Patents Assigned to Kabushiki Kaisha Yakult Honsha
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Publication number: 20240027340Abstract: An imaging device includes a camera, light sources, an optical bandpass filter, and a conversion unit. The camera includes an image sensor including a N-band color filter (where N is a natural number greater than or equal to 3). The M types of light sources (where M is a natural number that satisfies 2?M?N) have the emission spectral characteristics of having respective peaks in mutually different wavelength ranges within a visible light range and a near-infrared range. The conversion unit generates image signals of M bands each having spectral sensitivity to the corresponding one of the mutually different wavelength ranges by performing a matrix operation on an N-band imaging signal obtained by the image sensor when an article is photographed with the camera. The light application direction and the emission intensity are individually selected for each of the light sources.Type: ApplicationFiled: November 11, 2021Publication date: January 25, 2024Applicants: KABUSHIKI KAISHA N-TECH, KABUSHIKI KAISHA YAKULT HONSHA, TOHOSHOJI KABUSHIKI KAISHAInventors: Tohru Watanabe, Hideki Ota, Kunimitsu Toyoshima
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Publication number: 20240002900Abstract: Provided is a method for simply and efficiently collecting microorganisms in fermented milk without affecting the state of cells. A method for collecting microorganisms from a specimen containing fermented milk includes, in this order, steps of: (a) diluting the specimen with a buffer solution such that a protein concentration is 3 mg/mL or less; (b) performing centrifugation; and (c) washing and collecting the microorganisms.Type: ApplicationFiled: November 29, 2021Publication date: January 4, 2024Applicant: KABUSHIKI KAISHA YAKULT HONSHAInventors: Kosuke KATO, Madoka NAKAMURA, Takekazu OKUMURA, Kan SHIDA
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Patent number: 11857584Abstract: Provided is antitumor therapy using oncolytic viruses which exhibits an excellent antitumor effect and has reduced adverse effects. An antitumor agent, comprising a combination of an oncolytic virus and an anticancer agent selected from the group consisting of oxaliplatin, an anticancer plant alkaloid, and an antimetabolite.Type: GrantFiled: March 30, 2018Date of Patent: January 2, 2024Assignees: KABUSHIKI KAISHA YAKULT HONSHAInventors: Hisanobu Ogata, Kenzaburo Tani
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Patent number: 11834695Abstract: The present invention relates to a method for simply diagnosing the progress of disease condition of a Parkinson's disease patient. Provided are a method for determining Parkinson's disease using the number of one or more intestinal bacteria selected from the group consisting of Bifidobacterium, Bacteroides fragilis group, Lactobacillus brevis, and Lactobacillus plantarum subgroup and/or the total number of intestinal bacteria as a marker, and a method for determining Parkinson's disease using the blood LPS level and/or the blood LBP level of a Parkinson's disease patient as an indicator.Type: GrantFiled: May 17, 2018Date of Patent: December 5, 2023Assignees: KABUSHIKI KAISHA YAKULT HONSHA, NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Hirokazu Tsuji, Takashi Asahara, Koji Nomoto, Masaaki Hirayama, Kinji Ohno
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Publication number: 20230334649Abstract: A print inspection device includes a camera that captures a character printed on an inspection target, a shape matching processor, a deformation pattern generator, and an inspection processor. The shape matching processor checks a shape of a captured character pattern included in a captured image obtained by the camera against a shape of a preset reference character pattern while changing a deformation degree of the shape of the reference character pattern and searches for a matched character. The deformation pattern generator generates a deformed character pattern obtained by deforming the reference character pattern at the deformation degree to which the character is matched in the shape matching process. The inspection processor inspects whether a printed state of the character is satisfactory from a result of the comparison between the deformed character pattern and the captured character pattern.Type: ApplicationFiled: April 28, 2021Publication date: October 19, 2023Applicants: KABUSHIKI KAISHA N-TECH, KABUSHIKI KAISHA YAKULT HONSHA, TOHOSHOJI KABUSHIKI KAISHAInventors: Shenglan Li, Kazumi Banno, Masaki Nagase, Hideki Ota, Kunimitsu Toyoshima
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Patent number: 11718841Abstract: Provided is a method for improving the production amount of a tri- or higher galactooligosaccharide and the reaction rate by a method for producing a galactooligosaccharide characterized by allowing ?-galactosidase to react with a substrate in the presence of 5 to 60 mM sodium ions and 0.5 to 8 mM magnesium ions.Type: GrantFiled: December 22, 2021Date of Patent: August 8, 2023Assignee: KABUSHIKI KAISHA YAKULT HONSHAInventors: Masakazu Ikeda, Masahiko Ito
