).

Abstract: A heater assembly includes a container including a cylindrical portion that forms a chamber in which a flavor generating article is contained, and a heater arranged in a peripheral surface of the cylindrical portion. The container includes a first channel extending along a longitudinal direction of the cylindrical portion and located adjacently to the chamber in a direction intersecting with the longitudinal direction of the cylindrical portion, and a second channel extending through the chamber along the longitudinal direction of the cylindrical portion. The first channel is in communication with the second channel.

Abstract: A flavor generating segment includes a first flavor generating member and a second flavor generating member, wherein: at least either of the first and the second flavor generating members includes a plurality of stacked flavor generating sheets and has, between at least a pair of the neighboring flavor generating sheets, a non-contact part in which the flavor generating sheets do not come into contact with each other; and principal surfaces of the flavor generating sheets face the other flavor generating member, as well as a flavor generating article and a flavor inhalation system equipped therewith. The flavor generating segment gives a good smoking flavor.

Abstract: A circuit board for a non-combustion flavor inhaler includes a substrate and an electrically conductive ink pattern printed on the substrate. The substrate includes paper. A percentage weight loss of the paper from room temperature to 290° C. is less than 20% of a percentage weight loss of the paper from room temperature to 900° C. under a condition that allows air to flow at a flow rate of 100 mL/min while elevating a temperature of the air at a speed of 10° C./min.

Abstract: An anti-HIV agent containing, as an active ingredient, ex, 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.

Abstract: A heater assembly comprises a container including a cylindrical portion that forms a chamber in which a flavor generating article is contained, and a heater arranged in a peripheral surface of the cylindrical portion. The container includes a first channel extending along a longitudinal direction of the cylindrical portion and located adjacently to the chamber in a direction intersecting with the longitudinal direction of the cylindrical portion, and a second channel extending through the chamber along the longitudinal direction of the cylindrical portion. The first channel is in communication with the second channel.

Abstract: A power supply unit includes: a power supply configured to discharge power to a load for generating an aerosol from an aerosol generation source; a charger configured to convert inputted power into charging power; a temperature measuring unit configured to measure a temperature of the power supply; and a charging controller configured to perform a first control for stopping the charger from supplying the charging power to the power supply and a second control for causing the charger to supply the charging power to the power supply, the charging controller setting a duty ratio to a value greater than 0 and smaller than 100 in a case where the temperature of the power supply is within a predetermined range, and the duty ratio being obtained by dividing a time during which the charging controller performs the first control by a unit time.

Abstract: The present invention provides processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives, which are useful as a Janus kinase (JAK) inhibitor, intermediates thereof, and processes for preparing the intermediates. The present invention provides processes for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile using salts of (3S,4R)-1-benzyl-3-methyl-1,6-diazaspiro[3.4]octane with organic acids.

Abstract: In order to provide tobacco resistant to a virus, tobacco in accordance with the present invention is arranged such that: (i) a translation initiation factor eIF(iso)4E protein which is non-functional with respect to a virus is produced or (ii) expression of a translation initiation factor eIF(iso)4E gene is suppressed; and (a) a translation initiation factor eIF4E2 protein, which is non-functional with respect to a virus, is produced or (b) expression of a translation initiation factor eIF4E2 gene is suppressed.

Abstract: A power supply unit for an aerosol inhaler includes: a power supply able to discharge power to a load for generating an aerosol from an aerosol generation source; and a charger including an information input part, and configured to be able to supply one of a first charging voltage and a second charging voltage lower than the first charging voltage to the power supply, based on an input value which is input from the information input part. A fixed value which is predetermined as one input value can be input to the information input part, and the fixed value is a value for supplying the second charging voltage to the power supply.

Abstract: A smoking system includes a consumable containing a smokable substance and a device that includes a chamber receiving the consumable and heats and atomizes the smokable substance of the consumable received in the chamber. The chamber includes an opening through which the consumable is inserted and a holding unit that holds the consumable. The holding unit includes a first pressing unit which presses a part of the consumable. The consumable includes a first portion having a first hardness and a second portion having a second hardness, in which the second portion is a different portion from the first portion in the insertion direction of the consumable. When the consumable is positioned at the desired position in the chamber, the consumable is positioned such that at least a part of the first portion is pressed against the first pressing unit, while at the same time, at least a part of the second portion is pressed against the first pressing unit.

Abstract: The present invention provides a compound having a Pim-1 inhibitory activity. The present invention provides a compound of Formula [I] or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a pharmaceutical use thereof, and the like. wherein each symbol is as defined in the description.