Patents Assigned to Koken Co Ltd
  • Publication number: 20080301823
    Abstract: As novel means for causing any recombinant protein produced by the silkworm middle silk gland to be secreted in cocoons and easily extracting the recombinant protein from the cocoons without modification of the conformation of the protein, there is provided a polynucleotide that in an expression cassette for expression of a recombinant protein by the silkworm middle silk gland, is functionally linked to a recombinant protein structure gene, which polynucleotide is one composed of a polynucleotide constructing the promoter regions of sericin 1 or sericin 2 gene and, functionally linked thereto, a polynucleotide constructing the homologous regions of baculovirus.
    Type: Application
    Filed: October 14, 2005
    Publication date: December 4, 2008
    Applicants: HIROSHIMA INDUSTRIAL PROMOTION ORGANIZATION, BIOINTEGRENCE INC., KOKEN CO., LTD.
    Inventors: Masahiro Tomita, Katsuhiko Shimizu, Shingo Ogawa, Rika Hino, Masashi Iizuka, Takahiro Adachi, Katsutoshi Yoshizato
  • Patent number: 7052875
    Abstract: The invention is directed to the retention of the stability of formulations useful for a gene therapy during the preparation and preservation. In the invention, at least one saccharide and/or at least one non-hydrophobic amino acid and/or at least one organic acid having two or more carboxyl groups except amino acids, or a collagen or a gelatin and at least one amino acid are added to a gene formulation.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: May 30, 2006
    Assignees: Sumitomo Pharmaceutical Company, Limited, Koken Co., Ltd.
    Inventors: Masaaki Terada, Takahiro Ochiya, Akihiko Sano, Akihiko Hisada, Shunji Nagahara
  • Patent number: 7018359
    Abstract: The present invention is an inner pressure indicator of a cuff comprising, a housing possessing on one end an opening that can connect to a cuff inflating tube of a tracheostomy tube with a cuff or of an endotracheal tube and on the other end of said housing possessing an opening to which a valve that prevents the reduction of inner pressure is equipped with, said housing is characterized by being equipped with an inner pressure indicating device of cuff and also the inner pressure of the cuff can be regulated by said opening with a valve by way of said inner pressure indicating device of the cuff.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: March 28, 2006
    Assignee: Koken Co., Ltd.
    Inventors: Daisuke Igarashi, Akira Sato, Takeshi Ohgawara
  • Patent number: 6998268
    Abstract: The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same. The carrier is preferably a soluble collagen such as atelocollagen and may further include an additive. The invention also encompasses methods for delivering genes to cells employing the gene preparation.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: February 14, 2006
    Assignees: Dainippon Sumitomo Pharma Co. Ltd., Koken Co., Ltd.
    Inventors: Masaaki Terada, Takahiro Ochiya, Teruo Miyata, Hiroshi Itoh
  • Patent number: 6966538
    Abstract: A gate valve has a valve rod equipped with a valve plate having a pair of valve plate surfaces, wherein the valve rod is tilted by an actuator to thereby effect highly reliable valve opening/closing operation with a simple construction. In the gate valve, the valve rod, which is equipped with the valve plate with the pair of valve plate surfaces, is rotatably supported, and raised and lowered by a raising/lowering cylinder, the valve rod being tilted by an actuator, a combination of a cam member and a cam raising/lowering cylinder, a combination of a driving block and a cylinder, or a combination of a connection member and a driving device (not shown) to thereby effect valve opening/closing with the pair of valve plate surfaces.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: November 22, 2005
    Assignee: Irie Koken Co., Ltd.
    Inventors: Yuzo Hayashi, Tatsuo Saito, Manabu Yabe, Masaharu Nakagawa
  • Patent number: 6701475
    Abstract: A boundary scan element includes a plurality of input terminal side boundary cells connected in series; a plurality of output terminal side boundary cells connected in series; a TAP circuit for controlling input/output of data to/from the boundary cells on the input/output terminal sides; a TDI terminal for receiving serial data to be supplied to the boundary cells; a TDO terminal for outputting the data from the boundary cells as serial data; a TCK terminal for receiving clock signals; and a TMS terminal for receiving a mode signal to switch an operation mode of the TAP circuit, wherein the boundary cells on the input/output terminal sides are connected in parallel between the TDI and TDO terminals, respectively, and wherein two sets of combinations composed of the input terminal side boundary cells, the output terminal boundary cells, the TDI terminal, the TDO terminal and the TAP circuit are provided.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: March 2, 2004
    Assignees: Koken Co. Ltd.
