Patents Assigned to Keio University
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Publication number: 20240127025Abstract: A passive wireless tag to identify a given command which has been received, even while responding to a wireless tag communication device. In this wireless tag, radio waves serving as a predetermined command are received from a wireless tag communication device via an antenna and an RF switch. Signal components are detected from the received radio waves by the detection circuit. The detected signal components are sampled by the sampling circuit in accordance with the timing when the RF switch is controlled to its ON state by a predetermined control signal. The time interval of the ON state is set to be sufficiently shorter than a transfer cycle of the received radio waves. The control circuit thus identifies the foregoing predetermined command according to the sampling results obtained from the sampling circuit.Type: ApplicationFiled: January 26, 2022Publication date: April 18, 2024Applicants: KEIO UNIVERSITY, DENSO WAVE INCORPORATEDInventors: Jin MITSUGI, Haruki SAKABE
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Publication number: 20240124836Abstract: Provided is a method of differentiating a pluripotent stem cell of mammalian origin into a desired cell type by predicting the direction of cell differentiation to be caused by induction of expression of a transcription factor. A human gene expression correlation matrix using human cells has been newly created, and further, it has been confirmed that human pluripotent stem cells can be differentiated into a desired cell type by introducing, into the human pluripotent stem cells, a transcription factor cocktail selected from the matrix.Type: ApplicationFiled: December 21, 2023Publication date: April 18, 2024Applicant: KEIO UNIVERSITYInventor: Minoru Ko
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Publication number: 20240122523Abstract: A symptom determination apparatus according to the present embodiment includes an EEG feature detection section and a symptom determination section. The EEG feature detection section detects one or a plurality of frequency components of an EEG signal in a certain brain area of a subject. The symptom determination section determines a depressive symptom in the subject based on the intensity of the one or plurality of frequency components of the EEG signal detected by the EEG feature detection section.Type: ApplicationFiled: January 28, 2022Publication date: April 18, 2024Applicant: KEIO UNIVERSITYInventors: Yasue MITSUKURA, Taishiro KISHIMOTO, Yuki TAZAWA
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Patent number: 11957475Abstract: A biometric information processing device (1) includes a brain wave detecting unit (10), a control unit (20), and a movement assisting unit (30). The brain wave detecting unit (10) detects biometric information in at least one brain region from among a plurality of brain regions that are selectable in accordance with a body part that is a target of function recovery or function improvement. The control unit (20) determines, based on the detected biometric information, at least one activity state in the brain including the location of the brain region(s) that is (are) activated in a subject while attempting to move the body part, and an activation level of such activated brain region(s). When the control unit (20) determines that the at least one activated state of the brain satisfies a predetermined condition, the movement assisting unit (30) executes a predetermined motion to assist movement of the body part.Type: GrantFiled: May 15, 2017Date of Patent: April 16, 2024Assignee: KEIO UNIVERSITYInventors: Junichi Ushiba, Fumio Liu, Kenichi Takasaki, Atsuko Nishimoto, Miho Hiramoto, Katsuhiro Mizuno, Meigen Liu, Toshiyuki Fujiwara
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Patent number: 11956028Abstract: A module and system are provided for reducing or suppressing ringing occurring in a digital signal to be transmitted. A transmission module Ma includes a transmitter 200a configured to transmit a digital signal, a transmission antenna 100a constituted by a metal plate, or by a conductor formed on an insulator, the transmission antenna 100a being configured to be electromagnetically or magnetically coupled to a reception antenna 100b of a non-contact reception module Mb for digital communication, and a resistor 400a connected in series between the transmitter 200a and the transmission antenna 100a. The resistor 400a has such a resistance value that the resistor 400a entirely blunts a waveform of the digital signal outputted from the transmitter 200a so as to reduce or suppress ringing occurring in the digital signal. The blunted digital signal is to be inputted into the transmission antenna 100a.Type: GrantFiled: March 12, 2021Date of Patent: April 9, 2024Assignees: HOSIDEN CORPORATION, KEIO UNIVERSITYInventors: Hayato Kondo, Kosuke Sasada, Tadahiro Kuroda
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Publication number: 20240095850Abstract: A non-transitory computer-readable storage medium storing therein an information management program for causing a computer to execute a process comprises: receiving property information indicating a reliability of a post uploaded on the Internet and a digital signature generated from the property information; and storing the property information, to which identification information of the post and the digital signature are added, in a storage.Type: ApplicationFiled: June 12, 2023Publication date: March 21, 2024Applicants: Fujitsu Limited, KEIO UNIVERSITYInventors: Takuya SAKAMOTO, Kazuaki NIMURA, Ryuichi MATSUKURA, Koji NAKAMICHI, Masayuki FUKUI, Shigeya SUZUKI, Osamu NAKAMURA, Ryosuke ABE
