Abstract: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
Type:
Grant
Filed:
November 19, 1999
Date of Patent:
October 16, 2001
Assignee:
Kason Biosciences, Inc.
Inventors:
Bryan Julien, Leonard Katz, Chaitan Khosla, Li Tang