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Patent number: 11655493Abstract: A marker for determining a mental disease is provided. The marker can be used in an objective diagnosis of such a mental disease. The marker contains one or more enterobacteria of Bifidobacterium, Lactobacillus, Lactobacillus brevis, Lactobacillus reuteri subgroup, Lactobacillus sakei subgroup, Atopobium cluster, Bacteroides fragilis group, Enterococcus, Clostridium coccoides group, Clostridium leptum subgroup, Staphylococcus, Clostridium perfringens, and Enterobacteriaceae.Type: GrantFiled: April 15, 2016Date of Patent: May 23, 2023Assignees: NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, KABUSHIKI KAISHA YAKULT HONSHAInventors: Hiroshi Kunugi, Emiko Aizawa, Hirokazu Tsuji
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Patent number: 11644458Abstract: A method is shown for preparing a specimen for extensively analyzing a resident skin bacterium and/or a substance present in the stratum corneum, such as a protein or a lipid, or observing the shape of the stratum corneum. A method for preparing a specimen for analyzing a resident skin bacterium and/or a substance present m the stratum corneum or observing the shape of the stratum, includes applying a solution containing a polyvinyl alcohol polymer to the skin so as to form a thin-film and peeling and collecting the formed thin-film.Type: GrantFiled: August 31, 2017Date of Patent: May 9, 2023Assignee: KABUSHIKI KAISHA YAKULT HONSHAInventors: Daisuke Niwa, Akemi Imaoka, Naoki Izawa, Yasuyuki Takahashi, Miyuki Kudo
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Publication number: 20230119275Abstract: Provided is a pharmaceutical composition suitable for administration of anticancer drugs into lymph nodes by means of lymphatic drug delivery systems. A pharmaceutical composition for therapeutic or prophylactic treatment of cancer to be administered into lymph nodes, comprising at least one anticancer drug selected from the group consisting of antimetabolites and anticancer plant alkaloids as an active ingredient.Type: ApplicationFiled: December 8, 2022Publication date: April 20, 2023Applicants: TOHOKU UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHAInventors: Tetsuya KODAMA, Shiro MORI, Go NOHARA
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Patent number: 11566017Abstract: Provided is a cell proliferation inhibitor comprising a compound of the formula (1) or a pharmacologically acceptable salt thereof: wherein J1 and J2 each represent CH or N, with the proviso that J1 and J2 are not simultaneously CH; r represents 0 to 4; each R101 is the same or different when r is 2 or more, and R101 represents a C1-6 alkyl group optionally substituted with a halogen atom or the like; s represents 0 to 5; each R102 is the same or different when s is 2 or more, and R102 represents a halogen atom or the like; R103 represents a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkyl C1-6 alkyl group; and R101 and R103 are optionally linked together to form a five- to seven-membered ring hetero ring when R101 is present at the 8-position.Type: GrantFiled: December 26, 2018Date of Patent: January 31, 2023Assignees: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH, KABUSHIKI KAISHA YAKULT HONSHAInventors: Minoru Yoshida, Hiroyuki Seimiya, Yoko Yashiroda, Kenichi Washizuka, Fumiyuki Shirai, Nobuko Yoshimoto, Junichi Kazami
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Patent number: 11559526Abstract: Provided is a pharmaceutical composition suitable for administration of anticancer drugs into lymph nodes by means of lymphatic drug delivery systems. A pharmaceutical composition for therapeutic or prophylactic treatment of cancer to be administered into lymph nodes, comprising at least one anticancer drug selected from the group consisting of antimetabolites and anticancer plant alkaloids as an active ingredient.Type: GrantFiled: August 31, 2017Date of Patent: January 24, 2023Assignees: TOHOKU UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHAInventors: Tetsuya Kodama, Shiro Mori, Go Nohara
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Publication number: 20220386637Abstract: Using a method for producing fermented milk containing an oligosaccharide and a lactic acid bacterium as a living bacterium that cultures the lactic acid bacterium in a medium containing the oligosaccharide and fermented milk produced by the production method, a high viable bacterial count can be maintained even during long-term preservation in the fermented milk containing the oligosaccharide and the lactic acid bacterium as a living bacterium.Type: ApplicationFiled: October 22, 2020Publication date: December 8, 2022Applicant: KABUSHIKI KAISHA YAKULT HONSHAInventors: Maiko NAKAMORI, Shiori IGARASHI, Daichi NIHEI
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Patent number: 11499138Abstract: Provided is a method for efficiently manufacturing high-purity peripheral nerve cells from undifferentiated cells. The method for manufacturing peripheral nerve cells from undifferentiated cells having an ability to differentiate into peripheral nerve cells includes the following steps (a) and (b): (a) culturing undifferentiated cells having an ability to differentiate into peripheral nerve cells to induce differentiation into neural progenitor cells without detaching a grown colony from a culture vessel; and (b) detaching the neural progenitor cells produced in the step (a) from the culture vessel, then seeding the cells at a seeding density of 2×105 to 6×105 cells/cm2 to a culture vessel, and culturing the cells for 14 to 42 days.Type: GrantFiled: October 20, 2017Date of Patent: November 15, 2022Assignees: NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHAInventors: Masahiko Nishiyama, Susumu Rokudai, Shinji Yoshiyama, Hiroyuki Takahashi