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Patent number: 11932679Abstract: The purpose of the present invention is to provide an agent for restoring a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function restoring ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-transporting receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-coupled receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-transporting receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-coupled receptor rhodopsin.Type: GrantFiled: September 1, 2017Date of Patent: March 19, 2024Assignees: Keio University, Nagoya Institute of TechnologyInventors: Toshihide Kurihara, Yusaku Katada, Hiromitsu Kunimi, Kazuo Tsubota, Hideki Kandori
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Publication number: 20240084260Abstract: Provided is a method of culturing a human hepatic parenchymal cell, including culturing a human hepatic parenchymal cell in a medium containing: a culture supernatant of a human hepatic nonparenchymal cell; a Wnt signaling promoter; and a mitogenic growth factor.Type: ApplicationFiled: January 14, 2022Publication date: March 14, 2024Applicant: KEIO UNIVERSITYInventors: Norio MASUDA, Toshiro SATO
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Patent number: 11891621Abstract: Provided is a method of differentiating a pluripotent stem cell of mammalian origin into a desired cell type by predicting the direction of cell differentiation to be caused by induction of expression of a transcription factor. A human gene expression correlation matrix using human cells has been newly created, and further, it has been confirmed that human pluripotent stem cells can be differentiated into a desired cell type by introducing, into the human pluripotent stem cells, a transcription factor cocktail selected from the matrix.Type: GrantFiled: October 8, 2020Date of Patent: February 6, 2024Assignee: KEIO UNIVERSITYInventor: Minoru Ko
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Publication number: 20240034440Abstract: Provided herein are compositions and methods for the induction and/or proliferation of CD8+ T-cells. The disclosure also provides methods of treatment of diseases that can be treated by the induction and/or proliferation of CD8+ T-cells.Type: ApplicationFiled: March 10, 2023Publication date: February 1, 2024Applicants: Keio University, The University of TokyoInventors: Kenya Honda, Takeshi Tanoue, Masahira Hattori, Yutaka Kawakami
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Patent number: 11875832Abstract: Provided are a spintronics device, a magnetic memory, and an electronics device capable of generating a large spin current without depending on a specific material. A spintronics device includes a first conductive layer, a second conductive layer having carrier mobility or electrical conductivity lower than that of the first conductive layer, and a boundary region between the conductive layers. The boundary region has a gradient of carrier mobility or electrical conductivity, and a spin current is generated by rotation of a velocity field of an electron caused by the gradient.Type: GrantFiled: September 4, 2019Date of Patent: January 16, 2024Assignee: KEIO UNIVERSITYInventor: Yukio Nozaki
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Publication number: 20240011973Abstract: A method for producing a two-dimensional small intestinal organoid having a villus structure, the method including a step 1 of culturing a cell derived from a small intestinal epithelium in an extracellular matrix to obtain a three-dimensional small intestinal organoid, a step 2 of dispersing the three-dimensional small intestinal organoid and monolayer culturing on the extracellular matrix to obtain a two-dimensional small intestinal organoid, and a step 3 of further culturing the two-dimensional small intestinal organoid while letting a culture medium of the two-dimensional small intestinal organoid to flow so that the two-dimensional small intestinal organoid forms a villus structure.Type: ApplicationFiled: December 3, 2021Publication date: January 11, 2024Applicants: KEIO UNIVERSITY, JSR CORPORATIONInventors: Toshiro SATO, Shinya SUGIMOTO, Kazuya ARAI
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Patent number: 11867697Abstract: A pancreatic cancer detection method is provided, including: (a) bringing extracellular vesicles, which are in a body fluid sample derived from a subject into contact with one or more kinds of lectins; (b) measuring an amount of the extracellular vesicles bound to the one or more kinds of lectins after (a); and (c) evaluating the presence of pancreatic cancer in the subject based on the amount of the extracellular vesicles measured in (b). In addition, a pancreatic cancer detection kit is provided, including: a solid-phase carrier on which one or more kinds of lectins are immobilized; and an antibody specifically binding to a pan-extracellular vesicle membrane protein or an antigen-binding fragment thereof.Type: GrantFiled: August 17, 2021Date of Patent: January 9, 2024Assignees: JVCKENWOOD CORPORATION, KEIO UNIVERSITYInventors: Makoto Itonaga, Masayuki Ono, Takahiro Yokose, Atsushi Matsuda, Yasuaki Kabe, Sachiko Matsuda, Miwa Hirai, Minoru Kitago
