Abstract: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
Type:
Grant
Filed:
October 14, 2015
Date of Patent:
September 27, 2016
Assignee:
KellBenx Inc.
Inventors:
Christiane Hollmann, Silke Zimmermann, Stefan Stachelhaus, Winfried Albert
Abstract: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
Type:
Application
Filed:
October 14, 2015
Publication date:
March 24, 2016
Applicant:
KELLBENX INC.
Inventors:
Christiane HOLLMANN, Silke ZIMMERMANN, Stefan STACHELHAUS, Winfried ALBERT
Abstract: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
Type:
Application
Filed:
August 13, 2015
Publication date:
February 11, 2016
Applicant:
KELLBENX INC.
Inventors:
Christiane HOLLMANN, Silke ZIMMERMANN, Stefan STACHELHAUS, Winfried ALBERT
Abstract: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The inventive monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
Type:
Grant
Filed:
September 16, 2013
Date of Patent:
November 24, 2015
Assignee:
KellBenx Inc.
Inventors:
Christiane Hollmann, Silke Zimmermann, Stefan Stachelhaus, Winfried Albert
Abstract: The invention provides a method for isolating or enriching a rare cell from a biological fluid of a mammal employing an antibody that binds a cell-surface antigen of the rare cell. The immobilized antibody is incubated with a sample of biological fluid that includes the rare cells and a plurality of other cells so as to form an antibody-rare cell complex. The complex can be detected or isolated and subsequently analyzed by any of a variety of physical, chemical and genetic techniques.
Type:
Application
Filed:
August 21, 2014
Publication date:
May 14, 2015
Applicant:
KELLBENX INC.
Inventors:
Javad Khosravi, Leonard H. Kellner, Hassan Bennani
Abstract: The invention provides a method for isolating or enriching a rare cell from a biological fluid of a mammal employing an antibody that binds a cell-surface antigen of the rare cell. The immobilized antibody is incubated with a sample of biological fluid that includes the rare cells and a plurality of other cells so as to form an antibody-rare cell complex. The complex can be detected or isolated and subsequently analyzed by any of a variety of physical, chemical and genetic techniques.
Type:
Application
Filed:
November 14, 2011
Publication date:
May 16, 2013
Applicant:
KELLBENX INC.
Inventors:
Javad Khosravi, Leonard H. Kellner, Hassan Benanni