Abstract: The invention relates to an oral pharmaceutical multiple units formulation made up of individual cores containing a pharmacologically active substance, the cores being provided with a coating consisting essentially of a polymer that is insoluble in, impermeable to and non-soluble in water and in gastrointestinal fluids, and a water-soluble pore-creating substance, which is randomly distributed in said polymer, whereby said coated cores form units providing an essential zero order diffusion controlled release rate of said active substance. The invention also comprises a method of preparing these formulations.
Type:
Grant
Filed:
October 4, 1991
Date of Patent:
January 12, 1993
Assignee:
Kabi Pharmacia Aktiebolaq
Inventors:
Karin Malmqvist-Granlund, Christer Hermansson, Soren Kulstad
Abstract: The present invention relates to a nicotine-impermeable container and a method for fabricating same. Additionally, the invention relates to a nicotine inhaling device which allows a user to ingest nicotine vapors orally. The nicotine inhaling device of the present invention is primarily directed to a device which can be used as a smoking cessation aid.
Type:
Grant
Filed:
June 8, 1990
Date of Patent:
December 1, 1992
Assignee:
Kabi Pharmacia Aktiebolaq
Inventors:
James E. Turner, Michael P. Ellis, Ronald G. Oldham, Ira Hill, Bengt E. Malmborg, Sven-Borje Andersson