Abstract: A method of regulating body temperature that involves (i) determining, via processing circuitry, if sensor data from a plurality of sensors is in a predetermined normal range, (ii) converting the sensor data to fuzzy values when the sensor data is not in the predetermined normal range, (iii) combining one or more related consequents of the predetermined fuzzy rules, (iv) evaluating the combined consequents to determine a centroid value using a centroid method; and (v) transmitting the centroid value to a thermal management system to activate the thermal management system to a predetermined activation level based on the centroid value, wherein the plurality of sensors include a core temperature sensor, a skin temperature sensor, a skin blood flow sensor, a cardiac output sensor, a neuromuscular activity output sensor, an electromyography sensor, a vibration sensor, and an imaging device.

Abstract: A biocompatible curable composition and a method of detecting a border of a tumor, a tissue of interest, or both including injecting the biocompatible curable composition and contacting the border of a tumor or a tissue, the biocompatible curable composition crosslinks to form a three-dimensional cured nanocomposite, and imaging the three-dimensional (3D) cured nanocomposite, and imaging the 3D cured nanocomposite by at least one of MRI, CT, ultrasound, and X-ray, to detect the border of the tumor or the tissue of interest or track tumor motion during radiotherapy treatment. The biocompatible curable composition comprising an organic polymer having a hydrolysable functional group, a metallic nanoparticle, and a polar or a non-polar solvent. A brachytherapy strand consisting of a biocompatible curable composition and a radio-isotope seed. The biocompatible curable composition is shaped into an elongated cylinder and forms a 3D cured nanocomposite with a radio-isotope seed embedded.

Abstract: A method is described for exfoliating a microcrystal of an anthracene derivative by irradiation with short pulses of light having a wavelength of 220-420 nm. The irradiation induces a cis-trans isomerization of the anthracene derivative in a part of the microcrystal, which leads to the separation of an outer layer having a thickness of 200-600 nm. The exfoliated microcrystal may be irradiated again with pulses of light of a same or different wavelength.

Abstract: A method of treating leukemia in a patient, the method including obtaining a plasma sample from a patient at a first time point and at a second time point, measuring a gene expression level of a set of core clock genes, and at least one of a first set of peripheral clock genes and a second set of peripheral clock genes, each in the plasma sample at the first time point and in the plasma sample at the second time point. Then determining that a first treatment is effective or ineffective for the patient when a correlation of the gene expression level of the set of core clock genes, the first set of peripheral clock genes, and the second set of peripheral clock genes, and treating the patient accordingly.

Abstract: A method of regulating body temperature that involves (i) determining, via processing circuitry, if sensor data from a plurality of sensors is in a predetermined normal range, (ii) converting the sensor data to fuzzy values when the sensor data is not in the predetermined normal range, (iii) combining one or more related consequents of the predetermined fuzzy rules, (iv) evaluating the combined consequents to determine a centroid value using a centroid method; and (v) transmitting the centroid value to a thermal management system to activate the thermal management system to a predetermined activation level based on the centroid value, wherein the plurality of sensors include a core temperature sensor, a skin temperature sensor, a skin blood flow sensor, a cardiac output sensor, a neuromuscular activity output sensor, an electromyography sensor, a vibration sensor, and an imaging device.

Abstract: A skull-implantable magnet assembly for delivering a static magnetic field to a patient's brain, comprising a rod-shaped magnet housed within a skull screw, removably attached to a casing housing at least one flat magnet, is described. Details of the exterior construction are discussed, as well as magnet arrangements and methods of treating a brain tumor or neurological ailment of a patient.

Abstract: An artificial hypothalamus system for regulating body temperature for a human can include monitoring data from a plurality of sensors. The sensor data can be used in a control system to optimize temperature regulation in real time through a feedback loop. The feedback loop can include monitoring the sensor data, evaluating a predetermined set of fuzzy rules using the data, and combining the output of the fuzzy rules to produce a precise value. The precise value can correspond to an output level for various temperature regulation devices, and a signal can be transmitted based on the precise value to activate the temperature regulation devices to a corresponding level of output.

Abstract: This disclosure relates to a cartilage prosthetic implant that can be used in orthopedics for a replacement of a damaged cartilage in a joint between opposing bones, for example in the case of osteoarthritis or trauma. The cartilage prosthetic implant described herein can replace the damaged cartilage at the joint without cutting bones of the joint. The cartilage prosthetic implant can maintain or restore a native joint anatomy, allowing for a natural movement at the joint. The cartilage prosthetic implant can be used as a permanent treatment or an intermediate treatment before requiring a total joint replacement. An example of the cartilage prosthetic implant is described for a knee joint replacement and is divided into a proximal implant configured to replace a cartilage at a distal end of a femur bone and a distal implant configured to replace a cartilage on a proximal end of a tibia bone.

