Abstract: Patients suffering from certain types of cancer are treated by high-dose chemotherapy. In order to allow a recovery a process for the ex vivo expansion of peripheral blood progenitor cells is described, wherein CD 34.sup.+ -cells are enriched and cultivated in a medium comprising IL-1, IL-3, IL-6, EPO and SCF. The ex vivo expanded peripheral blood progenitor cells can be administered to cancer patients after chemotherapy.
Type:
Grant
Filed:
September 29, 1993
Date of Patent:
December 5, 1995
Assignee:
Klinkum der Albert-Ludwigs-Universitat Freiberg
Inventors:
Lothar Kanz, Woefram Brugger, Roland Mestepsmann