Abstract: The present invention provides nucleic acid molecules which include a region specifically interacting with the nucleic acid encoding the LEDGF/P75 protein or the nucleic acid encoding a fragment of a LEDGF/P75 protein and methods and uses of such nucleic acid molecules.
Type:
Grant
Filed:
February 25, 2009
Date of Patent:
August 30, 2011
Assignee:
K.U. Leuven Research & Development
Inventors:
Zeger Debyser, Petr Cherepanov, Erik De Clercq
Abstract: The present invention relates generally to a method and device of partial or complete functional restoration of the damaged nervous system by bridging a cavity in the central or peripheral nervous tissue and, more particularly to a system and method for repairing the nerve signal transduction by bridging of the cavity with microelectrode elements more particular microelectrodes for stimulation and microelectrodes for recording.
Type:
Grant
Filed:
July 3, 2006
Date of Patent:
August 2, 2011
Assignees:
K.U.Leuven Research & Development, IMEC
Inventors:
Carmen Bartic, Jean-Pierre Kruth, Bart Nuttin
Abstract: The present invention relates, in general, to sheet material forming technology and the forming of structures there from. The invention relates to incremental forming of sheet material (1) with localised heating (5) and more particularly to a system and method for incrementally forming a sheet blank (1) that is at the same time heated by a dynamically moving heating source (5). This dynamic and localised heating locally changes the mechanical properties of the sheet material (1), thus facilitating the forming process.
Type:
Grant
Filed:
April 21, 2006
Date of Patent:
July 26, 2011
Assignee:
K.U. Leuven Research & Development
Inventors:
Bart Callebaut, Joost Duflou, Johan Verbert
Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.
Type:
Grant
Filed:
February 18, 2010
Date of Patent:
June 7, 2011
Assignees:
Gilead Sciences, Inc., K.U. Leuven Research & Development, Gerhard Puerstinger
Inventors:
Steven S. Bondy, David A. Oare, Winston C. Tse
Abstract: A protective helmet is described comprising: an outer layer (1); an inner layer (5) for contact with a head of a wearer; and an intermediate layer (3, 4) comprising an anisotropic cellular material comprising cells having cell walls, the anisotropic cellular material having a relatively low resistance against deformation resulting from tangential forces on the helmet. The anisotropic material can be a foam or honeycomb material. The foam is preferably a closed cell foam. The helmet allows tangential impacts to the helmet which cause less rotational acceleration or deceleration of the head of the wearer compared to helmets using isotropic foams while still absorbing a significant amount of rotational energy.
Type:
Grant
Filed:
July 13, 2005
Date of Patent:
April 26, 2011
Assignee:
K.U. Leuven Research & Development
Inventors:
Bart Depreitere, Jan Goffin, Carl Van Lierde, Bart Haex, Jos Vander Sloten, Remy Van Audekercke, George Van der Perre, Ignace Verpoest, Peter Verschueren, Hans Delye
Abstract: The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.
Type:
Application
Filed:
July 6, 2009
Publication date:
April 14, 2011
Applicant:
K.U. Leuven Research & Development
Inventors:
Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck
Abstract: The present invention relates generally to use of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft co-polymer), such as Kollicoat IR, in the formulation of solid dispersions of low aqueous solubility and dissolution rate bioactive compound and, more particularly to a system and method for improving the solubility and dissolution rate of such low aqueous solubility and dissolution rate bioactive compound, in particular the drug of low aqueous solubility, such as a BCS Class II or Class IV drug compounds.
Abstract: The present invention relates to 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, compositions which comprise said 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, and methods for treating diseases, illnesses, and the like with said 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]decanes.
Type:
Grant
Filed:
December 6, 2005
Date of Patent:
February 15, 2011
Assignees:
K.U. Leuven Research & Development, Universiteit Gent
Inventors:
Roger Bouillon, Pierre De Clercq, Wim Schepens, Maurits Vandewalle, Annemieke Verstuyf
Abstract: Present invention involves a seal means suitable to replace the classic seals. For instance the seal means of present invention can be a liquid seal ring (7) to replace the classic rubber seal rings. Such is liquid O-ring can be adapted to resists the actuation pressure relying on surface tension forces. Such liquid O-rings can also be linked in series, hereby increasing the maximum seal pressure. In a preferred embodiment the seal means of present invention comprises two major components, a surface tension seal (7) and a pressure divider (4). The pressure divider will comprise a system that generates a pressure drop. Such pressure divider can be located before the surface tension seal and perform the first pressure drop. The combination of these two systems has the advantage that the surface tension seal is able to reduce the leakage to zero or essentially zero and that the pressure divider is able to perform a large pressure drop.
Abstract: The present invention provides a testing system allowing the simultaneous comparative evaluation of the behavior in a membrane process of two or more selected membranes (4). In a preferred embodiment said system allows the control of the hydrodynamics of the feeding liquid by means of stirrers (13).
