Patents Assigned to Koichi Shudo
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Patent number: 7045516Abstract: A compound represented by the following general formula (1): wherein R1 represents a halogen atom, R2 represents hydrogen atom or a lower alkyl group, and R3 represents hydrogen atom, a lower alkyl group, a lower alkoxyl group, a hydroxy lower alkyl group, a halogen atom, or a substituted or unsubstituted amino group, wherein a substituent on the amino group is selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkylcarbonyl group, and an amino protective group, or a salt thereof. The compound of the present invention or a salt thereof is useful as an active ingredient of medicaments for preventive and/or therapeutic treatment of conditions of irritable bowel syndrome and digestive tract functional disorder, or condition of diarrhea.Type: GrantFiled: November 19, 1999Date of Patent: May 16, 2006Assignee: Koichi ShudoInventors: Sojiro Shiokawa, Yasuo Sato, Masaaki Izumi, Satoshi Yoshida, Tomoko Ito, Tetsutaro Niisato, Hiroshi Murakami
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Patent number: 6333328Abstract: This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators.Type: GrantFiled: October 12, 2000Date of Patent: December 25, 2001Assignees: Meiji Seika Kaisha, Ltd., Koichi ShudoInventors: Yasuo Sato, Megumi Yamada, Kazuko Kobayashi, Katsuyoshi Iwamatsu, Fukio Konno, Koichi Shudo
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Patent number: 6037342Abstract: This invention provides a serotonin 5-HT.sub.3 receptor partial activator which has a serotonin 5-HT.sub.3 receptor activating action, in addition to its serotonin 5-HT.sub.3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT.sub.3 receptor antagonism and serotonin 5-HT.sub.3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT.sub.3 receptor partial activators. ##STR1## In the above formula, R.sub.1 to R.sub.4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R.sub.1 and R.sub.2 may be linked together to form a ring structure, namely benzene ring; R.sub.Type: GrantFiled: May 6, 1997Date of Patent: March 14, 2000Assignees: Meiji Seika Kaisha, Ltd, Koichi ShudoInventors: Yasuo Sato, Megumi Yamada, Kazuko Kobayashi, Katsuyoshi Iwamatsu, Fukio Konno, Koichi Shudo
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Patent number: 5767146Abstract: An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (Ill): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.Type: GrantFiled: September 22, 1997Date of Patent: June 16, 1998Assignees: Hoechst Japan Limited, Koichi ShudoInventors: Koichi Shudo, Tatsuo Sugioka, Mizuho Inazu, Hideyuki Tanaka, Tsutomu Inoue, Kazuyuki Kitamura
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Patent number: 5719180Abstract: Described herein is a chroman derivative represented by the following formula: ##STR1## wherein X represents H, --CH.sub.2 OH, --CHO, --COOH, --COOCH.sub.3, --CH.dbd.NOH, --CONH.sub.2, --COCH.sub.3, --CH(OH)CH.sub.3, Br, or CN; Y represents a hydroxyl group which may optionally be protected; R represents an alkyl group, alkenyl group, or aralkyl group; provided that, where X is hydrogen atom, R is an alkyl group, alkenyl group, or aralkyl group each having 16 or more carbon atoms; and a vitamin E-like active medicament comprising said derivative as an active ingredient.Type: GrantFiled: August 12, 1996Date of Patent: February 17, 1998Assignee: Koichi ShudoInventors: Koichi Shudo, Masashi Akaike
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Patent number: 5716995Abstract: An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.Type: GrantFiled: June 7, 1995Date of Patent: February 10, 1998Assignees: Hoechst Japan Limited, Koichi ShudoInventors: Koichi Shudo, Tatsuo Sugioka, Mizuho Inazu, Hideyuki Tanaka, Tsutomu Inoue, Kazuyuki Kitamura
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Patent number: 5703128Abstract: An anti-osteopathic composition comprising as an active ingredient a compound represented by the following formula (I), (II) or (III): ##STR1## which is useful for therapeutic and prophylactic treatment of osteopathia such as osteoporosis and bone fracture.Type: GrantFiled: March 8, 1996Date of Patent: December 30, 1997Assignees: Hoechst Japan Limited, Koichi ShudoInventors: Koichi Shudo, Tatsuo Sugioka, Mizuho Inazu, Hideyuki Tanaka, Tsutomu Inoue, Kazuyuki Kitamura
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Patent number: 5652232Abstract: A benzolactam derivative represented by the following formula (I): ##STR1## wherein n represents an integer of from 1 to 3; R.sup.1 represents a straight- or branched-chain alkyl group or an aralkyl group; R.sup.2 represents a straight- or branched-chain alkyl group; R.sup.3 and R.sup.4 independently represent a hydrogen atom or a straight- or branched-chain alkyl group, and when R.sup.3 and R.sup.4 are adjacent each other on the phenyl group, they may be combined to form a cycloalkyl ring together with two carbon atoms of the phenyl group to which R.sup.3 and R.sup.4 bind, and said cycloalkyl ring may optionally have one or more substituents; and a anti-retroviral agent comprising the same as an active ingredient.Type: GrantFiled: May 24, 1996Date of Patent: July 29, 1997Assignees: Shionogi & Co., Ltd., Koichi ShudoInventors: Koichi Shudo, Yasuyuki Endo, Tamio Fujiwara, Akihiko Sato
