Abstract: Provided are: a citrus seed extract-containing composition, a food and a drug all of which sufficiently exert a novel function of a citrus (specifically, a citrus seed extract), and a method for producing the citrus seed extract-containing composition. The citrus seed extract-containing composition includes obacunone and nomilin both derived from a citrus seed extract. Herein, the ratio of the obacunone content to the nomilin content (i.e., obacunone content/nomilin content) is at least 0.020.

Abstract: An object of the present invention is to provide a method for efficiently obtaining a lactic bacterium having a high double-stranded RNA content obtained by the method. The object is achieved by: (1) a method for producing a double-stranded RNA-containing lactic acid bacterium, including a step of culturing a lactic acid bacterium under at least one condition of an aeration condition and a low-temperature condition lower than an optimum temperature, thereby obtaining the double-stranded RNA-containing lactic acid bacterium; (2) a double-stranded RNA-containing lactic acid bacterium, in which the content of double-stranded RNA is 2.0 times or more as compared with the content of double stranded RNA when a bacterium of the same strain is cultured for the same culture time under an optimum temperature and non-aeration condition; or the like.

Abstract: Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant.

Abstract: A seed koji (Aspergillus starter) for brewing is provided. The seed koji is obtained by inoculating koji mold(s) belonging to an Aspergillus genus into a seed koji raw material, where the seed koji raw material is a pea.

Abstract: The problem to be solved by the present invention is to provide a method of producing isoprenoids including ascofuranone, ilicicolin A, and ascochlorin and derivatives thereof in a high yield as compared to the conventional art, which method enables industrial-scale production of isoprenoids. The problem can be solved by a method of producing isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin, including using a transformant obtained by transformation with biosynthetic genes for ascofuranone, ilicicolin A, or ascochlorin or a knockout organism for these genes to obtain isoprenoids such as ascofuranone, ilicicolin A, and ascochlorin.

Abstract: Provided are a kit and a method for measuring cleanliness of a bio-related sample and a bio-related instrument, which is not susceptible to ATP-degrading activity. Provided are a method for measuring cleanliness of a bio-related sample or a bio-related instrument and a kit therefor, comprising using an enzyme that catalyzes a reaction that produces ATP from ADP, luciferin, luciferase, and a metal salt. Also provided are a method further comprising using pyruvate orthophosphate dikinase (PPDK), adenylate kinase (ADK), or pyruvate-water dikinase (PWDK) and a kit further comprising PPDK, ADK, or PWDK. Further provided are a method for measuring cleanliness of a bio-related sample or a bio-related instrument and a kit therefor, comprising using an enzyme that catalyzes a reaction that produces ATP from AMP, an enzyme that catalyzes a reaction that produces AMP from ADP, luciferin, luciferase, and a metal salt.

Abstract: A cap includes a main unit fit onto the mouth of a double-walled container, a spout cylinder provided on the main unit, an inner stopper that is provided in the main unit, and a first inner valve. The inner stopper includes a communicating part that communicates with the inside of the inner container and the inside of the spout cylinder. The first inner valve includes a first valve body that covers the communicating part. The first valve body has passage holes. The first valve body being deformed from a closing position S toward an opening position O keeps acting as a partition between the communicating part and the spout cylinder.

Abstract: Provided is a compound which accelerates the enzymatic reaction catalyzed by an oxidase. The present invention provides an oxidase reaction accelerating agent comprising a compound represented by formula (I) and a method using the same.

Abstract: Provided is a compound capable of accelerating the enzymatic reaction catalyzed by peroxidase. The present invention provides a peroxidase reaction accelerating agent comprising a compound represented by formula (I) and a method for measuring hydrogen peroxide using the same.

Abstract: This invention provides an improved method for electrochemical glucose measurement and an improved composition for glucose measurement. This invention also provides a composition for glucose measurement comprising a flavin compound. This invention also provides an electrode comprising a flavin compound and a sensor and a glucose fuel cell comprising such electrode. In addition, this invention provides a method for electrochemical glucose measurement and a method for electric power generation using a flavin compound. The flavin compound of the present invention is non-toxic or less toxic and it can be thus used for a means of self-contained continuous glucose measurement.

Abstract: A cap includes a main unit fit onto the mouth of a double-walled container, a spout cylinder provided on the main unit, an inner stopper that is provided in the main unit, and a first inner valve. The inner stopper includes a communicating part that communicates with the inside of the inner container and the inside of the spout cylinder. The first inner valve includes a first valve body that covers the communicating part. The first valve body has passage holes. The first valve body being deformed from a closing position S toward an opening position O keeps acting as a partition between the communicating part and the spout cylinder.

Abstract: To reduce the effect of L-proline in the reaction of a sarcosine oxidase. A modified sarcosine oxidase having reduced reactivity to L-proline is provided.

Abstract: Provided is a method of continuous glucose monitoring (CGM) comprising using an FAD-GDH. The FAD-GDH is capable of retaining initial activity over a certain period of time. Also provided is a method for screening for an FAD-GDH suitable for use in CGM as well as a CGM device comprising an FAD-GDH.

Abstract: A cap includes a main unit fit onto the mouth of a double-walled container, a spout cylinder provided on the main unit, an inner stopper that is provided in the main unit, and a first inner valve. The inner stopper includes a communicating part that communicates with the inside of the inner container and the inside of the spout cylinder. The first inner valve includes a first valve body that covers the communicating part. The first valve body has passage holes. The first valve body being deformed from a closing position S toward an opening position O keeps acting as a partition between the communicating part and the spout cylinder.