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Patent number: 11859174Abstract: To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.Type: GrantFiled: December 22, 2020Date of Patent: January 2, 2024Assignee: KEIO UNIVERSITYInventors: Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Toshiro Sato, Takanori Kanai
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Publication number: 20230415350Abstract: An information processing device (10) includes: a first acquisition section (12) that acquires input data; a generation section that generates, from the input data, reservoir input data which is to be input to a quantum reservoir (20) having a plurality of layers of sub-reservoirs; a second acquisition section (12) that acquires an output result of the quantum reservoir to which the reservoir input data has been input; and an output data generation section (14) that generates output data with reference to the output result.Type: ApplicationFiled: September 8, 2023Publication date: December 28, 2023Applicants: MITSUBISHI CHEMICAL CORPORATION, KEIO UNIVERSITYInventors: Qi GAO, Ken PRADEL, Naoki YAMAMOTO, Yudai SUZUKI
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Patent number: 11845926Abstract: To identify a microorganism causing the development of primary sclerosing cholangitis associated with ulcerative colitis. A Klebsiella pneumoniae strain inducing inflammation in the liver.Type: GrantFiled: December 22, 2020Date of Patent: December 19, 2023Assignee: KEIO UNIVERSITYInventors: Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Toshiro Sato, Takanori Kanai
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Patent number: 11840738Abstract: A method for determining a risk of urothelial carcinoma may be based on the methylation level of DNA. A method for determining a risk of canceration of a urothelial tissue may involve detecting the DNA methylation level of a CpG site of at least one gene selected from TENM3, HOXC4, TLR1, CPVL and PRDM16 in genomic DNA preferably derived from a urothelial cell or a tissue containing the urothelial cell; and determining a risk of canceration of the urothelial tissue from the detected DNA methylation level.Type: GrantFiled: March 19, 2019Date of Patent: December 12, 2023Assignee: KEIO UNIVERSITYInventors: Yae Kanai, Eri Arai
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Publication number: 20230390459Abstract: The present invention relates to an axon bundle obtained by a method of culturing a nerve cell aggregation having one spheroid and an axon bundle extending from the spheroid wherein the nerve cell aggregation consisting of a plurality of neurons having a cell body and an axon obtained by a method comprising the following step: supplying a culture medium to one first chamber, one second chamber and one channel having the length of at least 1 mm, the width of 100 to 150 ?m and the height of 100 to 200 ?m, which connecting said first chamber and second chamber, wherein said first chamber, second chamber, and channel are contained in one of the modules disposed in a culture plate, seeding the first chamber with a nerve cell derived from a stem cell or a spheroid of primary cultured nerve cells; and culturing said nerve cell, thereby growing an axon bundle from said spheroid and extending them into said channel, wherein the length of the axon bundle obtained is 1 mm or more, and the diameter of the axon bundlesType: ApplicationFiled: October 28, 2021Publication date: December 7, 2023Applicants: KEIO UNIVERSITY, Jiksak Bioengineering Inc.Inventors: Shinsuke SHIBATA, Hiroo KIMURA, Takayuki NISHIJIMA, Tomoko SHINDO, Hideyuki OKANO, Jiro KAWADA, Sayaka TOITA
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Patent number: 11834681Abstract: A cell culture medium for culturing organoid containing at least two types of components selected from the group consisting of insulin-like growth factor 1 (IGH1), fibroblast growth factor 2 (FGF2) and epiregulin (EREG), and at least one type of component among the following components i (to III); i) Wnt agonist, ii) bone morphogenetic protein (BMP) inhibitor, and iii) transforming growth factor-? (TGIF-?) inhibitor.Type: GrantFiled: March 20, 2020Date of Patent: December 5, 2023Assignee: KEIO UNIVERSITYInventors: Toshiro Sato, Mami Matano
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Publication number: 20230374128Abstract: The present invention provides a therapeutic agent for an immune/inflammatory disease comprising an anti-human TIGIT antibody, which activates a suppressive immune checkpoint molecule (TIGIT), as an active ingredient. Also, provided is an antibody having the following characteristics a) and b): a) the third CDR of heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 4 b) the third CDR of light chain variable region comprises the amino acid sequence of SEQ ID NO: 6.Type: ApplicationFiled: October 8, 2021Publication date: November 23, 2023Applicants: Keio University, Takeda Pharmaceutical Company LimitedInventors: Tsutomu TAKEUCHI, Akihiko YOSHIMURA, Katsuya SUZUKI, Masaru TAKESHITA, Marenori KOJIMA, Yoshiaki KASSAI, Taku KORO, Keiko SEKIYA, Tomoki YOSHIHARA, Ryutaro ADACHI