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Publication number: 20220356439Abstract: Provided a method for promoting growth of bacteria of the genus Bifidobacterium. The method for promoting growth of bacteria of the genus Bifidobacterium includes subjecting a milk culture medium containing one or more selected from the group consisting of cysteine, cystine, and a salt thereof to heat treatment and then culturing bacteria of the genus Bifidobacterium in the milk culture medium.Type: ApplicationFiled: June 24, 2020Publication date: November 10, 2022Applicant: KABUSHIKI KAISHA YAKULT HONSHAInventors: Kosuke KATO, Kaoru TOCHIYA, Takekazu OKUMURA
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Patent number: 11457641Abstract: An object of the present invention is to provide a fermented milk food, in which the viability of lactic acid bacteria during storage is high, the increase in acidity is suppressed, the viable cell count is less reduced, and the flavor is less deteriorated. A method for producing a fermented milk food by which the object was achieved is characterized by inoculating and culturing lactic acid bacteria in a culture medium containing a milk as a main component and supplemented with glucose in such an amount that glucose is substantially entirely assimilated at the time of completion of culturing and fructose in an amount twice or more the amount of glucose in a mass ratio.Type: GrantFiled: February 12, 2016Date of Patent: October 4, 2022Assignee: Kabushiki Kaisha Yakult HonshaInventors: Ryotaro Hoshi, Junki Saito
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Patent number: 11414429Abstract: Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.Type: GrantFiled: June 30, 2017Date of Patent: August 16, 2022Assignees: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH, KABUSHIKI KAISHA YAKULT HONSHAInventors: Minoru Yoshida, Hiroyuki Seimiya, Masayuki Okue, Yoko Yashiroda, Fumiyuki Shirai, Takeshi Tsumura, Yuko Kano, Kenichi Washizuka, Nobuko Yoshimoto, Yasuko Kouda, Takehiro Fukami, Tsubasa Chikada, Takashi Watanabe
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Publication number: 20220248687Abstract: Provided is a method for promoting bacterial cell wall degradation. A method for promoting cell wall degradation, comprising allowing an N-acetylmuramidase to act on a bacterium in the presence of one or more saccharides selected from the group consisting of: a monosaccharide wherein the monosaccharide is an aldopentose, an L-aldohexose, or a ketohexose; a disaccharide, an oligosaccharide, and a polysaccharide each containing one or more of the monosaccharides as a constituent saccharide; and a derivative thereof.Type: ApplicationFiled: March 23, 2020Publication date: August 11, 2022Applicant: KABUSHIKI KAISHA YAKULT HONSHAInventors: Kosuke KATO, Takekazu OKUMURA, Akira KUSHIRO
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Patent number: 11406113Abstract: A tien-cha extract essence characterized by being obtained by subjecting a tien-cha extract to an activated carbon treatment, and a method for producing a fermented food product using the tien-cha extract essence provide a technique which can be replaced for a tien-cha essence obtained by subjecting a tien-cha extract to electrodialysis having various problems, has no effect on flavor while maintaining the effects of the tien-cha extract of increasing the growth ability of lactic acid bacteria and the viability or the like of bifidobacterium bacteria, has an unprecedented effect of increasing the growth ability of bifidobacterium bacteria, and facilitates production and powderization.Type: GrantFiled: March 22, 2016Date of Patent: August 9, 2022Assignee: Kabushiki Kaisha Yakult HonshaInventors: Ryotaro Hoshi, Masatoshi Nakano, Daisuke Nozaki, Takao Suzuki
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Patent number: 11390691Abstract: Provided are: an oligosaccharide powder having high working properties, the oligosaccharide powder being characterized by containing a dextrin having a dextrose equivalent of 10 to 18 and an oligosaccharide; and a method for manufacturing the same.Type: GrantFiled: May 23, 2018Date of Patent: July 19, 2022Assignee: KABUSHIKI KAISHA YAKULT HONSHAInventors: Masakazu Ikeda, Ryo Aoki, Masahiko Ito
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Publication number: 20220218693Abstract: Provided is a method for using a STAT3 inhibitor which exhibits an excellent antitumor effect. An antitumor agent comprises a quinoline carboxamide derivative of formula (I) below or a salt thereof as an active ingredient, and is administered in combination with an immune checkpoint inhibitor. The antitumor agent is administered before the administration of the immune checkpoint inhibitor.Type: ApplicationFiled: April 23, 2020Publication date: July 14, 2022Applicants: KABUSHIKI KAISHA YAKULT HONSHA, GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATIONInventors: Akira ASAI, Nao MIYOSHI, Daisuke MURAOKA, Naohisa OGO, Hiroyuki TAKAHASHI