Abstract: A method is described for exfoliating a microcrystal of an anthracene derivative by irradiation with short pulses of light having a wavelength of 220-420 nm. The irradiation induces a cis-trans isomerization of the anthracene derivative in a part of the microcrystal, which leads to the separation of an outer layer having a thickness of 200-600 nm. The exfoliated microcrystal may be irradiated again with pulses of light of a same or different wavelength.

Abstract: A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising a conductor housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient.

Abstract: A method for detecting cancer by determining ratios of alternatively spliced Lamin A/C gene mRNAs in tissue samples, especially an increased ratio of Lamin C to Lamin A mRNAs. Therapeutic for subjects having a tumor or cancer characterized by an elevated ratio of Lamin C to Lamin A mRNA or protein.

Abstract: The present disclosure relates to methods of reducing the number of abnormal PBMC cells in a leukemia patient. The methods may include administering an effective amount of a drug, which may not be indicated for leukemia, or an antibody-drug conjugate. The antibody-drug conjugate includes an antibody selected from the group consisting of an anti-?2-adrenoreceptor antibody, an anti-? adrenoceptor antibody, an anti-trace amine-associated receptor 1 antibody, an anti-dopamine receptor antibody, and an anti-serotonin receptor antibody; a drug selected from the group consisting of isoproterenol, methyldopa, olanzapine, and a derivative thereof; and a linker that conjugates the antibody and the drug.

Abstract: A nanoparticle that has a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, a targeting group attached to the outside of the nanoparticle, and a breast cancer therapeutic agent that is encapsulated by the membrane. A nanoparticle that consists of a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, breast cancer therapeutic agent that is encapsulated by the membrane, and an anti-Her2 antibody attached to the outer surface of the nanoparticle. A range of a number average molecular weight of the PEG block is 800 Da to 3 kDa and a range of a number average molecular weight of each of the PLA blocks is from 1 kDa to 5 kDa.

Abstract: A real-time analyte sensing device that can be connected to a-peritoneal catheter having a first flexible tube, a second flexible tube, connected to a 3-way port and including an analyte sensor connected to a sensor wire at one end by a sensor connector. The sensor wire has a second end that is a data connector. The analyte sensor is connected to the peritoneal catheter via an anti-reflux valve in a third port of the 3-way port. This disclosure further describes a method of changing a dialysis protocol in a patient undergoing peritoneal dialysis. The method includes connecting the sensor device to an intraperitoneal catheter in the patient and connecting the data connector of the device to circuitry that is configured to analyze data received from the analyte sensor and determining a change to the dialysis protocol, and changing the dialysis protocol based on the data received from the analyte sensor.

Abstract: A device for in vivo detecting and quantifying a concentration of an analyte in a peritoneal fluid of a subject. The device includes (a) a catheter having an open proximal end configured to be disposed external to the subject, an open distal end configured to be disposed within the peritoneal cavity comprising the peritoneal fluid, an anchor portion, an outer wall, and an inner wall, (b) a sensor disposed adjacent to the open distal end and configured to detect and quantify the concentration of the analyte in the peritoneal fluid, and (c) a main control unit disposed external to the subject, connected to the sensor via a wire, and configured to control the sensor, receive and store detection and quantification data from the sensor, and transmit the data to a second device. A portion of the wire is disposed between the inner wall and the outer wall of the catheter.

Abstract: A stopper is provided for preventing blockage of a cannula of an intravenous catheter in-between uses including a hub having a connector for securing to the catheter, and a stylet having a length and a shape configured to fill a lumen of the cannula, where the hub is configured to place the stylet within the lumen of the cannula, and where the stylet is configured to prevent blood from clotting within the lumen of the cannula when inserted in a patient between uses. In some implementations, the stopper can have a movable stylet. In an example, the stylet can have a variable stiffness configured to aid in moving and prevent blockage of the lumen by kinking of the cannula.

Abstract: A system and method are provided for early recognition and escalating provider notification for an insidious medical condition. The method includes: setting, based on a patient clinical assignment, an escalating alert criteria including a set of diagnosis parameters and an alert timing; searching a patient record having a set of patient data for the escalating alert criteria; assigning a provider assignment based on the patient clinical assignment and the escalating alert criteria; creating an escalating alert procedure based on at least one of the patient clinical assignment, the provider assignment, the set of patient data, and the escalating alert criteria; sending a notification to at least one communication system in communication with a notification device based on the provider assignment; receiving a medical order in response to the notification; and modifying at least one of the set of diagnosis parameters and the alert timing based on the medical order.

Abstract: A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising an electrode housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient.

Abstract: A cannula apparatus including an outer tube with an elongated body and a groove, an inner tube disposed inside the outer tube and being manipulable through the groove, and a cap including a hole, the cap mounted at one end of the outer tube through the hole, in which the inner tube is freely slidable relative to the outer tube.

Abstract: A skull-implantable magnet assembly for delivering a static magnetic field to a patient's brain, comprising a rod-shaped magnet housed within a skull screw, removably attached to a casing housing at least one flat magnet, is described. Details of the exterior construction are discussed, as well as magnet arrangements and methods of treating a brain tumor or neurological ailment of a patient.