Abstract: A long-acting super-hydrophobic anticoagulant biological valve and a preparation method therefor. The preparation method includes the following steps: (1) treating a biological valve material with glutaraldehyde; (2) placing the biological valve material treated in step (1) into an acid liquid containing a polyphenol compound and metal ions, and adding an oxidant for reaction; and (3) reacting the biological valve material treated in step (2) with a hydrophobic substance. According to the method, a super-hydrophobic coating having a long-acting high water contact angle and a low rolling angle is prepared on the surface of the biological valve by means of a simple and stable operation process without affecting the performance of the valve body, and the requirements of long-acting anticoagulation are met by resisting the adsorption of plasma proteins.

Abstract: The present invention provides a valve material having synergistic anti-coagulation and anti-calcification functions and a preparation method therefor. The preparation method comprises the following steps: performing glutaraldehyde cross-linking treatment on an animal-derived biological valve material; immersing the treated valve material in a blocking solution containing an amine compound for 0.5-6 h, thereby blocking the remaining aldehyde groups after glutaraldehyde cross-linking; then placing the valve material into a reaction solution containing an anticoagulant and a cross-linking agent, and performing cross-linking treatment for 6-24 h at 4° C.-37° C.; and finally washing and obtaining the valve material, and storing the valve material in a mixed solvent of glutaraldehyde or isopropyl alcohol/glycerol. The method can effectively solve the problem of calcification and thrombosis caused by residual aldehyde groups in a valve material prepared by the existing method.