Abstract: The present invention is directed to methods for preventing crystal growth and particle aggregation in nanoparticulate compositions. The methods comprise reducing a nanoparticulate composition to an optimal effective average particle size. The resultant nanoparticulate compositions exhibit prolonged particle size stability and minimal crystal growth, even following exposure to elevated temperatures.
Type:
Grant
Filed:
March 8, 1999
Date of Patent:
July 31, 2001
Assignee:
Klan Pharma International Ltd.
Inventors:
Elaine Liversidge, Greta A. Gottardy, Linden Wei