    Inventor: Mitsugu Nagoya
  • Patent number: 6669711
    Abstract: A surgical balloon which is provided with a plurality of balloons so that a fixing property and a shielding property are simultaneously satisfied, and prevents a liquid or a gas from flowing from one area in the body to another area thereof. The surgical balloon is further provided with a balloon fixing device, a drain for draining water from the front nostril and a tube for supplying rinsing water into the nasal cavity so that a surgical operation using an endoscope is carried out inside the nasal cavity with the nasal cavity filled with a water flow. A high-pressure balloon having a fixing property and a low-pressure balloon having a shielding property are combined, and the balloon is pulled from the periphery of the front nostril so as to be secured; thus, a large amount of water supply and water drain are carried out through the front nostril.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: December 30, 2003
    Assignee: Koken Co. Ltd.
    Inventor: Kazuhiro Noda
  • Patent number: 6671840
    Abstract: A communication system includes boundary scan elements each having a plurality of boundary cells individually assigned to respective input terminals and output terminals, a TAP circuit for controlling input and output of data, a TDI terminal and TDO terminal for inputting or outputting serial data, a TCK terminal to which a clock signal is input, and a TMS terminal to which a mode signal for switching the operation mode is input; a plurality of terminal units connected with the respective boundary scan elements; and a communication controller connected in series with the boundary scan elements for individual control of the terminal units. Incoming communication lines between the boundary scan elements adjoining each other, and between the boundary scan elements and the communication controller, and an outgoing communication line between the communication controller and the boundary scan element positioned at the backmost are formed.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: December 30, 2003
    Assignees: Koken Co., Ltd.
    Inventor: Mitsugu Nagoya
  • Patent number: 6658614
    Abstract: There are provided a boundary scan element including a plurality of input-terminal-side boundary cells connected in series and assigned individually to respective input terminals, a plurality of output-terminal-side boundary cells connected in series and assigned individually to respective output terminals, a TAP circuit for controlling input and output of data to or from the input-terminal-side and output-terminal-side boundary cells, a TDI terminal for inputting serial data to be provided to the boundary cells, a TDO terminal for outputting data from the boundary cells as serial data, a TCK terminal to which a clock signal is input, and a TMS terminal to which a mode signal is input to switch an operation mode of the TAP circuit, characterized in that the input-terminal-side boundary cells and the output-terminal-side boundary cells are connected in parallel between the TDI terminal and the TDO terminal; and a communication system using the same.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: December 2, 2003
    Assignees: Koken Co., Ltd.
    Inventor: Mitsugu Nagoya
  • Publication number: 20030185728
    Abstract: A system for decomposing a liquid or gaseous organic compound comprises a ultraviolet decomposition unit and an intermediate product treatment apparatus. The ultraviolet decomposition unit decomposes an organic compound contained in polluted liquid or polluted gas by irradiating ultraviolet rays whose wavelength is less than 300 nm to the polluted liquid or the polluted gas containing the organic compound. An acid electrolytic water feed pipe and an alkali electrolytic water feed pipe are respectively connected to the intermediate product treatment apparatus through valves to neutralize an intermediate product, which results from decomposition of the organic compound, for decomposition by selectively adding strong alkali electrolytic water and strong acid electrolytic water to the polluted liquid or the polluted gas containing the intermediate product.
    Type: Application
    Filed: March 27, 2003
    Publication date: October 2, 2003
    Applicant: Koken Co.,Ltd.
    Inventors: Kazushi Kimura, Tomoyuki Naito, Takahiro Terajima, Takako Nakatou, Kozo Nitta, Shinji Noguchi
  • Patent number: 6622262
    Abstract: A fault tolerant computer system is provided which can immediately detect that its main computer is down and which can accurately pinpoint the point where the processing is suspended, without delaying the processing which the computer should originally execute. The fault tolerant computer system has: the main computer; an auxiliary computer for normally virtually executing the same processing as that executed by the main computer; a communication element connected to an object, the communication element being a boundary scan element; and a switch unit for switching connection between the communication element and either the main computer or the auxiliary computer. The switch unit switches the connection in accordance with the presence or absence of a clock signal supplied from the main computer to the communication element.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: September 16, 2003
    Assignee: Koken Co., Ltd.
    Inventor: Mitsugu Nagoya
  • Patent number: 6561483
    Abstract: A gate valve according to the present invention including a first valve plate having a valve opening and a second valve plate connected to the first valve plate via a first bellows, in which the rigidity and the like of the valve plates, a valve rod, and the like can be reduced as compared to that in a conventional art by canceling the differential pressure.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: May 13, 2003
    Assignee: Irie Koken Co., Ltd.
