Abstract: In the present invention, among blood metabolites, amino acids, organic compounds and oxylipins that were statistically significantly differentiated from the control group, were selected from type 2 diabetes patients. Specifically, asparagine, aspartic acid, glutamic acid, cysteine, lysine, citric acid, and uric acid, and 12-oxo ETE, 15-oxo ETE, 9-oxo ODE, and 20-carboxy leukotriene B4, which are oxylipins, were confirmed to have cutoff values of AUC>0.7. In addition, the blood metabolites showed a significant difference between a DME patient group and a non-DME patient group, and thus were confirmed to be usable for accurate diagnosis of DME.

Abstract: In a method for producing acetoin, butanediol, or butanol from ethanol according to the present invention, a cell-free catalysis method was used by designing an artificial synthetic pathway so that proteins of NOX, EtDH, FLS, BDH, and DDH and variant proteins thereof exhibit cascade catalytic activity as enzymes. Compared to existing fermentation methods using microorganisms, the production method according to the present invention does not require cell growth and has a short synthetic pathway, a fast reaction rate, high yield and productivity, adjustment of targeted reaction conditions is convenient, and butanol may be effectively produced. Moreover, same may be reused numerous times by fixing the proteins to nano-particles, and are also effective for producing acetoin, butanediol, or butanol, thus being economical. Therefore, the production method may be usefully adopted in the relevant industries requiring acetoin, butanediol, or butanol.

Abstract: In a method for producing acetoin, butanediol, or butanol from ethanol according to the present invention, a cell-free catalysis method was used by designing an artificial synthetic pathway so that proteins of NOX, EtDH, FLS, BDH, and DDH and variant proteins thereof exhibit cascade catalytic activity as enzymes. Compared to existing fermentation methods using microorganisms, the production method according to the present invention does not require cell growth and has a short synthetic pathway, a fast reaction rate, high yield and productivity, adjustment of targeted reaction conditions is convenient, and butanol may be effectively produced. Moreover, same may be reused numerous times by fixing the proteins to nano-particles, and are also effective for producing acetoin, butanediol, or butanol, thus being economical. Therefore, the production method may be usefully adopted in the relevant industries requiring acetoin, butanediol, or butanol.

Abstract: The present disclosure relates to a composition for promoting immune activity including a protein selected from the group consisting of dimeric proinsulin, C-peptide partially deleted mutant of dimeric proinsulin, and C-peptide partially deleted mutant of monomeric proinsulin as an effective component and a composition for immunosuppression including C-peptide site of proinsulin as an effective component, and the dimeric proinsulin, the C-peptide partially deleted mutant of dimeric proinsulin, and the C-peptide partially deleted mutant of monomeric proinsulin can be applied as immune enhancers to diabetic patients.

Abstract: The present invention relates to a fiber-optic sensor system for measuring the relative dose of a therapeutic proton beam by measuring Cerenkov radiation and a method of measuring using the same, and more particularly to a fiber-optic sensor system for precisely and economically measuring a proton beam by measuring the Cerenkov radiation generated from a fiber-optic sensor and a method of measuring using the same. The present invention comprises a proton beam source, a fiber-optic sensor for measuring the Bragg peak of the proton beam and SOBP, an optical detector for measuring the Cerenkov radiation, and a pair of optical fibers connecting the fiber-optic sensor and the optical detector, wherein the fiber-optic sensor being irradiated with a proton beam, the Cerenkov radiation generated in the optical fibers themselves is delivered through the optical detector to an amplifier system, and the resulting signal is transferred to a computer.

Abstract: There is provided a novel self-inflating bag with specific compression marks for pediatric and adolescent resuscitation. The self-inflating bag provides various different range of accurate tidal volume depending on different size or weight of patient by marking compression points on the self-inflating bag.

Abstract: Disclosed herein is a sample collection apparatus which includes a pretreatment unit arranged in front of a sample collection section to remove moisture, a first Peltier trap positioned at the lower side of the pretreatment unit to perform cooling condensation and thermal desorption, a switching valve connected to the rear of the pretreatment unit to determine flow paths through first, second, third and fourth ports, a sample collection section arranged at the rear of the switching valve to collect samples, a second Peltier trap positioned at the lower side of the sample collection section to perform thermal desorption, a first air pump connected to the second port of the switching valve to intake air, a second air pump connected to the rear of the sample collection section to intake and exhaust air, and a sample analyzer connected to the fourth port of the switching valve to analyze the samples.