Patents Assigned to Kefalas A/S
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Patent number: 4525360Abstract: The present invention relates to novel phenylindene derivatives having interesting pharmacodynamic properties which make them useful as psychopharmacologicals in the treatment especially of psychoses such as schizophrenia, having a low degree of undesired side effects such as cataleptic effects, methods for the preparation of said phenylindene derivatives, pharmaceutical compositions containing same, and methods for the treatment of psychic disorders, such as psychoses and depressions and pain, by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.Type: GrantFiled: October 5, 1983Date of Patent: June 25, 1985Assignee: Kefalas A/SInventor: Jens K. Perregaard
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Patent number: 4443448Abstract: The present invention relates to novel 1-piperazino-3-phenyl-indane derivatives which have pronounced psychopharmacological activity such as neuroleptic activity, analgesic activity, antidepressant activity and, at the same time, a low degree of undesired side-effects, methods for the preparation of said indane derivatives, pharmaceutical compositions containing same, and methods for the treatment of psychic disorders, such as psychoses and depressions and pain, by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.Type: GrantFiled: February 26, 1981Date of Patent: April 17, 1984Assignee: Kefalas A/SInventor: Klaus P. Bogeso
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Patent number: 4384140Abstract: The present invention relates to novel aminoalkyl substituted nitrosourea derivatives as well as their acid addition salts with pharmaceutically acceptable acids showing pronounced antineoplastic effectiveness in animal experiments.The novel compounds of the present invention may be represented by the following formula: ##STR1## wherein X and Y are the same or different, and are selected from the group consisting of a phenyl group and a cyclohexyl group, said phenyl and cyclohexyl groups being optionally substituted with one or two substituents selected from a halogen atom, a lower alkyl group having from one to four carbon atoms inclusive, a trifluore methyl group, a cyano group, a phenyl group, a cyclohexyl group and a lower alkyloxy group having from one to four carbon atoms inclusive."Alkylene" is an alkylene group, branched or unbranched, having from one to four carbon atoms inclusive, and R.sup.1 and R.sup.Type: GrantFiled: February 16, 1982Date of Patent: May 17, 1983Assignee: Kefalas A/SInventors: Peter Bregnedal, Jorn L. M. Buus
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Patent number: 4367239Abstract: The present invention relates to novel aminoalkyl substituted nitrosourea derivatives as well as their acid addition salts with pharmaceutically acceptable acids showing pronounced antineoplastic effectiveness in animal experiments.The novel compounds of the present invention may be represented by the following formula: ##STR1## wherein X and Y are the same or different, and are selected from the group consisting of a phenyl group and a cyclohexyl group, said phenyl and cyclohexyl groups being optionally substituted with one or two substituents selected from a halogen atom, a lower alkyl group having from one to four carbon atoms inclusive, a trifluore methyl group, a cyano group, a phenyl group, a cyclohexyl group and a lower alkyloxy group having from one to four carbon atoms inclusive."Alkylene" is an alkylene group, branched or unbranched, having from one to four carbon atoms inclusive, and R.sup.1 and R.sup.Type: GrantFiled: September 29, 1980Date of Patent: January 4, 1983Assignee: Kefalas A/SInventors: Peter Bregnedal, Jorn Buus
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Patent number: 4353910Abstract: Carbamoyl derivatives of 4,5,6,7-Tetrahydroisoxazolo[5,4-c] Pyridine-3-one, and method of preparation, pharmaceutical compositions thereof, and methods of treatment of GABA-system malfunctions therewith, are all disclosed.Type: GrantFiled: November 27, 1981Date of Patent: October 12, 1982Assignee: Kefalas A/SInventor: Jens K. Perregaard
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Patent number: 4309429Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.Type: GrantFiled: December 21, 1979Date of Patent: January 5, 1982Assignee: Kefalas A/SInventors: Niels Lassen, Klaus P. Bogeso, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
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Patent number: 4285956Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.Type: GrantFiled: May 3, 1979Date of Patent: August 25, 1981Assignee: Kefalas A/SInventors: Niels Lassen, Klaus P. Boges, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
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Patent number: 4275209Abstract: The present invention relates to novel thioxanthene and xanthene derivatives which have useful pharmacodynamic activity, such as neuroleptic activity and antiemetic activity, methods for the preparation of said derivatives, pharmaceutical compositions containing same, and a method for the treatment of psychic disorders by administering a therapeutically active amount of one of said derivatives to a living animal body, including human beings.Type: GrantFiled: December 21, 1979Date of Patent: June 23, 1981Assignee: Kefalas A/SInventors: Niels Lassen, Klaus P. Bogeso, Peter B. Hansen, Jorn L. M. Buus, Allan J. Bigler
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Patent number: 4235916Abstract: The present invention relates to the novel compound 2-methylthio-6-fluoro-9-(1-methyl-4-piperidylidene)-thioxanthene of the formula ##STR1## and its non-toxic acid addition salts, which compounds have strong and longlasting neuroleptic properties and, at the same time, a low degree of undesired side effects such as extrapyrimidal side effects.The invention moreover relates to a method for the preparation of said novel compounds, pharmaceutical compositions containing same, which may be administered to animals, including human beings, orally or parentally.Further the invention relates to a method for producing an antipsychotic effect in warmblooded animals by administering to said animals an antipsychotically effective amount of one of said novel compounds.Type: GrantFiled: December 20, 1978Date of Patent: November 25, 1980Assignee: Kefalas A/SInventor: Klaus P. Bogeso
