Patents Assigned to Kabushiki Kaisha Nard Kenkyusho
  • Publication number: 20090185181
    Abstract: The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound.
    Type: Application
    Filed: October 12, 2004
    Publication date: July 23, 2009
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Patent number: 7202093
    Abstract: Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide, and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.
    Type: Grant
    Filed: February 23, 2004
    Date of Patent: April 10, 2007
    Assignee: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Publication number: 20060183237
    Abstract: The present invention provides a method for confirming existence of a phosphoric acid monoester compound (peptide, saccharine and the like) and easily identifying the molecular weight thereof even among biological samples including a plurality of compounds, and an additive for a mass spectrometry used for the method. In the method according to the present invention, a complex compound exhibiting extremely high coordination ability to a phosphoric acid monoester group and configured of single kind of zinc isotopes is used to obtain a plurality of mass spectrum data, and then the data are compared.
    Type: Application
    Filed: December 24, 2003
    Publication date: August 17, 2006
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Norio Minami, Akihiko Kawasaki
  • Publication number: 20040198712
    Abstract: Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods.
    Type: Application
    Filed: February 23, 2004
    Publication date: October 7, 2004
    Applicant: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Tohru Koike, Akihiko Kawasaki, Tatsuhiro Kobashi, Makoto Takahagi
  • Patent number: 5330813
    Abstract: A patch for preventing carburization, nitriding or oxidation comprises:a film comprising a heat-fusible or heat-meltable particulate material having an anti-carburizing, anti-nitriding or anti-oxidizing effect and a heat-decomposable resin as a binder; anda heat-resistant silicone pressure sensitive adhesive, which is decomposed at a carburizing, nitriding or oxidizing temperature, provided on one side of the film.
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: July 19, 1994
    Assignee: Kabushiki Kaisha Nard Kenkyusho
    Inventors: Kouichi Hirooka, Kouichi Ito, Susumu Tanabe
  • Patent number: 4758613
    Abstract: A material for making a pattern used in the investment casting, the material including wax and starch between 2% by weight and 70% by weight.
    Type: Grant
    Filed: March 24, 1986
    Date of Patent: July 19, 1988
    Assignees: Komatsu Haumetto Kabushiki Kaisha, Kabushiki Kaisha Nard Kenkyusho
    Inventors: Shigeru Kawano, Kouichi Hirooka, Susumu Tanabe, Motoko Mishima