Type:
Grant
Filed:
July 6, 2005
Date of Patent:
October 26, 2010
Assignee:
K.U. Leuven Research and Development
Inventors:
Lieven Gevers, Pieter Vandezande, Johan Paul, Ivo Vankelecom, Pierre Jacobs
Abstract: The invention provides a process of making porous structures or materials, including the colloidal processing (e.g. slip casting, pressure casting, tape casting or electrophoretic deposition) of solid particle emulsions to form a green body that can be directly sintered without a de-binding step.
Type:
Application
Filed:
June 27, 2006
Publication date:
September 16, 2010
Applicant:
K.U. LEUVEN RESEARCH & DEVELOPMENT
Inventors:
Bram Neirinek, Jozef VLEUGELS, Jan FRANSAER, Omer VAN DER BIEST
Abstract: The compound 5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2 -(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine, together with the salts and solvates thereof. Also provided are compositions comprising this compound and pharmaceutically acceptable carriers, as well as the use of such compositions in the treatment or prophylaxis of viral infections.
Type:
Grant
Filed:
January 30, 2008
Date of Patent:
September 14, 2010
Assignees:
Gilead Sciences, Inc., K.U. Leuven Research & Development
Inventors:
Steven S. Bondy, David A. Oare, Winston C. Tse
Abstract: The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C1-C10 alkylene, C2-10 alkenylene or C2-10 alkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR11, provided any such heteroatom is not adjacent to the N in the ring; R3 is selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R10)—, or heterocycle, where each said substituent is optionally substituted with at least one R17, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification.
Type:
Grant
Filed:
July 26, 2005
Date of Patent:
September 7, 2010
Assignees:
Gilead Sciences, Inc., K.U. Leuven Research & Development
Inventors:
Choung U. Kim, Johan Neyts, David A. Oare, Gerhard Puerstinger
Abstract: The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.
Type:
Grant
Filed:
June 7, 2005
Date of Patent:
August 17, 2010
Assignees:
VIB VZW, K.U. Leuven Research and Development
Inventors:
Jan Cools, Anne Hagemeijer, Peter Marynen
Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.
Type:
Grant
Filed:
July 6, 2007
Date of Patent:
July 13, 2010
Assignees:
Gilead Sciences, Inc., K.U. Leuven Research & Development, Gerhard Puerstinger
Inventors:
Steven S. Bondy, Terrence C. Dahl, David A. Oare, Reza Oliyai, Winston C. Tse, Vahid Zia
Abstract: The present invention clearly demonstrates that vWF-collagen interaction, via the A3 domain of vWF, plays an important role in acute platelet-dependent arterial thrombus formation and that blocking the A3 domain in a vWF-collagen interaction can induce complete abolition of thrombus formation in the injured and stenosed baboon femoral arteries. Accordingly, an antibody or an antigen recognizing fragment thereof binding specifically to the A3 domain of vWF or an epitope thereof can be used for the prevention of acute arterial thrombotic syndromes or to manufacture medicines to for the prevention of acute arterial thrombotic syndromes.
Type:
Grant
Filed:
December 18, 2006
Date of Patent:
July 13, 2010
Assignee:
K.U. Leuven Research & Development
Inventors:
Hans Deckmyn, Nancy Cauwenberghs, Karen Vanhoorelbeke
Abstract: The invention describes a new class of crystalline silica material having two levels or porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.
Type:
Grant
Filed:
June 28, 2004
Date of Patent:
July 6, 2010
Assignee:
K.U. Leuven Research & Development
Inventors:
Johan Adriaan Martens, Christine Eva Antonia Kirschhock, Sebastien Philippe Brigitte Kremer, Alexander Jan Maria Herman Eugeen Aerts, Guy Van Den Mooter, Jan Van Humbeeck
Abstract: Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis
Type:
Application
Filed:
March 4, 2010
Publication date:
June 24, 2010
Applicants:
K.U. LEUVEN RESEARCH AND DEVELOPMENT, UNIVERSITEIT GENT
Inventors:
Roger Bouillon, Annemieke Verstuyf, Pierre De Clercq, Maurits Vandewalle
Abstract: A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.
Type:
Application
Filed:
February 18, 2010
Publication date:
June 17, 2010
Applicants:
Gilead Sciences, Inc., K.U. Leuven Research & Development, Gerhard Puerstinger
Inventors:
Steven S. Bondy, Terrenc C. Dahl, David A. Oare, Reza Oliyai, Winston C. Tse, Vahid Zia
Abstract: Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis.
Type:
Grant
Filed:
October 17, 2005
Date of Patent:
April 27, 2010
Assignees:
K.U. Leuven Research and Development, Universiteit Gent
Inventors:
Roger Bouillon, Annemieke Verstuyf, Pierre De Clercq, Maurits Vandewalle