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Patent number: 4232021Abstract: Pharmaceutical compositions comprising essentially pure trans-9-[3-(4-hydroxyethyl-1-piperazinyl)propylidene]-2-trifluoromethylthi axanthene or pharmaceutically acceptable acid addition salts thereof and a pharmaceutical carrier and methods for treating depression which comprises administering said pharmaceutical compositions.Type: GrantFiled: January 25, 1979Date of Patent: November 4, 1980Assignee: Kefalas A/SInventors: Bruno P. H. Poschel, Donald R. Maxwell
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Patent number: 4153694Abstract: The present invention relates to novel behenic acid esters of the following general formula: ##STR1## wherein X is "N" or "CH," the non-toxic acid addition salts thereof, a method for the preparation of said esters and therapeutic compositions thereof having prolonged effect.It is an object of the present invention to provide behenic acid esters of Formula I, a method of making the same, a method for the alleviation, palliation, mitigation or inhibition of the manifestations of certain physiological-psychological abnormalities of animals therewith, and pharmaceutical compositions comprising such compounds as active ingredient.Other objects will be apparent to one skilled in the art and still other objects will become apparent hereinafter.Type: GrantFiled: August 19, 1977Date of Patent: May 8, 1979Assignee: Kefalas A/SInventors: Jorn L. M. Buus, Niels Lassen
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Patent number: 4136193Abstract: The present invention relates to phthalans of the following general formula: ##STR1## wherein R.sup.1 and R.sup.2 each represents halogen, a trifluoromethyl group, a cyano group or R--CO-- wherein R is an alkyl-radical with from 1-4 C-atoms inclusive, as well as acid addition salts thereof with pharmaceutically acceptable acids.Type: GrantFiled: January 7, 1977Date of Patent: January 23, 1979Assignee: Kefalas A/SInventors: Klaus P. Bogeso, Anders S. Toft
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Patent number: 4044024Abstract: Fluoro-substituted thiaxanthene derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, methods of preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.Type: GrantFiled: July 7, 1975Date of Patent: August 23, 1977Assignee: Kefalas A/SInventors: Jorn Lasse Martin Buus, Niels Lassen, Allan Johan Bigler
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Patent number: 4042695Abstract: Fluoro-substituted thiaxanthene derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, methods of preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.Type: GrantFiled: August 13, 1975Date of Patent: August 16, 1977Assignee: Kefalas A/SInventors: Jorn Lasse Martin Buus, Niels Lassen, Allan Johan Bigler
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Patent number: 4038395Abstract: The present invention relates to the novel alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof, the non-toxic acid addition salts of these compounds, methods of preparing and purifying the said compounds, therapeutic compositions thereof and a method of treating psychotic patients therewith.Type: GrantFiled: June 16, 1976Date of Patent: July 26, 1977Assignee: Kefalas A/SInventor: Niels Lassen
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Patent number: 4035503Abstract: The present invention relates to novel xanthene and thioxanthene derivatives of the following general formula: ##STR1## wherein Y represents sulfur or oxygen, R.sup.1 represents hydrogen, chlorine, trifluoromethyl or dimethylsulfamoyl, R.sup.2 represents hydrogen or fluorine; and R.sup.3 and R.sup.4 each represents hydrogen or methyl, provided that R.sup.3 and R.sup.4 may not both represent hydrogen, or R.sup.3 and R.sup.4 taken together with the nitrogen atom form a piperazine or piperidine ring optionally substituted in the 4-position by a methyl group or a 2-hydroxyethyl group, if desired, esterified with an aliphatic carboxylic acid having from one to seventeen carbon atoms inclusive, as well as non-toxic acid addition salts thereof.Type: GrantFiled: March 1, 1976Date of Patent: July 12, 1977Assignee: Kefalas A/SInventors: Georg Ujvari, Peter Bregnedal Hansen
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Patent number: 4022896Abstract: The present invention relates to novel xanthene and thioxanthene derivatives of the following general formula: ##STR1## wherein Y represents sulfur or oxygen, R.sup.1 represents hydrogen, chlorine, trifluoromethyl or dimethylsulfamoyl,R.sup.2 represents hydrogen or fluorine; and R.sup.3 and R.sup.4 each represents hydrogen or methyl, provided that R.sup.3 and R.sup.4 may not both represent hydrogen, or R.sup.3 and R.sup.4 taken together with the nitrogen atom form a piperazine or piperidine ring optionally substituted in the 4-position by a methyl group or a 2-hydroxyethyl group, if desired, esterified with an aliphatic carboxylic acid having from one to seventeen carbon atoms inclusive, as well as non-toxic acid addition salts thereof.Type: GrantFiled: March 1, 1976Date of Patent: May 10, 1977Assignee: Kefalas A/SInventors: Georg Ujvari, Peter Bregnedal Hansen
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Patent number: 3996211Abstract: The present invention relates to the novel alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof, the non-toxic acid addition salts of these compounds, methods of preparing and purifying the said compounds, therapeutic compositions thereof and a method of treating psychotic patients therewith.Type: GrantFiled: June 17, 1974Date of Patent: December 7, 1976Assignee: Kefalas A/SInventor: Niels Lassen
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Patent number: 3966952Abstract: This invention relates to the novel alpha-isomer of the palmitic acid ester of 10-[3-(4-hydroxyethyl-1-piperazinyl) propylidene]-2-trifluoromethyl thiaxanthene, the non-toxic acid addition salts thereof, methods for the preparation of the said compound, therapeutic compositions thereof having prolonged effect, and a method of treating psychotic patients therewith.Type: GrantFiled: December 4, 1974Date of Patent: June 29, 1976Assignee: Kefalas A/SInventor: Jorn Lasse Martin Buus
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Patent number: 3966930Abstract: Fluoro-substituted phenothiazine derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, a method for the preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.Type: GrantFiled: May 30, 1974Date of Patent: June 29, 1976Assignee: Kefalas A/SInventors: Jorn Lasse Martin Buus, Niels Lassen