    Inventor: Masaharu Nakagawa
  • Patent number: 6561484
    Abstract: A gate valve according to the present invention including a first valve plate having a valve opening, a second valve plate connected to the first valve plate via first bellows, and an actuator provided between the first valve plate and the second valve plate, wherein the first valve plate is moved by the operation of the actuator, thereby enabling the valve plate, a valve rod, and the like to be made small and lightweight.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: May 13, 2003
    Assignee: Irie Koken Co., Ltd.
    Inventors: Masaharu Nakagawa, Hiroshi Minamoto, Manabu Yabe, Yuuzou Hayashi, Norikimi Irie
  • Patent number: 6514614
    Abstract: The present invention is a coated nucleus for a cultured pearl whose surface is coated with water soluble polymer, characterizing over 25% of total coated amount of said water soluble polymer is dissolved by soaking said coated nucleus into seawater of 15° C. temperature for 30 minutes.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: February 4, 2003
    Assignee: Koken Co. Ltd
    Inventors: Hiroshi Komatsu, Hiroshi Ito
  • Publication number: 20020074534
    Abstract: A gate valve according to the present invention comprises a first valve plate having a valve openings, a second valve plate connected to the first valve plate via first bellows, and an actuator provided between the first valve plate and the second valve plate, wherein the first valve plate is moved by the operation of the actuator, thereby enabling the valve plate, a valve rod, and the like to be made small and lightweight.
    Type: Application
    Filed: September 28, 2001
    Publication date: June 20, 2002
    Applicant: IRIE KOKEN CO., LTD.
    Inventors: Masaharu Nakagawa, Hiroshi Minamoto, Manabu Yabe, Yuuzou Hayashi, Norikimi Irie
  • Publication number: 20020066877
    Abstract: A gate valve according to the present invention comprises a first valve plate having a valve opening and a second valve plate connected to the first valve plate via a first bellows, in which the rigidity and the like of the valve plates, a valve rod, and the like can be reduced as compared to that in a conventional art by canceling the differential pressure.
    Type: Application
    Filed: June 11, 2001
    Publication date: June 6, 2002
    Applicant: IRIE KOKEN CO., LTD.
    Inventor: Masaharu Nakagawa
  • Publication number: 20010053839
    Abstract: Disclosed is a chemically crosslinked material, comprising a natural material or a derivative thereof having crosslinks formed by the combination of a primary crosslinking agent and an enhancer compound, wherein the crosslinks formed comprise crosslinks which include at least one additional hydroxyl group and/or at least one additional linear ether linkage as compared to crosslinks formed by the primary crosslinking agent alone. The materials according to preferred embodiments of the invention provide a chemically crosslinked material that has favorable antigenicity/flexibility characteristics.
    Type: Application
    Filed: June 12, 2001
    Publication date: December 20, 2001
    Applicant: KOKEN CO. LTD.
    Inventors: Yasuharu Noishiki, Teruo Miyata, Hiroshi Ito
  • Patent number: 6177544
    Abstract: An auxiliary agent for ophthalmic surgery is based on collagen and, after the completion of surgery, undergoes a lowering in viscosity, and thus can be easily removed. This agent is a neutral solution of collagen which is transparent at a neutral pH and has a denaturation temperature below the intraocular temperature, or a derivative thereof. The agent has a visual light transmission at 400 nm of at least 90% of that before the denaturation, when solution is heated to cause denaturation.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: January 23, 2001
    Assignees: Koken Co Ltd, Japan Science & Technology Corporation
    Inventors: Atsushi Kanai, Teruo Miyata, Hiroshi Itoh, Akiko Tanaka
  • Patent number: 6082706
    Abstract: A non-sliding vacuum gate valve according to the present invention has a curved cam lead member provided to end of a valve rod, and a pair of rollers provided to a connection rod. The cam lead member and the rollers are engaged with each other and move relatively, so that vertical movement and slant movement of a valve plate and the valve rod are guided.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: July 4, 2000
    Assignee: Irie Koken Co., Ltd.
    Inventor: Norikimi Irie
  • Patent number: 6018606
    Abstract: A fiber fixing device for a linear lightguide comprises a tubular chuck and an elastic tubular body. The chuck includes a hollow part along its axis for receiving an optical fiber, a grasp part for grasping the received optical fiber, and a coupling part supporting the grasp part. The elastic tubular body is elastically expanded outwardly in the radial direction and in this state is fitted onto the grasp part of the chuck. Thus, the elastic tubular body exerts an elastic restoring force to radially inwardly press the grasp part which thereby grasps the optical fiber.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: January 25, 2000
    Assignees: Sumitomo Electric Industries, Ltd., Koken Co., Ltd.
    Inventors: Kazuki Sogabe, Hideya Konda, Toshihiro Nakae, Mitsuyoshi Suzuki