Patent number: 7022677
Abstract: Disclosed are the novel compounds as growth hormone secretagogues represented by structural Formula (I), wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is —CO— or —SO2—, Y is Formula (II), wherein n is an integer from 0–4, R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, R5 and R6 are independently selected from hydrogen, substituted or unsubstituted alkyl, or R5 and R6 or R4 and R5 are taken together to form substituted or unsubstituted alkylene, R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and ph
Type:
Grant
Filed:
February 17, 2000
Date of Patent:
April 4, 2006
Assignees:
Kaken Pharmaceutical Co., Ltd., Molecular Research Institute
Inventors:
Nobuo Ishiyama, Hirohide Ishige, Mitsuo Mimura, Tadashi Okuno, Kiyoharu Ukai, Takeshi Kiyofuji, Shinji Tauchi, Kiyoshi Inoguchi, Ping Huang, Linda J. Maki, legal representative, Gilda H. Loew, deceased
Publication number: 20060014701
Abstract: Disclosed are the novel compounds as growth hormone secretagogues represented by the structural Formula I: wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is —CO— or —SO2—, Y is: wherein n is an integer from 0-4, R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, R5 and R6 are independently selected from hydrogen, substituted or unsubstituted alkyl, or R5 and R6 or R4 and R5 are taken together to form substituted or unsubstituted alkylene, R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and phar
Type:
Application
Filed:
September 6, 2005
Publication date:
January 19, 2006
Applicants:
Kaken Pharmaceutical Co., Ltd., Molecular Research Institute
Inventors:
Nobuo Ishiyama, Hirohide Ishige, Mitsuo Mimura, Tadashi Okuno, Kiyoharu Ukai, Takeshi Kiyofuji, Shinji Tauchi, Kiyoshi Inoguchi, Ping Huang, Gilda Loew, Linda Maki