Patents Assigned to Kansas University Medical Center Research Institute, Inc.
  • THERAPEUTIC ALKALINE PROTEASE COMPOSITIONS AND USE IN FACILITATING THE TRANSPORT OF AGENTS ACROSS THE GASTROINTESTINAL MUCOSAL LINING
    Publication number: 20090068174
    Abstract: A method of treating an inflammatory condition involving TNF-? in a mammal by administering to a patient a composition with an effective amount of an isolated alkaline protease in an amount effective to inactive TNF-?. The invention also involves compositions, including pharmaceutical compositions containing an isolated alkaline protease in an amount effective to inactive TNF-? especially those from Aspergillus oryzae and/or serve as a transepithial carrier.
    Type: Application
    Filed: September 12, 2007
    Publication date: March 12, 2009
    Applicant: Kansas University Medical Center Research Institute, Inc.
    Inventors: Michael J. Parmely, Rohit Medhekar, Anthony Collier
  • Dialysis solutions and methods
    Patent number: 6436969
    Abstract: The present invention provides improved dialysis compositions and methods for dialysis comprising utilizing the disclosed AGE inhibitors, together with methods to reduce dialysis-related complications and disorders.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: August 20, 2002
    Assignee: Kansas University Medical Center Research Institute Inc.
    Inventors: Raja Gabriel Khalifah, Billy G. Hudson
  • Method of producing bone-inducing agent
    Patent number: 6322786
    Abstract: The present invention provides methods to isolate and purify components required for bone-induction using extracts of Saos-2 cells or proteins released by Saos-2 cells into conditioned tissue culture medium. In addition, the present invention provides a method of augmenting bone growth locally comprising implanting the near osteoprogenitor cells the bone inducing agent isolated in the methods of the present invention, together with a mechanically suitable biodegradable carrier.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: November 27, 2001
    Assignee: Kansas University Medical Center Research Institute, Inc.
    Inventor: H. C. Anderson