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Patent number: 5631257Abstract: A benzoxazole derivative of the formula (1) or (2) which has an alicyclic diamine group at the 2-position: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X.sup.-, m and n are defined herein. The compound shows excellent 5-HT.sub.3 receptor antagonism and is useful as an antiemetic agent, a peristalsis controlling agent, an analgesic agent, an antianxiety agent and a schizophrenia treating agent.Type: GrantFiled: June 7, 1995Date of Patent: May 20, 1997Assignees: Meiji Seika Kaisha, Ltd., Koichi ShudoInventors: Katsuyoshi Iwamatsu, Yasuo Sato, Masaaki Izumi, Fukio Konno, Seiji Shibahara, Shigeharu Inoye, Koichi Shudo, Kazuko Amano
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Patent number: 5420145Abstract: Carboxylic acid derivatives having potent retinoid-type pharmacological activities are disclosed. The compounds disclosed are represented by the following formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent a hydrogen atom or an alkyl group with the exception that all of R.sup.1, R.sup.2, and R.sup.3 do not simultaneously represent hydrogen atoms and R.sup.1 together with R.sup.2 optionally represent a cyclic structure formed by the combination thereof; R.sup.4 represents a hydrogen atom or an alkyl group; X represents a nitrogen atom or C--OH; and A represents --CO--NH-- or --NH--CO--.Type: GrantFiled: March 23, 1993Date of Patent: May 30, 1995Assignees: Koichi Shudo, Shionogi Pharmaceutical Co., Ltd.Inventor: Koichi Shudo
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Patent number: 4703110Abstract: The application discloses certain benzoic acid compounds, the same being more adequately described as benzoic acid derivatives having a para substituent which is a substituted phenyl radical attached to the benzoic acid in the para position by any one of a variety of linking groups, representative compounds being p-(3,4-diisopropylphenylcarbamoyl) benzoic acid and p-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylcarbamoyl)benzoic acid, pharmaceutical compositions thereof, method of treating therewith, method of diagnosis therewith, and method for the preparation thereof. The compounds and compositions are useful for diagnosis of leukemia types, the treatment of dermatological disorders, and as differentiation-inducing agents for neoplastic cells.Type: GrantFiled: July 8, 1985Date of Patent: October 27, 1987Assignee: Koichi ShudoInventor: Koichi Shudo
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Patent number: 4397678Abstract: Plant growth regulators of the N-(4-pyridazinyl)urea and thiourea type are disclosed which exhibit excellent cytokinin-like activities and are useful for regulating plant growth in various manners, such as acceleration and suppression.Type: GrantFiled: January 27, 1982Date of Patent: August 9, 1983Assignees: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Susumu SatoInventors: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Soshiro Takahashi
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Patent number: 4331807Abstract: Plant growth regulators of the N-(4-pyridazinyl)urea and thiourea type are disclosed which exhibit excellent cytokinin-like activities and are useful for regulating plant growth in various manners, such as acceleration and suppression.Type: GrantFiled: May 30, 1980Date of Patent: May 25, 1982Assignees: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Susumu SatoInventors: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Soshiro Takahashi
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Patent number: 4279639Abstract: Plant growth and suppression regulators of the N-(2-substituted-4-pyridyl)urea and thiourea type are provided, which exhibit excellent cytokinin-like activities and are thus useful for regulating plant growth in various fashions, such as acceleration of growth when used in flowering or fruiting at a controlled time when used in small amounts, and controlling compositions such as sugar, alkaloids, etc. of plants, or suppression of plant growth when used in an amount higher than optimal for growth acceleration, etc.Type: GrantFiled: August 1, 1979Date of Patent: July 21, 1981Assignees: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Susumu SatoInventors: Toshihiko Okamoto, Yo Isogai, Koichi Shudo, Soshiro Takahashi
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Patent number: RE31550Abstract: N-(2-Chloro-4-pyridyl)ureas represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or alkyl, R.sub.2 represents an aromatic group, especially phenyl, which may be substituted by alkyl, alkoxyl, hydroxyl or halogen, and X is oxygen or sulfur, and acid addition salts thereof, useful as plant growth regulators, are disclosed. Method of making and using same and agricultural compositions thereof are also disclosed.Type: GrantFiled: September 25, 1981Date of Patent: April 10, 1984Assignees: Koichi Shudo, Toshihiko Okamoto, Yo Isogai, Soshiro TakahashiInventors: Koichi Shudo, Toshihiko Okamoto, Yo Isogai, Soshiro Takahashi