Patents Assigned to Kalypsys, Inc.
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 9078887
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: July 14, 2015
    Assignees: Kalypsys, Inc., Alcon Laboratories, Inc.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • Heterocyclic inhibitors of histamine receptors for the treatment of disease
    Patent number: 8859550
    Abstract: The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of diseases including allergic rhinitis.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 14, 2014
    Assignee: Kalypsys, Inc.
    Inventors: Pingyun Chen, Stephen A. R. Carino, Ricky Wayne Couch, Daniel S. Kinder, Beth A. Norton
  • Substituted tetrazolo[1,5-A]pyrazine inhibitors of histamine receptors for the treatment of disease
    Patent number: 8569300
    Abstract: The present invention relates to substituted tetrazolo[1,5-a]pyrazine compounds for Formula IX: as well as pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: October 29, 2013
    Assignee: Kalypsys Inc.
    Inventors: Allen Borchardt, Robert Davis, Stewart A. Noble
  • SULFONYL-SUBSTITUTED BICYCLIC COMPOUNDS AS PPAR MODULATORS FOR THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS
    Publication number: 20130252970
    Abstract: Disclosed herein are new methods of treatment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and other fibrotic diseases of the liver in a subject by modulating PPAR? with sulfonyl-substituted bicyclic compounds and compositions as pharmaceuticals.
    Type: Application
    Filed: May 14, 2013
    Publication date: September 26, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Mausumee Guha, Paul Grint
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20130245001
    Abstract: The present invention relates to salts, hydrates, and polymorphs of bicyclic heteroaryl compounds, and pharmaceutical compositions thereof, which may be useful as inhibitors of H4R for the treatment or prevention of diseases including allergic rhinitis.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 19, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Pingyun Chen, Stephen A.R. Carino, Ricky Wayne Couch, Daniel S. Kinder, Beth A. Norton
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20130178498
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: June 28, 2012
    Publication date: July 11, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20130116279
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: November 7, 2011
    Publication date: May 9, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • BICYCLIC HETEROARYL INHIBITORS OF PDE4
    Publication number: 20130045975
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: February 10, 2012
    Publication date: February 21, 2013
    Applicant: KALYPSYS, INC.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • Bicyclic heteroaryl inhibitors of PDE4
    Patent number: 8258154
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: September 4, 2012
    Assignee: Kalypsys Inc.
    Inventors: Steven Govek, Andrew K. Shiau, Stewart A. Noble, David J. Thomas
  • Heteroarylalkoxy-substituted quinolone inhibitors of PDE4
    Patent number: 8138205
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: March 20, 2012
    Assignee: Kalypsys, Inc.
    Inventors: Steven P. Govek, Clay Beauregard, Daniel A. Gamache, Mark R. Hellberg, Stewart A. Noble, Andrew K. Shiau, David J. Thomas, John M. Yanni
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20120065187
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: November 21, 2011
    Publication date: March 15, 2012
    Applicants: ALCON RESEARCH, LTD, KALYPSYS, INC.
    Inventors: Allen J. Borchardt, Clay Beauregard, Travis Cook, Robert L. Davis, Daniel A. Gamache, John M. Yanni
  • Carbazole inhibitors of histamine receptors for the treatment of disease
    Patent number: 8080566
    Abstract: The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: December 20, 2011
    Assignee: Kalypsys, Inc
    Inventors: Mehmet Kahraman, Allen J. Borchardt, Robert L. Davis, Stewart A. Noble, James W. Malecha
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110257137
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 10, 2011
    Publication date: October 20, 2011
    Applicant: KALYPSYS, INC.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Becker, Daniel Gamache, Stewart A. Noble, Mark Hellberg, Peter Klimko, Zhihai Qiu, Joseph Payne, John Yanni
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110237599
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 9, 2011
    Publication date: September 29, 2011
    Applicant: Kalypsys, Inc.
    Inventors: Allen Borchardt, Robert Davis, Clay Beauregard, Daniel Gamache, Mark Hellberg, Peter Klimko, John Yanni
  • HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
    Publication number: 20110237565
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
    Type: Application
    Filed: March 10, 2011
    Publication date: September 29, 2011
    Applicant: KALYPSYS, INC.
    Inventors: Allen Borchardt, Robert Davis, Stewart A. Noble
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7915253
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: March 29, 2011
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen K. Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D. Bayne, Mehmet Kahraman, Boliang Lou, Steve P. Govek
  • Salts of modulators of PPAR and methods of treating metabolic disorders
    Patent number: 7863276
    Abstract: Salt forms of potent modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: January 4, 2011
    Assignee: KALYPSYS, Inc
    Inventors: Dennis A. Bennett, Stephan D. Parent, David T. Jonaitis
  • Sulfonyl-substituted bicyclic compounds as modulators of PPAR
    Patent number: 7834004
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: November 16, 2010
    Assignee: Kalypsys, Inc
    Inventors: Stewart A. Noble, Guy Oshiro, James W. Malecha, Cunxiang Zhao, Carmen Robinson, Sergio G. Duron, Michael Sertic, Andrew K. Lindstrom, Andrew K. Shiau, Christopher D Bayne, Mehmet Kahraman, Boliang Lou, Steven P. Govek
  • Inducible nitric oxide synthase dimerization inhibitors
    Patent number: 7825256
    Abstract: The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula: wherein T, X, and Y are independently selected from the group consisting of CR4, N, NR4, S, and O; U is selected from the group consisting of CR10 and N; V is selected from the group consisting of CR4 and N; W and W? are independently selected from the group consisting of CH2, CR7R8, NR9, O, N(O), S(O)q and C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: November 2, 2010
    Assignee: Kalypsys, Inc.
    Inventors: Timothy C. Gahman, Hengyuan Lang, Mark R. Herbert, Angelina M. Thayer, Christian A. Hassig, Stewart A. Noble, Russell D. Cousins, Hui Zhuang, Christopher R. Santos, Xiaohong Chen
  • MULTI-WELL PLATE LID WITH PROTECTIVE SKIRT
    Publication number: 20100202927
    Abstract: A plate lid for covering a multi-well plate for use in a high throughput screening (HTS) process. The lid includes a plate section dimensioned to cover the plate, a frame block positioned on the underside perimeter of the plate section to form a recessed center, a skirt section protruding from each edge of the frame block; and a gasket layer positioned on the frame block for sealing the peripheral surface of the multi-well plate.
    Type: Application
    Filed: January 11, 2008
    Publication date: August 12, 2010
    Applicant: KALYPSYS, INC.
    Inventors: Paul J. Queeney, Rose Hughes